Uremic Pruritus: A Review

Ponticelli, Claudio; Bencini, Pier Luca

doi:10.1159/000186696

Cited by 76 publications

(62 citation statements)

References 23 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the main cause of pruritus is unknown, uremia is the most important factor in these patients (7). Other factors, such as xerosis, increases in skin mast cells, hyperparathyroidism, high serum magnesium, and increased vitamin A, may lead to onset or may aggravate uremic pruritus (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…Other factors, such as xerosis, increases in skin mast cells, hyperparathyroidism, high serum magnesium, and increased vitamin A, may lead to onset or may aggravate uremic pruritus (7)(8)(9)(10)(11). Not only is the treatment of uremic pruritus complex (12), but dialysis also has a mild effect on it (13), as the severity of pruritus can increase on the day of dialysis therapy or on the following day (14).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Afrasiabifar¹,

Mehri²,

Hosseini³

2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Afrasiabifar¹,

Mehri²,

Hosseini³

2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

show abstract

“…The pruritic skin may appear normal except for dryness, but is often complicated by inflammatory lesions secondary to scratching 9 . Various therapeutic modalities have been developed for pruritus, especially associated with renal failure.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers

Jeong

Park

et al. 2010

Ann Dermatol

View full text Add to dashboard Cite

Background: Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms. Objective: In order to investigate the possible beneficial effects of topical n-3 fatty acid, oils extracted from chia (Salvia hispanica) seed were formulated into topical products, the effects of which were measured. Methods: Five healthy volunteers having xerotic pruritus symptoms and 5 patients with pruritus caused by either ESRD or diabetes were involved in this study. A topical formulation containing 4% chia seed oils were applied for an 8-week duration. Subjective itching symptoms were assessed on a 6-point scale, as were other skin functions, namely transepidermal water loss and skin capacitance. Results: After the 8 weeks of application, significant improvements in skin hydration, lichen simplex chronicus, and prurigo nodularis were observed in all patients. A similar improvement was also observed among healthy volunteers with xerotic pruritus. Improvement of epidermal permeability barrier function and skin hydration, represented by trans-epidermal water loss and skin capacitance, respectively, were also observed. No adverse effects were observed in all the tested patients and volunteers. Conclusion: Chia seed oil can be used as an adjuvant moisturizing agent for pruritic skin, including that of ESRD patients.

show abstract

“…The prevalence of CKD associated pruritus varies substantially in various studies ranging from 22-90% [7,29,[35][36][37]. Overall 85% of dialysis patients were affected with CKD itch in 1970s [7].…”

Section: Epidemiologymentioning

confidence: 99%

“…In the largest study the prevalence was calculated as 42% [38]. CKD associated pruritus is independent of age, sex, ethinicity, type of dialysis and underlying renal disease [35][36][37].…”

Section: Epidemiologymentioning

confidence: 99%

Uremic pruritus – a review

Pvs¹,

Pk²,

Nethra³

et al. 2016

Glob Dermatol

View full text Add to dashboard Cite

Uremic pruritus remains a frequent concern for hemodialysis patients with the most frustrating and disabling symptoms. The word uremic may denote that patients suffer from acute renal injury. Hence it is preferred to use the recent term "chronic kidney disease associated pruritus" (CKD-associated pruritus). The prevalence of CKD-associated pruritus in patients ranges from 15%-90% in various studies.Interestingly, in CKD associated pruritus the skin lesions are not found. The various skin lesions which range from excoriations, impetigo, linear crusts, papules and ulcers are secondary. Other co-existing diseases like cardiovascular diseases, diabetes, hypothyroidism, chronic liver or hematological diseases may challenge the diagnosis and management.The pathophysiology remains unexplained. There may be an imbalance between the antagonistic activities of µ-and] κ-opioid receptors. Itch sensation are correlated with the activation of certain areas in the brain, spatial and temporal aspects may be processed in the primary somatosensory cortex, planning of scratch response in the pre-motor and supplementary motor cortices, and affective and motivational aspects in the anterior cingulate cortex.

show abstract

Uremic Pruritus: A Review

Cited by 76 publications

References 23 publications

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers

Uremic pruritus – a review

Contact Info

Product

Resources

About