Uremic Exocrine Pancreopathy

Abu‐Alfa, Ali K.; Ivanovich, Peter; Mujais, Salim

doi:10.1159/000184885

Cited by 23 publications

(7 citation statements)

References 27 publications

(52 reference statements)

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“…Necropsy studies have shown a wide variety of pancre atic disorders in uremic patients: pancreatitis, fibrosis, fatty infiltration or hemosiderosis, among others [1][2][3]. Also, pan creatic exocrine function seems to be frequently disturbed, specially as refers to bicarbonate and amylase secretion [3].…”

Section: Discussionmentioning

confidence: 99%

“…Also, pan creatic exocrine function seems to be frequently disturbed, specially as refers to bicarbonate and amylase secretion [3]. These disorders are usually asymptomatic, but patients on dialysis present an increased incidence of acute pancre atitis, when compared with the general population.…”

Section: Discussionmentioning

confidence: 99%

“…Uremic patients present a high prevalence of structural and functional pancreatic disorders [1][2][3]. In addition, the incidence of acute pancreatitis is apparently increased in patients on dialysis, specially in those treated with perito neal dialysis (PD) [4].…”

Section: Introductionmentioning

confidence: 99%

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Chylous Ascites Associated with Acute Pancreatitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

Fontán

Pombo²,

Soto

et al. 1993

Nephron

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We report on a case of chylous ascites associated with acute pancreatitis secondary to gallbladder stone disease, in a patient undergoing continuous ambulatory peritoneal dialysis. The initial clinical presentation was one of bacterial peritonitis, with later appearance of chylous peritoneal drainage. Diagnosis was suggested by abdominal computed tomography and confirmed by surgical exploration. We discuss the main diagnostic keys of peritoneal dialysis-associated pancreatitis and the possible etiologic role of this entity in chylous ascites of these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Chylous Ascites Associated with Acute Pancreatitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

Fontán

Pombo²,

Soto

et al. 1993

Nephron

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“…Chronic renal failure is associated with structural ab normalities of the pancreas and with derangements in its exocrine function [1], Autopsy studies of these patients showed dilatation of acini, flattening of acinar cells and inspissated secretions (2] and ductular proliferation and acinar ductal metaplasia [3,4]. Pancreatic juice volume and enzyme secretion in response to stimulation are ei ther normal [5] or reduced [6], and basal bicarbonate secretion is decreased [7].…”

Section: Introductionmentioning

confidence: 99%

Acute Administration of Intact Parathyroid Hormone but Not Its Amino-Terminal Fragment Stimulates Volume of Pancreatic Secretion

El-Shahawy

Fadda²,

Wisner³

et al. 1991

Nephron

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Chronic renal failure is associated with structural and functional abnormalities of the exocrine system of the pancreas. Certain data suggest that the excess parathyroid hormone (PTH) in these patients may participate in the genesis of these pancreatic derangements. However, direct evidence that PTH exerts a direct effect on the exocrine pancreatic system is not well documented. The present study examined the effects of the intact molecule (1–84 PTH) and of the amino-terminal fragment (1–34 PTH) of the hormone on the basal output of pure pancreatic juice (PPJ) volume and pancreatic protein secretion in the rat. 1–84 PTH but not 1–34 PTH significantly (p < 0.01) stimulated the output of PPJ volume without an effect on protein secretion. The magnitude of this stimulatory effect of 1–84 PTH depended on the dose of the hormone administered, and it was related to its biological activity, since inactivation of PTH abolished its action on the output of PPJ volume. The simultaneous administration of the calcium channel blocker, verapamil, reduced but did not abolish the stimulatory effect of PTH on the volume of PPJ output. The data demonstrate that: (1) the ductal cells of the pancreatic acini are targets for PTH and (2) the action of the hormone on these cells is mediated, at least in part, via PTH-induced entry of calcium into the target cells.

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“…Se ha sugerido que la disminución o pérdida de la carga negativa glomerular podría jugar un papel importante en estos fenómenos. En sujetos normales la tripsina en sangre está en su mayoría como tripsinógeno libre con una proporción de 2:1 de la forma catiónica respecto a la anióni-ca (41,42). La forma catiónica, que es la que se mide en las determinaciones analíticas, sería la más susceptible ante una pérdida de la carga negativa glomerular (43,44).…”

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El páncreas en la uremia

Calvo

2001

An. Med. Interna (Madrid)

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Uremic Exocrine Pancreopathy

Cited by 23 publications

References 27 publications

Chylous Ascites Associated with Acute Pancreatitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

Chylous Ascites Associated with Acute Pancreatitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

Acute Administration of Intact Parathyroid Hormone but Not Its Amino-Terminal Fragment Stimulates Volume of Pancreatic Secretion

El páncreas en la uremia

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