Urethral pressure profile before radical prostatectomy as a predictor of early postoperative continence

Abstract

Objective: Urinary incontinence (UI) is one of the most common complications of radical prostatectomy (RP). Impaired urethral sphincter function is generally considered to be the most important contributing factor for UI; however, the mechanism of onset and recovery of urinary continence has not been fully elucidated. The objective of this research was to evaluate preoperative functional urethral length (FUL) and maximum urethral closure pressure (MUCP) as early continence recovery predictors after open retropubic RP (ORRP).Methods: The research was conducted on a group of 43 patients with localized prostate cancer (PCa) in the period from July 2019 to May 2021. The urodynamic method of urethral pressure profile (UPP) was used to assess FUL and MUCP, and correlate with the postprostatectomy continence recovery. The severity of UI and bothersome were assessed using fully validated International Consultation on Incontinence Questionnaire – Urinary Incontinence Short Form (ICIQ‐UI SF) and number of pads used in 24 h. Patients were interviewed about the use of urinary pads and asked to fill out the ICIQ‐UI SF before and 2, 8, 16 and 24 weeks after ORRP.Results: The median value of FUL (mm) and MUCP (cmH2O) was 69 (28–94) and 76 (16–223), respectively. Correlation and linear regression showed a statistically significant negative correlation between preoperative values of FUL and MUCP with ICIQ symptom score and the number of pads used per day at the four observed time intervals (p < 0.05). Such a result showed that patients with higher preoperative FUL and MUCP values were more likely to recover urinary continence earlier. A value of 65 mm for FUL and 80 cmH2O for MUCP proved to be the cut‐off values for continence recovery in 24 weeks after ORRP.Conclusion: Preoperatively evaluated FUL and MUCP seem to be valuable prognostic factors for early continence recovery after ORRP. Further investigation on a larger patient cohort is needed to evaluate the role of UPP in the preoperative management of patients with PCa.

Functional Magnetic Stimulation of the Pelvis and Urinary Incontinence after Radical Prostatectomy

“…In order to properly assess it, different methods can be used from magnetic resonance imaging to obtain anatomical data and urodynamic studies to add functional information's regarding pressure values before and/or after the surgery. (14,15) However, these methods can add additional costs, time and burden for the patients and therefore are not used often. With the introduction of minimally invasive procedures, we have new methods which can be used to assess preserved part of the urethra by using semi-quantitatively measured on a video screen which have confirmed that patients with longer preserved urethral length have a significantly higher rate of post-operative urinary continence recovery.…”