Uric acid a better scavenger of free radicals than vitamin C in rheumatoid arthritis

Mahajan, Mridula; Kaur, Sukhraj; Rawal, Shruti; Kant, Ravi

doi:10.1007/s12291-009-0038-6

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…RA patients in our study showed statistically significant increased serum uric acid level when compared with healthy controls as given in Table 1. This finding is in accordance with the Mahajan et al 26 The increased level of uric acid shows that it contributes to scavenging the free radicals. 27 Increased uric acid level in RA patients may be a compensatory response to combats the low levels of major non-enzymatic antioxidants like vitamin C and E.…”

Section: Discussionsupporting

confidence: 92%

Status of oxidants and antioxidants in rheumatoid arthritis patients of north Karnataka

2016

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Background: Oxidant stress as a result of increased production of reactive oxygen species (ROS) or a reduction in the body’s endogenous antioxidant defense system is a hallmark of chronic inflammatory diseases including rheumatoid arthritis (RA). The objective of the study was to establish the status of oxidative/nitrosative stress in RA patients of north Karnataka.Methods: Thirty RA patients and equal number of healthy individuals (controls) were included in the study. The morning stiffness (MS) and disease activity score 28 (DAS28) of RA patients were examined. Erythrocyte sedimentation rate (ESR) and hemoglobin (Hb) levels were estimated. Biochemical parameters uric acid, lipid peroxide (LPO), nitric oxide (NOx), vitamin C & E, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured.Results: Significant increased ESR (11.20 mm/hr vs. 40.97 mm/hr, 265.80%), uric acid (3.85 mg/dL vs. 6.73 mg/dL, 74.81%), LPO (1.12 μmol/L vs. 2.35 μmol/L, 109.82%) and NOx (16.19 μmol/L vs. 45.43 μmol/L, 180.61%) levels with significant decreased of the levels of Hb (12.59 g/dL vs. 10.16 g/dL, 19.30%), vitamin C & E (11.20.mg/L vs. 3.87.mg/dL, 65.45% and 13.01 mg/L vs. 7.05 mg/dL, 45.81%), SOD (3757.90 U/g Hb vs. 2201.20 U/g Hb, 41.42%) and GSH-Px (1.81 U/g Hb vs. 0.92 U/g Hb, 49.17%) were observed in RA. There was direct correlation found between MS, DAS-28 and ESR with serum LPO and NOx in RA patients. A significant negative correlation was detected between activity parameters with biochemical parameters in RA patients.Conclusions: Increased oxidants level and decreased non-enzymatic/enzymatic antioxidants level in RA patients of north Karnataka confirm an association between oxidative/nitrosative stress and rheumatoid arthritis.

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Section: Discussionsupporting

confidence: 92%

Status of oxidants and antioxidants in rheumatoid arthritis patients of north Karnataka

2016

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“…The same result was reported by [18]. This increase in uric acid level which may refer to the physiological activity and the influence of destroyed or catabolism [19].Increased level of uric acid may contribute much more to scavenging of free radicals. This may support the powerful antioxidant role of uric acid in scavenging singlet oxygen and other free radicals [20] and [21].…”

Section: Discussionsupporting

confidence: 81%

Renal function tests in patients with Cutaneous Leishmania after treatment with Glucantime

Hasani¹,

Kotayni²,

kabba³

2020

IJEAS

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Cutaneous leishmaniasis (CL) has historically been present in Syria, mainly in the western part of the country. The present study was conducted to evaluate kidney function parameters in patients infected with CL in Idlep-Syria. This is controlled study contain infected (60) and control (30) groups. The prevalence and distribution of infection were studied, kidney function testes were determined by colorimetric methods, (Biosystem ®). Among 100 of a total cases studied, the percent of infected cases are 60 % and not infected are 40%. The distribution of lesions on various parts of body in patients shows the highest percent of infection was in face (50%). There were highly significant increase in urea, uric acid and creatinine in infected group (p <0.0001) as compared to control one. In the war in Syria, the prevalence of infection was increased and had side effect on kidney parameter in infected patients treated with Glucantime.

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“…As urate was previously reported to act as a pro-oxidant under some conditions [13] , we also studied the effect of urate on oxidative stress by determining the protein oxidation product carbonyl levels. We found that 50 µmol/l 6-OHDA treatment enhanced the cellular protein carbonyl levels, which was obviously attenuated in the presence of 200 µmol/l urate pretreatment.…”

Section: Resultsmentioning

confidence: 99%

Nrf2 Signaling Contributes to the Neuroprotective Effects of Urate against 6-OHDA Toxicity

et al. 2014

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BackgroundMounting evidence shows that urate may become a biomarker of Parkinson's disease (PD) diagnosis and prognosis and a neuroprotectant candidate for PD therapy. However, the cellular and molecular mechanisms underlying its neuroprotective actions remain poorly understood.ResultsIn this study, we showed that urate pretreatment protected dopaminergic cell line (SH-SY5Y and MES23.5) against 6-hydroxydopamine (6-OHDA)- and hydrogen peroxide- induced cell damage. Urate was found to be accumulated into SH-SY5Y cells after 30 min treatment. Moreover, urate induced NF-E2-related factor 2 (Nrf2) accumulation by inhibiting its ubiquitinationa and degradation, and also promoted its nuclear translocation; however, it did not modulate Nrf2 mRNA level or Kelch-like ECH-associated protein 1 (Keap1) expression. In addition, urate markedly up-regulated the transcription and protein expression of γ-glutamate-cysteine ligase catalytic subunit (γ-GCLC) and heme oxygenase-1 (HO-1), both of which are controlled by Nrf2 activity. Furthermore, Nrf2 knockdown by siRNA abolished the intracellular glutathione augmentation and the protection exerted by urate pretreatment.ConclusionOur findings demonstrated that urate treatment may result in Nrf2-targeted anti-oxidant genes transcription and expression by reducing Nrf2 ubiquitination and degradation and promoting its nuclear translocation, and thus offer neuroprotection on dopaminergic cells against oxidative stresses.

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Uric acid a better scavenger of free radicals than vitamin C in rheumatoid arthritis

Abstract: Uric acid an endogenous aqueous antioxidant in normal humans is present in much higher

Cited by 15 publications

References 7 publications

Status of oxidants and antioxidants in rheumatoid arthritis patients of north Karnataka

Status of oxidants and antioxidants in rheumatoid arthritis patients of north Karnataka

Renal function tests in patients with Cutaneous Leishmania after treatment with Glucantime

Nrf2 Signaling Contributes to the Neuroprotective Effects of Urate against 6-OHDA Toxicity

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