Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns.

Cassell, Gail H.; Waites, K. B.; Watson, Harold L.; Crouse, Dennis T.; Harasawa, R

doi:10.1128/cmr.6.1.69-87.1993

Cited by 6 publications

(6 citation statements)

References 81 publications

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“…These species can be responsible of nongonococcal urethritis and pregnancy complications. Their incidence is higher in women compared to men [19], and their colonization was related to age, low socio-economic level, multiplicity of sexual partners, ethnicity, and oral contraceptives uses [20].…”

Section: Discussionmentioning

confidence: 99%

Detection of Ureaplasma Biovars and Subtyping of Ureaplasma parvum among Women Referring to a University Hospital in Morocco

Karim

Bouchikhi

Banani

et al. 2020

Infectious Diseases in Obstetrics and Gynecology

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Objectives. The aim of this study was to determine the prevalence of Ureaplasma biovars and Ureaplasma parvum (U. parvum) serovars, their associated risk factors, and genital STI-related symptoms. Methods. DNA obtained from cervical samples of 1053 women attending the department of Obstetrics and Gynecology and the laboratory of pathological anatomy of Hassan II university hospital of Fez, Morocco, was used to detect Ureaplasma biovars (U. urealyticum and U. parvum) and to subtype U. parvum by polymerase chain reaction (PCR). Results. Of the 1053 women examined, 25.4% (268/1053) were Ureaplasma positives. The rates of U. urealyticum and U. parvum were 12.1% (128/1053) and 7% (74/1053), respectively, and the copresence of these biovars was noted in 6.3% (66/1053) cases. The U. parvum subtyping revealed a predominance of the serovar 3/14 (61.4%). The association of demographics variables with Ureaplasma biovars was studied and shows that the age (“<30” years) seems to be a risk factor of Ureaplasma spp. and U. urealyticum carriage (OR 1.729, 95% CI [1.113-2.687] and OR 1.848, 95% CI [1.026-3.330], respectively). There was no difference in the prevalence of Ureaplasma type regarding symptoms. However, a significant association was found between U. parvum serovar 1 and infertility (P=0.011). Conclusion. This first study conducted in Morocco provides an idea on Ureaplasma biovars and U. parvum serovars circulating in this region, their associated risk factors, and genital STI-related symptoms. Therefore, further studies are required to clarify and confirm the pathogenic role of these Ureaplasma species.

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Section: Discussionmentioning

confidence: 99%

Detection of Ureaplasma Biovars and Subtyping of Ureaplasma parvum among Women Referring to a University Hospital in Morocco

Karim

Bouchikhi

Banani

et al. 2020

Infectious Diseases in Obstetrics and Gynecology

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“…Ureaplasma parvum and Ureaplasma urealyticum infection of the intra-amniotic cavity is typically associated with spontaneous PTD (Gray et al, 1992;Cassell et al, 1993;Horowitz et al, 1995). Therefore, all samples that tested positive for bacterial DNA by 16S rRNA gene qPCR (using primers optimized to improve coverage of Ureaplasma spp.)…”

Section: Ureaplasma Spp Were Not Detected In Mid-trimester Amniotic mentioning

confidence: 99%

Comparison of Bacterial DNA Profiles in Mid-Trimester Amniotic Fluid Samples From Preterm and Term Deliveries

et al. 2020

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“…Recently, findings of great interest were published indicating that M. hominis infections can produce bacteremia, pneumonia, meningitis, among other symptoms in newborns, but the significance of M. hominis as a pathogen causing neonatal meningitis remains unclear [ 230 ]. M. hominis rarely appears to invade the chorioamnios and amniotic fluid in the absence of other microorganisms, and data that support an independent role for this mycoplasma in histologic or clinical amnionitis is modest at best [ 231 , 232 ]. Recently reported M. hominis infections in newborns to indicate that the clinical findings, which can include pleocytosis with or without inflammatory reactions, are not always in agreement with the results obtained by testing of the CSF.…”

Section: – Special Considerations About the Neonates And Breastfeedingmentioning

confidence: 99%

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.

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Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns.

Cited by 6 publications

References 81 publications

Detection of Ureaplasma Biovars and Subtyping of Ureaplasma parvum among Women Referring to a University Hospital in Morocco

Detection of Ureaplasma Biovars and Subtyping of Ureaplasma parvum among Women Referring to a University Hospital in Morocco

Comparison of Bacterial DNA Profiles in Mid-Trimester Amniotic Fluid Samples From Preterm and Term Deliveries

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

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