Ureteral reconstruction with reinforced collagen scaffolds in a porcine model

Jonge, Paul de; Simaioforidis, Vasileios; Geutjes, Paul J.; Oosterwijk, Egbert; Feitz, W.F.J.

doi:10.1002/term.2366

Cited by 13 publications

(9 citation statements)

References 34 publications

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“…Due to their size, we previously used young pigs (3-6 months of age) for ureter reconstruction studies. 28 Their fast growth and rapid wound healing may have negatively impacted the remodeling of the neoureter and resulted in hydronephrosis; an undesired outcome. Adult goats have a similar size and weight to these young pigs, but have the wound healing capacity of adult animals.…”

Section: Discussionmentioning

confidence: 99%

Ureteral Reconstruction in Goats Using Tissue-Engineered Templates and Subcutaneous Preimplantation

K.J.D.

SloffMarije

JankeHeinz-Peter

et al. 2018

Tissue Engineering Part A

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Repair of long ureteral defects often requires long graft tissues and extensive surgery. This is associated with complications, including a lack of suitable tissue and graft site morbidity. Tissue engineering may provide an attractive alternative to the autologous graft tissues. In this study, ureteral repair using (preimplanted) tubular collagen-Vicryl templates was evaluated in a new goat model. Tubular templates were prepared from tubularized Vicryl meshes and 0.7% type-I collagen (length = 6 cm, inner diameter = 6 mm, wall thickness = 3 mm). In total, twelve goats were used and evaluated after 3 months. Eight goats were implanted with the collagen-Vicryl templates and in four goats the templates were first preimplanted in the subcutis and subsequently used as ureteral graft. Template implantation was successful in 92% of the goats(11/12). During follow-up, 82% of the animals (9/11) survived without signs of discomfort. Two animals were sacrificed prematurely due to kidney perforation by the stent and urine leakage. Two other animals presented with stenosis of the neoureter due to stent migration. After preimplantation, the templates were remodeled mostly to autologous tissue with similar mechanical characteristics as the native ureter. Goats grafted with preimplanted templates presented with predominantly healthy kidneys, whereas the goats grafted with the collagen-Vicryl templates presented with fibrotic and inflamed regions in the kidneys. The use of preimplanted tissue templates showed favorable results compared with direct functional implantation of the templates. Partial remodeling toward autologous tissue and similar mechanical characteristics likely improved the integration in the ureteral tissue. Preimplantation of tissue-engineered templates should therefore be considered when two-stage procedures using a nephrostomy catheter are indicated or when planning allows for additional time to treatment.

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Section: Discussionmentioning

confidence: 99%

Ureteral Reconstruction in Goats Using Tissue-Engineered Templates and Subcutaneous Preimplantation

K.J.D.

SloffMarije

JankeHeinz-Peter

et al. 2018

Tissue Engineering Part A

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“…While developing working prototypes, thorough testing in a simulated environment with computer models and high-fidelity physical manikins is highly recommended. After such technical validation, animal experiments in established animal models (12,14,(39)(40)(41)(42)(43) can confirm the feasibility to promote a clinical trial.…”

Section: Pls Technology Research and Developmentmentioning

confidence: 92%

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

et al. 2022

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Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-ethical and legal aspects, its application area, and the corresponding design implications. This paper represents the consensus opinion of a group of healthcare professionals, designers, ethicists, researchers and patient representatives, who have expertise in tertiary obstetric and neonatal care, bio-ethics, experimental perinatal animal models for physiologic research, biomedical modeling, monitoring, and design. The aim of this paper is to provide a framework for research and development of PLS technology. These requirements are considering the possible respective user perspectives, with the aim to co-create a PLS system that facilitates physiological growth and development for extremely preterm born infants.

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“…101 A reinforced collagen−Vicryl tubular scaffold is suitable for ureteral tissue engineering. 102 Another collagen−(polyurethane−urea) hy-drogel obtained outstanding elasticity. 103 However, further optimization to prevent strictures is required for both.…”

Section: Urological Reconstructionsmentioning

confidence: 99%

Collagen-Based Biomaterials for Tissue Engineering

Wang

Yan

2023

ACS Biomater. Sci. Eng.

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Collagen is commonly used as a regenerative biomaterial due to its excellent biocompatibility and wide distribution in tissues. Different kinds of hybridization or cross-links are favored to offer improvements to satisfy various needs of biomedical applications. Previous reviews have been made to introduce the sources and structures of collagen. In addition, biological and mechanical properties of collagen-based biomaterials, their modification and application forms, and their interactions with host tissues are pinpointed. However, there is still no review about collagen-based biomaterials for tissue engineering. Therefore, we aim to summarize and discuss the progress of collagen-based materials for tissue regeneration applications in this review. We focus on the utilization of collagen-based biomaterials for bones, cartilages, skin, dental, neuron, cornea, and urological applications and hope these experiences and outcomes can provide inspiration and practical techniques for the future development of collagen-based biomaterials in related application fields. Moreover, future improving directions and challenges for collagen-based biomaterials are proposed as well.

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Ureteral reconstruction with reinforced collagen scaffolds in a porcine model

Cited by 13 publications

References 34 publications

Ureteral Reconstruction in Goats Using Tissue-Engineered Templates and Subcutaneous Preimplantation

Ureteral Reconstruction in Goats Using Tissue-Engineered Templates and Subcutaneous Preimplantation

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

Collagen-Based Biomaterials for Tissue Engineering

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