Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach

Kuebler, Wolfgang M.; Jordt, Sven‐Eric; Liedtke, Wolfgang

doi:10.1152/ajplung.00161.2020

Cited by 56 publications

(45 citation statements)

References 50 publications

(63 reference statements)

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“…Therefore, patients with low serum calcium might have impaired hemostatic mechanisms. And one study suggested that the occurrence of pulmonary edema in COVID-19 patients may be related to the radio-permeable TRPV4 channel, and the pulmonary edema caused by the virus can be alleviated by TRPV4 inhibitors (31). In one case-cohort research, serum Ca was proofed to be inversely In conclusion, low calcium is not only the electrolyte imbalance caused by viral infection, but also one of the key factors causing multi-organ injury, and it may help to judge the severity of disease in the early stage of virus.…”

Section: Discussionmentioning

confidence: 99%

Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical

et al. 2020

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Background: Coronavirus disease 2019 (COVID-19) virus is still spreading, finding out the initial hits of viral infection is important to minimize the mild/moderate population, prevent disease aggravation and organs dysfunction. Objective: We investigated COVID-19 patients with different serum calcium levels. Design: We checked the serum calcium level of the patients based on days after symptom onset as well as the severity of COVID-19. We also checkeed multi-organ injuries and immune cytokines level in their blood. Results: Both mild/moderate and severe critical cases we observed showed low calcium level in the early stage of viral infection, while the severe/critical cases showed significant lower calcium level than mild/moderate cases in the early stage. We also found that low calcium level related to severe/critical multi-organ injuries especially in the mild/moderate population. Proinflammatory cytokine IL-6 also correlated to calcium change in both mild/moderate and severe/critical cases. Conclusions: Our finding indicates that calcium balance is a primal hit of COVID-19 and a biomarker of clinical severity at the beginning of symptom onset. Calcium is closely associated with virus-associated multiple organ injuryes and the increase of inflammatory cytokines. Our results provide a new, important indicator of COVID-19 patients from mild/moderate to severe/critical: serum calcium.

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Section: Discussionmentioning

confidence: 99%

Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical

et al. 2020

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“…Control of pulmonary edema is crucial in limiting the severity of ARDS ( 58 ). In this light, TRPV4 channels in the alveolo-capillary unit were recently proposed to be a pharmacologically tractable target for treatment of ARDS associated with COVID-19 ( 30 ). In addition to direct control of lung barrier function by TRPV4 inhibitors, there is evidence that TRPV4 channels could induce PANX1 channel activity ( 45 , 49 , 50 ), suggesting that PANX1 inhibitors might improve the efficacy of TRPV4 channel inhibitors.…”

Section: Regulation Of Inflammation By Panx1 In the Context Of Covid-mentioning

confidence: 99%

Consideration of Pannexin 1 channels in COVID-19 pathology and treatment

Swayne

Johnstone

et al. 2020

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Although TRP channels have no role in healthy lung function, repair processes use them to promote endothelial permeability, inducing inflammation for immune action, which are normal helper processes. Still, again their activation could become pathological [326], involved in asthma, COPD, and pulmonary fibrosis [327] and pulmonary edema [328].…”

Section: The Hypothesismentioning

confidence: 99%

A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19

Szász¹

2021

OJBIPHY

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Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach

Abstract: Kuebler WM, Jordt SE, Liedtke WB. Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.

Cited by 56 publications

References 50 publications

Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical

Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical

Consideration of Pannexin 1 channels in COVID-19 pathology and treatment

A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19

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