Urei is the link between intra-bacterial urease of Helicobacter pylori and gastric survival

Weeks, David L.; Scott, David; Eskandari, Sepehr; Marcus, Elizabeth A.; Kim, Nayoung; Rektorschek, Marina; Buhmann, Anita; Schmitt, Barbara; Melchers, Klaus; Sachs, George

doi:10.1016/s0016-5085(00)84856-8

Gastroenterology

2000

DOI: 10.1016/s0016-5085(00)84856-8

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Urei is the link between intra-bacterial urease of Helicobacter pylori and gastric survival

David L. Weeks¹,

David Scott²,

Sepehr Eskandari³

et al.

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“…3). Periodic acid-silver staining detected carbohydrate (16) in the outer but not inner membrane fraction (17), confirming the validity of the separation (18). UreI contains six hydrophobic sequences, H1 to H6.…”

supporting

confidence: 61%

A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

Weeks

Eskandari

Scott

et al. 2000

Science

Self Cite

446

395

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Acidic media trigger cytoplasmic urease activity of the unique human gastric pathogen Helicobacter pylori. Deletion of ureI prevents this activation of cytoplasmic urease that is essential for bacterial acid resistance. UreI is an inner membrane protein with six transmembrane segments as shown by in vitro transcription/translation and membrane separation. Expression of UreI in Xenopus oocytes results in acid-stimulated urea uptake, with a pH profile similar to activation of cytoplasmic urease. Mutation of periplasmic histidine 123 abolishes stimulation. UreI-mediated transport is urea specific, passive, nonsaturable, nonelectrogenic, and temperature independent. UreI functions as a H+-gated urea channel regulating cytoplasmic urease that is essential for gastric survival and colonization.

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supporting

confidence: 61%

A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

Weeks

Eskandari

Scott

et al. 2000

Science

Self Cite

446

395

View full text Add to dashboard Cite

show abstract

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Urei is the link between intra-bacterial urease of Helicobacter pylori and gastric survival

Cited by 1 publication

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A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

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Urei is the link between intra-bacterial urease of Helicobacter pylori and gastric survival

Cited by 1 publication

References 0 publications

A H + -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

A H + -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

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A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization