Ureteral Strictures Following Radiotherapy: Incidence, Etiology and Treatment Guidelines

Goodman, Michael; Dalton, John R.

doi:10.1016/s0022-5347(17)52732-9

Cited by 22 publications

(4 citation statements)

References 7 publications

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“…Goodman M et al 8 in 1982 proved that the radiation given to the pelvic malignancies is a common cause of ureteric stricture. Wolf J S et al 9 in 1997 classified benign ureteric strictures into ischemic and non-ischemic strictures.…”

Section: Resultsmentioning

confidence: 99%

Ureteric Strictures an Analytical Study of Aetiology, Pathology and Management

R¹,

Priyadarsini²,

Vazhayil³

et al. 2017

jebmh

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BACKGROUND Ureteric strictures are common diseases of India due to tuberculosis, instrumentation, congenital and other reasons. In this study we found that tuberculosis (27%) and instrumentation (27%) were the leading causes of ureteric stricture. MATERIALS AND METHODS This is a prospective study conducted in the Department of Urology, Government Medical College, Thiruvananthapuram. Cases diagnosed as ureteric strictures by IVP and CT scan were taken up for this study. Their clinical features, investigations, treatment and surgical options were studied. RESULTS The total number of cases studied were 11 (5 males and 6 females). We found that three patients had tuberculous strictures and two patients had lower ureteric strictures with obstructive megaureter like presentation. Three cases had upper ureteric strictures with unknown aetiology. Three cases had iatrogenic ureteric strictures secondary to instrumentation. CONCLUSION We concluded from our study that Tuberculosis is a common cause of ureteric stricture. Prior history of instrumentation is the second most common cause of ureteric stricture. Lower ureteric stricture with obstructive megaureter like presentation was also not uncommon and an equally significant group of ureteric strictures had unknown aetiology.

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Section: Resultsmentioning

confidence: 99%

Ureteric Strictures an Analytical Study of Aetiology, Pathology and Management

R¹,

Priyadarsini²,

Vazhayil³

et al. 2017

jebmh

View full text Add to dashboard Cite

show abstract

“…Diagnosis is often late, and treatment is complicated ( 199 , 200 ). The overall incidence of stenosis is 0.4–2.7% ( 21 , 201 ). Strictures most often occur after radiotherapy for cervical cancer and are diagnosed in 3.3% of patients within 25 years after the end of cancer treatment ( 22 , 33 ).…”

Section: Ureteral Stricturementioning

confidence: 99%

Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review

Chorbińska¹,

Krajewski²,

Zdrojowy³

2021

Transl Cancer Res TCR

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Radiation therapy along with chemotherapy and surgery are the three main treatment modalities used in oncology. The main disadvantage of radiotherapy is the fact that it affects both cancer and healthy cells located in the tumour area. As a consequence, different complications develop. A large proportion of cancers treated with radiotherapy are located in the lower abdomen and pelvis, which is why complications often involve the urinary tract. Due to the anatomy of these areas, urological complications occur not only after radiological treatment of urological cancers, but also after treatment of malignancies of the reproductive or digestive system. The most common radiation-induced complications include haemorrhagic cystitis, urethral and ureteral strictures, urinary fistulae, and secondary primary malignancies. Adverse events significantly degrade the quality of life of the patient, and in severe cases can be life threatening to the patient. Because of impaired tissue healing, the treatment of radiation urological complications is a challenge for urologists and often requires complicated reconstruction techniques. Continuous increase in the effectiveness of cancer treatments and the extension of patients’ lives, make complications of radiation therapy an increasingly common clinical problem. The aim of this review is to present the pathophysiology, clinical presentation and methods of treatment for radiation-induced urological complications.

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“…Ureteric reconstructive surgery in patients who have undergone pelvic radiotherapy is difficult because of radiation damage to the bowel and the high complication rate of surgery on radiation‐damaged ureters [ 1, 2]. A transverse colonic conduit is usually recommended in patients with bilateral ureteric strictures after pelvic irradiation [ 3].…”

Section: Commentmentioning

confidence: 99%