Urgency and pain in patients with overactive bladder and bladder pain syndrome. What are the differences?

Castro-Díaz, David; Cardozo, Linda; Chapple, Christopher R.; Espuña, Montserrat; Kelleher, Con; Kirby, Michael; Milsom, Ian; Sievert, K.D.; Tubaro, Andrea

doi:10.1111/ijcp.12317

Cited by 17 publications

(10 citation statements)

References 62 publications

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“…Although urinary symptoms may be typical for acute cystitis, they are, however, not specific because they are also found in patients with other urological disorders. [20,21]. Therefore, not only their presence but also their severity need to be considered.…”

Section: Main Findingsmentioning

confidence: 99%

Acute Cystitis Symptom Score (ACSS): Clinical Validation of the Italian Version

et al. 2020

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Acute Cystitis Symptom Score (ACSS) is an 18-item self-reporting questionnaire for clinical diagnosis and follow-up of acute uncomplicated cystitis (AUC) in women. The ACSS, originally developed in Uzbek and Russian languages, is now available in several languages. The purpose of the study was to validate the ACSS questionnaire in the Italian language. Linguistic validation was carried out according to Linguistic Validation Manual for Patient-Reported Outcomes Instruments guidelines. Clinical validation was carried out by enrolling one hundred Italian-speaking women. All women were asked to fill in the ACSS questionnaire during their medical visit. Fifty-four women, median age 36 (Inter Quartile Range 28–49), were diagnosed with AUC, while 46 women, median age 38 (IQR 29–45), were enrolled as the control group attending the hospital’s fertility center for couples. The most frequently isolated pathogen in AUC was Escherichia coli (40; 74.0%) followed by Enterococcus faecalis (7; 13.0%) and Staphylococcus saprophyticus (3; 5.6%). Receiver operating characteristic (ROC) curve analysis performed at the first diagnostic visit on a typical symptoms domain cut-off score of 6 revealed a sensitivity of 92.5% and specificity of 97.8%. The Italian version of the ACSS has proved to be a reliable tool with a high accuracy in diagnosis and follow-up in women with AUC. The ACSS may also be useful for clinical and epidemiological studies.

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Section: Main Findingsmentioning

confidence: 99%

Acute Cystitis Symptom Score (ACSS): Clinical Validation of the Italian Version

et al. 2020

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“…Similarly, J. Quentin Clemens 7 classifies OAB and IC/BPS primarily as genitourinary sensory disorders with an underlying dysfunction of the afferent nervous system, referring to them as afferent urological and/or pelvic disorders 7 . Others disagree and maintain that IC/BPS and OAB are separate conditions, distinguished primarily by the presence of pain with bladder filling in patients with IC/BPS and the generally episodic nature of urinary urgency (relatively fast onset and/or disappearance) in patients with OAB compared with the progressive build-up of bladder pain and discomfort with bladder filling in paatients with IC/BPS 133,134 , while acknowledging that the two conditions can also occur in the same patient. Diagnostic criteria and clinical definitions of IC/BPS have undergone considerable revisions in the past decade, but the ongoing lack of agreement or uniformity in how these conditions are defined certainly adds to the confusion in understanding the underlying contributory mechanisms.…”

Section: A Common Role For Central Sensitizationmentioning

confidence: 99%

Does central sensitization help explain idiopathic overactive bladder?

et al. 2016

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The pathophysiological mechanisms underlying overactive bladder syndrome (OAB) can include dysfunction of sensory pathways of the peripheral and central nervous systems, resulting in bladder hypersensitivity. Central sensitization describes an induced state of spinal hypersensitivity that is associated with a variety of chronic pain disorders that share many attributes with OAB, albeit without the presence of pain. As such, the concept of central sensitization might be relevant to understanding the mechanisms and clinical manifestations of OAB syndrome. An understanding of the pathophysiology and clinical manifestations of central sensitization, and the evidence that supports a role of central sensitization in OAB, including the potential implications of mechanisms of central sensitization for the treatment of patients with OAB could provide a novel approach to the treatment of patients with this disease. Such an approach would be especially relevant to those patients with central sensitization-related comorbidities, and has the potential to improve the outcomes of these patients in particular.

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“…These chronic bladder diseases are defined by subjective and often overlapping clinical symptoms. 1 The hallmark symptom of OAB is urgency while BPS/IC is defined by the key symptom pain 1 accompanied by at least 1 other symptom, such as a persistent urge to void or urinary frequency. 2 Only patients with BPS/IC who have Hunner lesions can be diagnosed by cystoscopy alone.…”

mentioning

confidence: 99%