Urethral and Bladder Current Perception Thresholds: Normative Data in Women

Kenton, Kimberly; Simmons, Jennifer; FitzGerald, Mary P.; Löwenstein, Lior; Brubaker, Linda

doi:10.1016/j.juro.2007.03.032

Cited by 31 publications

(39 citation statements)

References 21 publications

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“…Urethral CPT values have been reported to be lower in older women with overactive bladder, suggesting that aging and possibly overactive bladder are associated with loss of urethral afferent nerve function [45]. This is consistent with histologic investigations that have demonstrated a decline in the number and density of striated urethral sphincter nerve and muscle fi bers with age [46,47].…”

Section: Clinical Applicability Of Electrical Cpt Testingsupporting

confidence: 79%

Bladder sensation testing: Where are we?

Daneshgari

Kenton²

2009

Curr Bladder Dysfunct Rep

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Section: Clinical Applicability Of Electrical Cpt Testingsupporting

confidence: 79%

Bladder sensation testing: Where are we?

Daneshgari

Kenton²

2009

Curr Bladder Dysfunct Rep

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“…The neuroselectivities of the 5, 250, and 2,000 Hz frequencies of Neurometer ® stimuli for C, Aδ, and Aβ fibers, respectively, have been established at cutaneous sites in humans 6 and rats 5,7 . Interestingly, the feasibility of fiber-type-selective assessment of bladder sensory thresholds was first reported in the clinical setting using a transurethral electrode in conjunction with the Neurometer ® 15–17 . Those reports indicated the potential utility of the Neurometer® in assessing quantitative hypersensitivities of Aδ or C fibers, which are involved in common bladder pathologies.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Neuroselective and Site-specific Nociceptive Stimuli of Rat Bladder

Yamada

Ukimura

Liu

et al. 2012

Urology

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Objectives To evaluate the organ specificity of sine-wave electrical stimulation of the bladder through assessment of expression of Fos-immunoreactive (IR) cells in rat spinal cord regions. Methods Thirty-seven female Sprague-Dawley rats were divided into eight groups: sham stimulation; 5, 250, and 2,000 Hz stimulation with 1.5 mA or 2.0 mA intensity; and a group instilled with capsaicin in bladder. Using a recently developed bladder sensory threshold device, sine-wave electrical stimulation was applied for 90 min to rat bladder. Spinal cord was harvested after sacrifice. Fos-IR cells in the spinal regions of the medial dorsal horn, lateral dorsal horn, dorsal commissure (DCM), and sacral parasympathetic nucleus (SPN) were measured. The distributions of Fos-IR neurons were compared. Results The maximum expression of Fos-IR cells, induced by 250-Hz and 5-Hz stimulation of the bladder, was found at L6 of the spinal cord and was significantly higher than in the control group (p < 0.01). Stimulation with 2,000 Hz did not induce any Fos-IR cells. Fos-IR neurons were predominantly seen in the SPN region in response to 250-Hz stimulation and in the DCM region in response to 5-Hz stimulation. The numbers of positive neurons were similar to the numbers caused by capsaicin instillation. Conclusions Frequency-specific sine-wave electrical stimulation of the rat bladder induced the expression of Fos-IR cells in a neuroselective manner. The bladder sensory threshold device could be used for exploration of the pathophysiology of the diseases with disturbances of afferent pathway of the bladder.

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“…In our study a homogeneous population of young females (20-28 years) without previous pregnancy was investigated. Age however has a considerable influence on LUT sensibility, which decreases with age (Kenton et al, 2007a;Kenton et al, 2007b;Kinn and Nilsson, 2005). Young women without previous childbirth have a more sensible urethra compared to elderly women or women with previous childbirth.…”

Section: Discussionmentioning

confidence: 99%

Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects—A placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release

Mehnert

Reitz

Youssef

et al. 2009

Neurourology and Urodynamics

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AimsThere is evidence that antimuscarinic drugs have depressant influence not only on bladder muscle activity, but also on bladder sensations. The aim of this study was to evaluate the effect of a single dose tolterodine extended release (ER) 4 and 8 mg on bladder sensations during filling cystometry.MethodsAfter approval of the local ethics committee, 30 healthy female subjects (23.7 ± 2.3 years) were included and randomly assigned to three groups: (A) placebo, (B) tolterodine ER 4 mg, and (C) tolterodine ER 8 mg in a double blind manner. Measurements were performed at baseline and 4 hr postmedication in each group, consisting of: (1) Filling cystometry with 25 ml/min at which subjects had to indicate first sensation of filling (FSF), first desire to void (FDV), and strong desire to void (SDV). (2) Uroflowmetry and ultrasound control for residual urine.ResultsIn the placebo group, filling volumes at FDV and SDV decreased significantly posttreatment. This effect could not be observed for the tolterodine 8 mg group and only at SDV in the 4 mg group. No significant difference between groups was found regarding uroflowmetry parameters and postvoid residual volume.ConclusionsNo increase of filling volumes in healthy subjects could be observed with tolterodine. However, the results suggest that tolterodine is able to alleviate irritation caused by repeated catheterization and cystometry. There was no significant influence of tolterodine ER 4 or 8 mg on voiding function. Neurourol. Urodynam. 29:464–469, 2010. © 2009 Wiley‐Liss, Inc.

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Urethral and Bladder Current Perception Thresholds: Normative Data in Women

Abstract: We report urethral and bladder current perception thresholds for a large sample of asymptomatic women. These reference values may help elucidate changes in afferent nerve function in women with lower urinary tract dysfunction.

Cited by 31 publications

References 21 publications

Bladder sensation testing: Where are we?

Bladder sensation testing: Where are we?

Efficacy of Neuroselective and Site-specific Nociceptive Stimuli of Rat Bladder

Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects—A placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release

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