“…Shanbrom et al (1960) observed gastrointestinal symptoms in 41 of their 130 patients given uracil mustard; 12 had skin changes (including two with some alopecia), but these subsided when the drug was stopped and did not recur when it was restarted. Kennedy and Theologides (1961) noted anorexia in 5, nausea in 14, and vomiting in a further 16 of 49 patients treated with uracil mustard, while Spurr and Hayes (1960), out of 18 patients given the drug, noted four with gastrointestinal symptoms and one with a rash.…”