Urate changes in lean and obese boys during pubertal development

Garbagnati, Ersilia

doi:10.1016/s0026-0495(96)90054-2

Cited by 14 publications

(9 citation statements)

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“…This gain in mean serum uric acid concentration during adolescence can be found in populations of normal-weight and normouricemic adolescents as well as in samples of overweight adolescents with significantly elevated serum levels of uric acid [6][7] . Between the age of 15 and 17 years adult normal values are reached 3 " 5 .…”

Section: Introductionmentioning

confidence: 79%

Serum Uric Acid Levels in Obese Children and Adolescents: Linkage to Testosterone Levels and Pre-metabolic Syndrome

Denzer¹,

Muche²,

Mayer³

et al. 2003

Journal of Pediatric Endocrinology and Metabolism

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Hyperuricemia is part of the "metabolic syndrome". The aim of this study was to investigate the regulation and role of serum uric acid in the cardiovascular risk factor profile of obese children and adolescents. Serum levels of uric acid and selected risk factors and hormones were determined in 269 children aged 10.0-15.9 years with a BMI >90th percentile (mean 24.0 kg/m2, SD 5.43). Stepwise regression adjusted for age and sex revealed that testosterone (p < 0.0001), BMI (p < 0.0001), systolic blood pressure (p < 0.0017), triglycerides (p < 0.0345) and cholesterol/HDL ratio (p < 0.0393) were positively correlated with serum uric acid and accounted for 42.1% of the variance. Additional regression models with the same set of variables indicated that uric acid contributed significantly to levels of cholesterol/HDL, total cholesterol, BMI and systolic blood pressure, respectively. These results suggest a not yet described impact of androgens in the regulation of serum uric acid in obese children and adolescents. Furthermore, they show that uric acid is a reliable indicator for the "pre-metabolic syndrome" in obese youths.

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Section: Introductionmentioning

confidence: 79%

Serum Uric Acid Levels in Obese Children and Adolescents: Linkage to Testosterone Levels and Pre-metabolic Syndrome

Denzer¹,

Muche²,

Mayer³

et al. 2003

Journal of Pediatric Endocrinology and Metabolism

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“…Similar to serum uric acid, sUA levels appear to increase between adolescence and adulthood among both females and males, but with males having higher increases with age. In previous studies with adolescent and adult males, increased serum uric acid has been attributed to androgens and higher BMI (Feig et al, 2008;Garbagnati, 1996;Garbagnati & Boschetti, 1994).…”

Section: Discussionmentioning

confidence: 95%

“…Other research suggests that UA secretion has a developmental pattern, with levels increasing from adolescence to adulthood (Gillum, ; Harlan, Cornoni‐Hartley, Leaverton, ). Studies suggest the increase in UA during the transition to adulthood may be explained by the presence of pubertal hormones, vary by gender, and is associated with body weight (Feig, Kang, & Johnson, ; Garbagnati, ; Garbagnati & Boschetti, ). There are very few studies examining UA among children younger than 4 years old (with the exception of Grivna, Pruša, & Janda, ) and much less with racial/ethnic minorities in the United States (US).…”

Section: Introductionmentioning

confidence: 99%

Association between body mass index and salivary uric acid among Mexican‐origin infants, youth and adults: Gender and developmental differences

Martínez

Ruelas

2016

Developmental Psychobiology

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Uric acid (UA) is the end product of the metabolic breakdown of purine nucleotides. Recent studies have measured UA in saliva in relation to obesity and chronic disease risk. Given the increasing prevalence of metabolic syndrome among Latino youth, we examined gender and age differences in salivary uric acid (sUA) and weight in a sample of Mexican-origin children (n = 65, 2 months to 18 years, 49% female) and adults (n = 46, 19-58 years, 72% female). We measured weight, height, waist, and hip circumference and collected saliva samples (later assayed for sUA). Structural equation models estimated the relationship between age, developmental stage, and weight outcomes in relation to sUA levels between genders, while controlling for race. Results demonstrate that increased sUA levels were related to higher BMI percentiles in females of all ages (β = 0.43, p < .001). There were significant differences in sUA levels between developmental stages for girls, with female toddlers having the highest sUA levels (β = .28, p = .02). In an interaction between BMI z-score and gender between youth and adults, BMI has a larger effect on increasing sUA levels among younger girls (β = 0.27, p < .03) and adult women (β = 0.33, p = .02). Levels of sUA may be gender-specific in relation to BMI and developmental stage.

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“…While serum uric acid is described as stabilizing at lower levels in girls around the age of 11 years, uric acid levels in boys show an upward trend throughout adolescence (Costa et al 2002). These changes have been attributed to a progressive decline in renal uric acid clearance during puberty (Munan et al 1977;Stapleton et al 1978), and Garbagnati (1996) suggested that increased renal retention may be the main underlying mechanism enhancing uricemia. Our result showed that serum uric acid levels began to rise from the age of 11.1 -12.0 years and thereafter in Japanese boys and were higher than those in Japanese girls.…”

Section: Discussionmentioning

confidence: 99%