Uranium inhibits bone formation in physiologic alveolar bone modeling and remodeling

Ubios, A. M.; Guglielmotti, M.B.; Steimetz, Tammy; Cabrini, R. L.

doi:10.1016/s0013-9351(05)80191-4

Cited by 51 publications

(42 citation statements)

References 18 publications

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“…These findings suggest that bone is a primary reservoir for intramuscularly embedded DU fragments. Ubios (1991) observed acutely inhibited periodontal cortical bone formation in rats within 14 d after a single injection of uranyl nitrate (UNO 3 ) (2 mg/kg body weight). In addition, chronic intoxication, demonstrated by decreased bone formation and increased bone resorption, was observed 14, 30, and 60 d after a single dose (0.8 mg/kg body weight) .…”

Section: Bone and Musculoskeletal Toxicitymentioning

confidence: 99%

“…Because osteoblasts play a major role in bone resorption, it is possible that uranyl nitrate can directly affect these cells and their precursors by binding to cell membranes. Based on these data, uranium intoxication may be viewed as a potential contributor to osteoporosis or other osteopenic diseases in exposed individuals (Ubios, 1991). Alveolar wound healing serves as another useful model for the study of bone formation and can be considered a sensitive indicator of bone damage under various experimental conditions (Guglielmotti et al, 1985).…”

Section: Bone and Musculoskeletal Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Depleted and Natural Uranium: Chemistry and Toxicological Effects

Craft

Abu-Qare

Flaherty

et al. 2004

Journal of Toxicology and Environmental Health, Part B

361

231

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Depleted uranium (DU) is a by-product from the chemical enrichment of naturally occurring uranium. Natural uranium isInterest in depleted uranium (DU) is rapidly increasing as researchers realize its many potential military and civilian applications. Uranium, a naturally occurring heavy metal, is found in all soils, waters and rocks. Natural uranium is comprised of three radioactive isotopes: 238 U, 235 U, and 234 U. Of these, 235

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Section: Bone and Musculoskeletal Toxicitymentioning

confidence: 99%

Section: Bone and Musculoskeletal Toxicitymentioning

confidence: 99%

Depleted and Natural Uranium: Chemistry and Toxicological Effects

Craft

Abu-Qare

Flaherty

et al. 2004

Journal of Toxicology and Environmental Health, Part B

361

231

View full text Add to dashboard Cite

show abstract

“…In this model we observed after uranium acute intoxication, not only inhibition of bone formation but, inhibition of alveolar bone healing after extraction (Guglielmotti et al, 1987). Later, our group studied the toxic effect of uranyl nitrate on bone modeling and remodeling by performing histomorphometric measurements in the periodontal cortical bone in dental alveolus of mandibles of rats (Ubios et al, 1991). Our results revealed a decrease in bone formation in rats treated with uranium.…”

Section: The Bone Skeletal Systemmentioning

confidence: 90%

“…Because osteoblasts play a significant role in bone formation, it is possible that uranyl nitrate can directly affect these cells and their precursors by binding to cell membranes. Based on these data, uranium toxicity may be viewed as a potential contributor to osteoporosis or other osteopenic diseases in exposed individuals (Ubios et al, 1991). Bone growth was found to be impaired in tibiae (Ubios et al 1995) and mandibles (Ubios et al 1998) after exposure to uranyl nitrate and to uranium dioxide (Diaz Sylvester et al 2002).…”

Section: The Bone Skeletal Systemmentioning

confidence: 99%

Intracellular Metabolism of Uranium and the Effects of Bisphosphonates on Its Toxicity

Tasat¹,

Orona²,

Bozal³

et al. 2012

Cell Metabolism - Cell Homeostasis and Stress Response

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“…This dose appears to have been very high, given that almost all of the rats died within 15 days after receiving the injections. An earlier study showed that the effect of uranium injections on bone formation is dose dependent (Ubios et al (1991)). The information from these tests is insufficient to determine the effect on bone formation for veteran and civilian exposures during the 1991 Gulf War.…”

Section: Bone Damagementioning

confidence: 99%

Gulf war depleted uranium risks

Marshall

2007

J Expo Sci Environ Epidemiol

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US and British forces used depleted uranium (DU) in armor-piercing rounds to disable enemy tanks during the Gulf and Balkan Wars. Uranium particulate is generated by DU shell impact and particulate entrained in air may be inhaled or ingested by troops and nearby civilian populations. As uranium is slightly radioactive and chemically toxic, a number of critics have asserted that DU exposure has resulted in a variety of adverse health effects for exposed veterans and nearby civilian populations. The study described in this paper used mathematical modeling to estimate health risks from exposure to DU during the 1991 Gulf War for both US troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. The analysis indicated that only a few (B5) US veterans in vehicles accidentally targeted by US tanks received significant exposure levels, resulting in about a 1.4% lifetime risk of DU radiation-induced fatal cancer (compared with about a 24% risk of a fatal cancer from all other causes). These veterans may have also experienced temporary kidney damage. Iraqi children playing for 500 h in DU-destroyed vehicles are predicted to incur a cancer risk of about 0.4%. In vitro and animal tests suggest the possibility of chemically induced health effects from DU internalization, such as immune system impairment. Further study is needed to determine the applicability of these findings for Gulf War exposure to DU. Veterans and civilians who did not occupy DU-contaminated vehicles are unlikely to have internalized quantities of DU significantly in excess of normal internalization of natural uranium from the environment.

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Uranium inhibits bone formation in physiologic alveolar bone modeling and remodeling

Cited by 51 publications

References 18 publications

Depleted and Natural Uranium: Chemistry and Toxicological Effects

Depleted and Natural Uranium: Chemistry and Toxicological Effects

Intracellular Metabolism of Uranium and the Effects of Bisphosphonates on Its Toxicity

Gulf war depleted uranium risks

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