Ureteral Double-J Wire Stent Effectiveness after Endopyelotomy: An Animal Model Study

Abstract

Objectives: The aim of this experimental study was to assess the possibility of decreasing the size of the ureteral stents used after an endopyelotomy. To this end, an experimental study was performed which compared a ureteral double-J wire stent versus a standard 7F ureteral stent after endopyelotomy. Methods: Twenty healthy female pigs were randomly divided into 2 groups: group I (double pigtail ureteral stent 7F) and group II (lumenless ureteral double-J wire stent, Zebrastent™, 0.035 inches in diameter). Percutaneous, endoluminal ultrasonographic and fluoroscopic studies were analyzed during the 3 different phases of the study. The first phase included premodel documentation of normal urinary tracts and laparoscopic ureteropelvic junction (UPJ) obstruction induction. During the second phase, 6 weeks later, diagnosis and endopyelotomy were carried out. Sixteen weeks after the obstruction treatment, follow-up imaging studies and postmortem evaluations of all animals were performed. Results: After the sonographic and fluoroscopic assessments, we determined the success rate for each group: 80% for group I and 90% for group II. No significant statistical differences were evident in the evolution of the diameter of the UPJ between groups. Better healing of the UPJ and a lower level of retroperitoneal repercussions were seen in group II. Conclusions:The ureteral double-J wire stent (Zebrastent) has been shown to be highly effective after endopyelotomy. This means that it is possible to reduce the size of ureteral stents after endopyelotomy with the advantages that this entails. Double-J ureteral stents probably act as a scaffold rather than a mold.

Biodegradable Stent with mTOR Inhibitor-Eluting Reduces Progression of Ureteral Stricture

“…The majority of ureter stent studies used pigs as models. These studies tested different surgical procedures and types of ureteral stents [ 44 , 45 , 46 , 47 ]. Rabbits [ 48 , 49 ] and canines [ 32 ] have been used for pyeloplasty and inflammation within urinary tract reconstruction.…”

Methodology for the Development and Validation of New Stent Designs: In Vitro and In Vivo Models

“…4). Histological analysis may be performed for the analysis of biocompatibility, tissue damage and more specifically, of the ureteral healing provided with the stents [34,36,37]. In addition, intravesical and renal pressures in stented ureters have also been measured, as well as ureteral peristalsis and contractility [29,38,39].…”