Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma

Brennan, Kelly; Johnson, Paul M.; Curtis, Heather; Arnason, Thomas

doi:10.1155/2019/1434838

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…With relation to the urachus, some hypotheses suggest a connection to ventral folding, ventral structures, and the yolk sac [5]. Among the 25 previous reported cases of MCTLMP [4][5][6][7][8], including this patient, the average tumor size is 4.7 cm. Gender does not appear to be a risk factor for MCTLMP occurrence with 13 of the reported cases observed in females and 12 in males.…”

Section: Discussionmentioning

confidence: 86%

“…Symptomatic presentation varies significantly, but most manifestations include some form of nonspecific abdominal pain [3]. Surgery comprised of excision with partial cystectomy remains the mainstay of care as it is typically curative for noninvasive localized disease [4]. Radiochemotherapeutic intervention has not been studied in randomized multicenter trials and is generally not utilized.…”

Section: Introductionmentioning

confidence: 99%

“…The inner wall of the urachus is lined by epithelium, which may transform into non-glandular, glandular, or mixed neoplasms [4]. Glandular neoplasms are further divided into adenomas, mucinous cystic tumor of low malignant potential (MCTLMP), and adenocarcinoma subtypes [4]. Mucinous cystic tumors, also known as cystadenomas, may be more commonly found in the appendix, ovaries, and pancreas.…”

Section: Introductionmentioning

confidence: 99%

“…It is believed that mucinous cystadenocarcinomas can develop from the cystadenomas and MCTLMP [1,3]. Less than 70 urachal neoplasms have been reported in the literature, among which include just 25 prior known cases of MCTLMP first reported in 2006 [1,4]. Seven of these reported tumors demonstrated Benjamin Schmeusser, Joseph Wiedemer and Dana Obery contributed equally to this work and are considered to be co-first authors.…”

Section: Introductionmentioning

confidence: 99%

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Urachal mucinous cystic tumor of low malignant potential in a polymorbid female: a case report and review of the literature

et al. 2022

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Neoplasms of the urachus are exceedingly rare, representing 0.17% of all bladder cancers. The mucinous cystic tumor of low malignant potential (MCTLMP) subtype is particularly rare with just 25 previous cases reported in the literature. Although rare, MCTLMPs are important to identify due to potential devastating complications and good cure rates with surgical removal. We present a 43 year old female with a nuanced constellation of comorbidities and confirmed MCTLMP following a workup for abdominal pain and irritative lower urinary tract symptoms. Notably, this tumor did not change in size over a 3-year course of serial imaging prior to surgical excision. This urachal MCTLMP represents roughly the 26th and one of the smallest of its subtype reported in the literature. This case illustrates the diagnosis and management of this rare urachal MCTLMP. Individual patient medical history, clinical considerations, and neoplasm characteristics are examined. Although rare, the potential for increased malignancy and potential complications necessitates surgical management and further investigation by the academic community.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urachal mucinous cystic tumor of low malignant potential in a polymorbid female: a case report and review of the literature

et al. 2022

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“…Rupture can occur, leading to focal or diffuse peritonitis and an acute abdomen [3,6]. Although rare, malignant trans-formation may occur [2,14,17]. Other urachal anomalies are diagnosed in early childhood, needing surgery when bladder infections are recurrent [19].…”

Section: Discussionmentioning

confidence: 99%

Urachal Cyst in a Bitch

Hertel

Silva

Evangelista

et al. 2019

Acta Scientiae. Vet.

