Uramil

Abstract

Uramil product: uramil

Access to the Surugatoxin Alkaloids: Chemo-, Regio-, and Stereoselective Oxindole Annulation

“…A solution of but-2-ynoic acid (801.0 mg, 9.52 mmol, 1.0 equiv), tert -butyl ( E )-(4-hydroxybut-2-en-1-yl)­carbamate (1.78 g, 9.52 mmol, 1.0 equiv), and DMAP (116.3 mg, 0.952 mmol, 0.1 equiv) in DCM (7.0 mL) was charged with DIC (1.5 mL, 9.62 mmol, 1.01 equiv). Additional but-2-ynoic acid (80.1 mg, 0.952 mmol, 0.1 equiv) was added after 50 min, and full consumption of alcohol was then observed.…”

“…A solution of 2,4,6-trichloro-5-nitropyrimidine (760.0 mg, 3.327 mmol, 1.0 equiv) was dissolved in DMF (20 mL) and cooled to −50 °C using a dry ice acetonitrile bath. Sodium tert -butoxide (639.1 mg, 6.655 mmol, 2.0 equiv) was added in portions, and the reaction was allowed to warm to room temperature over 45 min.…”