Uric Acid—An Emergent Risk Marker for Thrombosis?

Țăpoi, Laura; Șalaru, Delia Lidia; Sascău, Radu Andy; Stătescu, Cristian

doi:10.3390/jcm10102062

Cited by 17 publications

(15 citation statements)

References 51 publications

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“…UA can cause vascular damage through a variety of mechanisms, and elevated UA levels are associated with endothelial dysfunction, inflammation, and a prothrombotic state. Therefore, UA can be used as a biomarker for the prothrombotic state [ 28 ]. Proximal pulmonary artery dilatation was observed on echocardiography PE, suggesting possible pulmonary hypertension or high right ventricular overload.…”

Section: Discussionmentioning

confidence: 99%

A new nomogram prediction model for pulmonary embolism in older hospitalized patients

Liu,

Xiao,

Liu

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A new nomogram prediction model for pulmonary embolism in older hospitalized patients

Liu,

Xiao,

Liu

et al. 2024

Heliyon

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“…However, the association between serum uric acid levels and cardiovascular diseases (CVD) may not be J-shaped. Previous studies have reported that an approximate U-shaped association between serum uric acid levels and 10-year CVD risk scores exists in men, while a J-shaped association existed in women [ 24 ]. Uric acid levels were obviously higher in young patients with STEMI in this study than in older patients, although the value did not exceed the upper limit.…”

Section: Discussionmentioning

confidence: 99%

Clinical risk factors and outcomes of young patients with acute ST segment elevation myocardial infarction: a retrospective study

Liang

Pang

Gao

et al. 2023

BMC Cardiovasc Disord

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Background This study aimed to analysis the clinical characteristics and prognosis of acute STEMI in patients aged ≤ 45 years. Methods Seven hundred and one patients with STEMI from Liaocheng People’s Hospital from January 2018 to March 2021 were included in this study. Clinical characteristics, management, and outcomes (average follow-up: 11.5 months) were compared between patients aged ≤ 45 years and those aged > 45 years. Results Of the patients with STEMI who underwent primary percutaneous coronary intervention, 108 (15.4%) were aged ≤ 45 years. Compared to the older group, the younger patient group included more males, current smokers, and those with alcohol use disorder (AUD) or a family history of ischaemic heart disease (IHD). The culprit vessel in young patients was the left anterior descending (LAD) artery (60% vs. 45.9%, P = 0.031), which may have been due to smoking (odds ratio, 3.5; 95% confidence interval: 1.12–10.98, P = 0.042). Additionally, young patients presented with higher low-density lipoprotein and lower high-density lipoprotein levels than older patients; uric acid levels were also significantly higher in younger patients than that in the older group. Diabetes showed a trend toward major adverse cardiovascular events (MACE) in both groups; age and sex were both independent predictors of MACE in older patients. Conclusion More patients who were smokers, had AUD, or a family history of IHD were present in the young patient group. Hyperuricaemia (but not dyslipidaemia) was a prevalent risk factor in patients aged ≤ 45 years. Diabetes should be controlled to reduce cardiovascular events in young patients.

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“…Elevated serum UA level is associated with a wide range of diseases such as hypertension, chronic kidney disease, heart failure, and coronary artery disease, all these making it an important risk diagnostic tool [ 32 ]. Uric acid has been shown to be a useful biochemical marker of endothelial function, atherosclerosis, development of cardiovascular risk factors, and occurrence of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Role of Uric Acid to Creatinine Ratio for the Identification of Patients with Adverse Pulmonary Embolism Outcomes

et al. 2022

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Background: Uric acid (UA) is the final product of purine metabolism and a marker of oxidative stress that may be involved in the pathophysiology of cardiovascular and thromboembolic disease. The aim of the current study is to investigate the potential value of UA to creatinine ratio (UA/Cr) as a diagnostic tool for the outcome of patients admitted with acute pulmonary embolism (PE) and the correlations with other parameters. Methods: We evaluated 116 patients who were admitted for PE in a respiratory medicine department. PE was confirmed with computed tomography pulmonary angiography. Outcomes evaluated were hospitalization duration, mortality or thrombolysis and a composite endpoint (defined as mortality or thrombolysis). Patients were assessed for PE severity with the PE Severity Index (PESI) and the European Society of Cardiology (ESC) 2019 risk stratification. Results: The median (interquartile range) UA/Cr level was 7.59 (6.3–9.3). UA/Cr was significantly associated with PESI (p < 0.001), simplified PESI (p = 0.019), and ESC 2019 risk stratification (p < 0.001). The area under the curve (AUC) for prediction of 30-day mortality by UA/Cr was 0.793 (95% CI: 0.667–0.918). UA/Cr levels ≥7.64 showed 87% specificity and 94% negative predictive value for mortality. In multivariable analysis UA/Cr was an independent predictor of mortality (HR (95% CI): 1.620 (1.245–2.108), p < 0.001) and composite outcome (HR (95% CI): 1.521 (1.211–1.908), p < 0.001). Patients with elevated UA/Cr levels (≥7.64) had longer hospitalization (median (IQR) 7 (5–11) vs. 6 (5–8) days, p = 0.006)), higher mortality (27.3% vs. 3.2%, p = 0.001) and worse composite endpoint (32.7% vs. 3.4%, p < 0.001). Conclusion: Serum UA/Cr ratio levels at the time of PE diagnosis are associated with disease severity and risk stratification, and may be a useful biomarker for the identification of patients at risk of adverse outcomes.

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Uric Acid—An Emergent Risk Marker for Thrombosis?

Cited by 17 publications

References 51 publications

A new nomogram prediction model for pulmonary embolism in older hospitalized patients

A new nomogram prediction model for pulmonary embolism in older hospitalized patients

Clinical risk factors and outcomes of young patients with acute ST segment elevation myocardial infarction: a retrospective study

The Diagnostic Role of Uric Acid to Creatinine Ratio for the Identification of Patients with Adverse Pulmonary Embolism Outcomes

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