This article investigates the political significance of the orientation of Western security relations around critical infrastructure (CI) and resilience planning. While the analysis is located in the International Political Sociology literature, it departs from recent biopolitical accounts of CIs and resilience. These accounts tend to present such apparatuses as closed, totalizing, and inevitably “successful” modes of governance. Rather, we argue that resilient CIs are open, vulnerable, and often absurd systems that continually falter, backfire, and often undermine themselves according to their own logic. By developing what we call a “molecular security” approach, we draw attention to the way in which life constantly evades capture. In this sense, we suggest, there is always an excess of “life” in biopolitics.