Uric acid administration for neuroprotection in patients with acute brain ischemia

Chamorro, Ángel; Planas, Anna M.; Muner, Dolors Soy; Deulofeu, Racoon

doi:10.1016/s0306-9877(03)00324-4

Cited by 44 publications

(28 citation statements)

References 19 publications

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“…19 However, the definitive proof of causality between increased UA levels and better stroke outcome requires an appropriately designed therapeutic controlled trial. 24 For this reason, the Spanish Drugs Agency has recently approved a multicenter clinical trial of UA administration in patients with acute stroke treated with alteplase and which is due to start in 2010 (EudraCT 2007-002687-95 and NCT00860366). …”

Section: Discussionmentioning

confidence: 99%

Uric Acid Levels Are Relevant in Patients With Stroke Treated With Thrombolysis

Amaro

Urra

Gómez-Choco

et al. 2011

Stroke

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107

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Background and Purpose-Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke. Methods-A total of 317 consecutive patients treated with thrombolysis were included in a prospective stroke registry.Demographics, laboratory data, neurological course, and infarction volume were prospectively collected. Excellent outcome was defined as achieving a modified Rankin Scale score Ͻ2 at 90 days. Binary and ordinal logistic regression models were used to analyze modified Rankin Scale score at 90 days. Results-UA levels were significantly higher in patients with an excellent outcome than in patients with a poor outcome (5.

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Section: Discussionmentioning

confidence: 99%

Uric Acid Levels Are Relevant in Patients With Stroke Treated With Thrombolysis

Amaro

Urra

Gómez-Choco

et al. 2011

Stroke

Self Cite

107

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“…Although adenine nucleotide concentrations and energy charge were not modified in our study, uric acid levels were increased in the IPC group. Although uric acid, a metabolite of the adenine nucleotide pathway, was previously thought to have a negative effect on I/R injury, it has recently been shown to have a beneficial effect as a very active scavenger (36,37). The high uric acid levels in the IPC group in our study suggest a better cell environment to eliminate toxic substances such as hypoxanthine and xanthine during reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Ischemic Pre-conditioning in Deceased Donor Liver Transplantation: A Prospective Randomized Clinical Trial

Amador

Grande

Marti³

et al. 2007

American Journal of Transplantation

104

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To assess the immediate and long-term effects of ischemic preconditioning (IPC) in deceased donor. liver transplantation (LT), we designed a prospective, randomized controlled trial involving 60 donors: control group (CTL, n = 30) or study group (IPC, n = 30). IPC was induced by 10-min hiliar clamping immediately before recovery of organs. Clinical data and blood and liver samples were obtained in the donor and in the recipient for measurements. IPC significantly improved biochemical markers of liver cell function such as uric acid, hyaluronic acid and Hypoxia-Induced Factor-1alpha (HIF-1a ) levels. Moreover, the degree of apoptosis was significantly lower in the IPC group. On clinical basis, IPC significantly improved the serum aspartate aminotransferase (AST) levels and reduced the need for reoperation in the postoperative period. Moreover, the incidence of primary nonfunction (PNF) was lower in the IPC group, but did not achieve statistical significance. We conclude that 10-min IPC protects against I/R injury in deceased donor LT.

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“…Interestingly, while other studies failed to confirm the independent, negative prospective relationship between UA and cardiovascular morbidity and mortality (Forman et al 2007;Coutinho et al 2007;Hozawa et al 2006;Wheeler et al 2005;Hu et al 2001;Moriarity et al 2000;Culleton et al 1999), evidence that UA is a protective factor or a marker of good health status is limited to few studies on acute cerebral ischemia (Chamorro et al 2004) and the protective effect of UA on oxidative stress generated during physical activity (Waring et al 2003). Several mechanisms may explain the hypothetical negative effect of uric acid on health, including a direct stimulating effect of soluble non-crystalline UA on inflammation, the impairment of endothelial function and the development of pro-oxidant properties in specific metabolic conditions (Maxwell and Bruinsma 2001;Alderman 2002;Hediger et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons

Macchi

Molino-Lova

Polcaro

et al. 2008

Mechanisms of Ageing and Development

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Background-Previous studies have shown that oxidative protein damage is independently associated with low grip strength and that dietary intake and circulating levels of anti-oxidant vitamins are positive predictors of muscle strength among older persons. Since uric acid (UA), has strong anti-oxidant properties, we tested the hypothesis that UA levels is cross-sectionally associated with muscle strength and protective against the decline of strength over the aging process.

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Uric acid administration for neuroprotection in patients with acute brain ischemia

Cited by 44 publications

References 19 publications

Uric Acid Levels Are Relevant in Patients With Stroke Treated With Thrombolysis

Uric Acid Levels Are Relevant in Patients With Stroke Treated With Thrombolysis

Ischemic Pre-conditioning in Deceased Donor Liver Transplantation: A Prospective Randomized Clinical Trial

Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons

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