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Background:The urachus is a tubular structure continuous with the urinary bladder and the allantois in foetal mammals. It serves as a communication between these two structures. At birth, it loses its function and undergoes atrophy by fibrous proliferation within the lumen. When this atrophy process fails at some point, congenital anomalies of the urachus occur. These anomalies are rare in animals, and to our knowledge, the urachal cyst has not yet been described in dogs. The present work is unique in that it reports a case of this congenital defect in a dog. Our aim is to increase awareness and to discuss the clinical presentation, the imaging techniques used, and the final diagnosis of this anomaly. Case: A 3-year-old bitch Pit Bull was presented for veterinary assistance to investigate recurrent pseudopregnancy and an irregular estrous cycle. The animal presented in good bodily condition, and the white blood count and clinical biochemistry were normal. At ultrasound, 2 tubular structures, filled by an echogenic fluid mimicking uterine topography, were found extending through the umbilical and hypogastric regions. No alterations in structure, echogenicity or echotexture of the other organs were observed, including the ovaries and uterus. On exploratory laparotomy, a cystic structure was found, with 2 segments: the larger one was on the left side, attached to the apex of the bladder by its caudal portion; the other was on the right side, attached to the spleen by its cranial portion and to the apex of the bladder by its caudal portion in connection with the left segment. The ovaries, uterus and uterine horns showed no macroscopic alterations. The structure was removed, and after analysis (macroscopic morphology, wall histopathology and biochemistry of the contained fluid), it was determined to be a urachal cyst. The animal recovered uneventfully. Discussion: Ultrasound is an important tool for the evaluation of reproductive cycle physiology and its pathologies. At first, the owner's complaint justified a fairly straightforward evaluation and clinical management of pseudopregnancy in a very healthy animal based on the history and clinical and complementary exams. However, ultrasound examination revealed two tubular structures filled with echogenic fluid in the lower abdomen. This made the case more complex, as these were interpreted as uterine horns by three different veterinarians, leading to the possibility of pyometra. The management of this condition must be cautious, since the animal's condition could rapidly deteriorate, necessitating an exploratory laparotomy. Based on the clinical presentation, macroscopic anatomy, fluid biochemistry and histological evaluations, the diagnosis of urachal cyst was proposed. Congenital anomalies occur when the urachus fails to obliterate. Four types can be found: patent urachus, urachal sinus, urachal diverticulum and urachal cyst. The urachal cyst occurs when the urachus encompasses a cyst-like structure that is closed to the umbilicus and the bladder lumen. The urachus be...

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Urachal mucinous cystic tumor of low malignant potential: a report of a rare case with literature review

George Moyo,

Dirilenoğlu,

Köy

2023

Surg Exp Pathol

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Neoplasms originating from the urachus are exceptionally uncommon, comprising only 0.17% of all bladder neoplasms. Among these, the mucinous cystic tumor of low malignant potential (MCTLMP) is particularly rare, with only 25 documented cases in medical literature. Despite their rarity, it is essential to identify MCTLMPs given the possibility of severe complications. Fortunately, surgical removal offers promising cure rates. In this report, A 40-year-old female patient presented to the hospital with abdominal pain. Subsequently, a CT scan showed a 9-cm cystic mass pressing the bladder. The lesion was surgically excised and histopathological examination was performed. Grossly, the specimen consisted of a cyst with a smooth external surface and mucinous content. Microscopically, the cyst was lined by columnar mucinous epithelial cells that included basally-located hyperchromatic nuclei and scattered Goblet cells consistent with an intestinal phenotype. The epithelial cells show mild atypia with focal papillary formations and flattening due to compression. Immunohistochemically, the epithelial tumor cells expressed cytokeratin 20, CDX2, beta-catenin (membranous); and were negative for cytokeratin 7. The location, histopathological, and immunohistochemical findings were consistent with a diagnosis of MCTLMP. In this report, we present an instance of urachal MCTLMP, which represents less than 30 cases documented in the medical literature. This case study marks the importance of early identification of MCTLMP due to their potential for severe complications, despite the tumor’s low malignant potential and to exclude more aggressive tumors with areas of intraepithelial or invasive carcinoma.

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Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma

Cited by 6 publications

References 31 publications

Urachal mucinous cystic tumor of low malignant potential in a polymorbid female: a case report and review of the literature

Urachal mucinous cystic tumor of low malignant potential in a polymorbid female: a case report and review of the literature

Urachal Cyst in a Bitch

Urachal mucinous cystic tumor of low malignant potential: a report of a rare case with literature review

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