Urethral prolapse after durasphere injection

Ghoniem, Gamal M.; Khater, Usama

doi:10.1007/s00192-005-1336-z

Cited by 32 publications

(16 citation statements)

References 5 publications

(6 reference statements)

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“…We have performed more than 80 cases of CaHA injections before this complication was encountered. There is only one report each in the literature of urethral prolapse formation after collagen injection [3], carbon-coated beads injection [4], or CaHA injection [5]. We do not believe that this complication is specific for CaHA, since formation of urethral prolapse has been described with other injectable materials.…”

Section: Discussionmentioning

confidence: 99%

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Large urethral prolapse formation after calcium hydroxylapatite (Coaptite) injection

2008

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A 67-year-old woman who had failed two prior anti-incontinence surgeries presented with stress urinary incontinence and intrinsic sphincteric deficiency. Calcium hydroxylapatite (Coaptite(R)) was injected cystoscopically into the bladder neck and proximal urethra and resolved her incontinence. Seven months later, she presented with difficulty in voiding and a urethral mass. Physical examination revealed a large prolapse of the urethral mucosa obstructing the external urethral meatus. Surgical exploration revealed local migration of calcium hydroxylapatite particles from the site of injection (bladder neck and proximal urethra) to the distal urethra. The prolapsed urethral mucosa was incised and marsupialized. Improper injection techniques likely contributed to urethral prolapse in this complication. Meticulous attention to injection techniques is the key to treatment success of urethral bulking agents, particularly in patients who have a scarred/fixed urethra or have multiple urethral/vaginal surgeries.

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Section: Discussionmentioning

confidence: 99%

“…Collectively, these experiences suggest that the incidence of local CaHA migration is probably low. Nevertheless, submucosal migration of the bulking agent has been reported in isolated cases [3][4][5]9].…”

Section: Discussionmentioning

confidence: 99%

Large urethral prolapse formation after calcium hydroxylapatite (Coaptite) injection

2008

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“…Three reports exist, each describing a different agent: collagen, calcium hydroxylapatite (CaHA), and Durasphere (Boston Scientifi c, Natick, MA) [20][21][22]. In all three cases, successful treatment was achieved with surgical excision of the prolapsed mucosa.…”

Section: Urethral Prolapsementioning

confidence: 95%

Benign masses of the female periurethral tissues and anterior vaginal wall

Fletcher¹,

Lemack

2008

Curr Urol Rep

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Due to their rarity, benign masses of the periurethral tissues and anterior vaginal wall are poorly understood. Arriving at the proper evaluation and treatment is challenging because many of these masses have similar presenting signs and symptoms, as well as overlapping differential diagnoses. The literature regarding these lesions mainly consists of level III evidence, mostly involving case reports and series. Clinical management has traditionally been based on established surgical principles and expert opinion. This review presents the pertinent embryologic and anatomic background for these benign masses, as well as other pertinent etiological processes. Furthermore, the most current evidence is reviewed regarding the differential diagnosis, evaluation, and treatment for each mass.

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“…Injected around the bladder neck of pigs, no inflammatory response, no foreign body reaction, or migration was detected of the glass beads. However, this little macrophage activity and only tender encapsulation with soft tissue (Figure 4) was the obvious reason for dislocation according gravity in form of a prolapsed [62].…”

Section: Figure 11mentioning

confidence: 99%

Biocompatibility of Injectable Microspheres

Lemperle¹

2018

BJSTR

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Urethral prolapse after durasphere injection

Cited by 32 publications

References 5 publications

Large urethral prolapse formation after calcium hydroxylapatite (Coaptite) injection

Large urethral prolapse formation after calcium hydroxylapatite (Coaptite) injection

Benign masses of the female periurethral tissues and anterior vaginal wall

Biocompatibility of Injectable Microspheres

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