Uric Acid and Coronary Artery Disease, Two Sides of a Single Coin: A Determinant of Antioxidant System or a Factor in Metabolic Syndrome

Why Serum Uric Acid is Important for the Development of Atherogenic Vascular Disease?

“…Role of serum uric acid in the development of cardiovascular diseases has been debated. 1,3 Increased prevalence of hyperuricemia was reported in disorders like HT, DM, dyslipidemia, and obesity. All of these comorbidites may contribute to the development of CVDs including CAD and CeVD independent from serum uric acid level.…”

“…All of these comorbidites may contribute to the development of CVDs including CAD and CeVD independent from serum uric acid level. 3,11,12 Thus, association of hyperuricemia and CVDs may be confounded by these disorders. 3 However, elevation of serum uric acid prior to the development of HT or metabolic syndrome was reported in the literature.…”

“…Although it has been known as an antioxidant agent in plasma, association of hyperuricemia and diseases with increased oxidative stress such as obesity, HT, metabolic syndrome and coronary arter disease (CAD) were reported. [2][3][4] The underlying mechanism causing this paradox is not clear. It was hypothesed that increase in serum uric acid level might be a defense mechanism.…”

Relationship Between Metabolic Syndrome and Serum Uric Acid in an Iranian Community Elderly Population: A Cohort Aging Study

“…15 However, the relationship between serum UA levels and the MetS remains controversial. 16,17 In Iran, several studies have been conducted to examine this relationship, [18][19][20][21] but they have often different methodology through subjects or study designs. Some studies took a wide range of people for age with different health status, 18 some only in adolescents, 19 some in patients with coronary artery disease or diabetes, 20,21 and some just in the middle-aged healthy population.…”

“…16,17 In Iran, several studies have been conducted to examine this relationship, [18][19][20][21] but they have often different methodology through subjects or study designs. Some studies took a wide range of people for age with different health status, 18 some only in adolescents, 19 some in patients with coronary artery disease or diabetes, 20,21 and some just in the middle-aged healthy population. 22 Although, some studies have shown that UA or HUA is associated with MetS or some of its components, a large population-based study in elderly people may have different results.…”