Urachal adenocarcinoma

Aggarwal, Ajay; Agarwal, Samarth; Pandey, Siddharth; Sankhwar, Satyanarayan

doi:10.1136/bcr-2018-226207

Cited by 6 publications

(3 citation statements)

References 3 publications

(4 reference statements)

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“…Surgical approaches still played a role as the primary treatment for patients diagnosed with UrC without distant metastasis [16]. Furthermore, extended partial cystectomy with en bloc resection of the urachal tumor, the entire urachus, and umbilicus, and pelvic lymph node dissection was the recommended surgery approach applied by most urologists [13, 17, 18].…”

Section: Discussionmentioning

confidence: 99%

Clinical, Pathological, and Prognostic Analysis of Urachal Carcinoma

Shao

Liu

et al. 2021

Urol Int

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Objective: The aim of this study was to improve understanding the clinical, pathologic, and prognostic features of urachal carcinoma (UrC), a retrospectively descriptive study was done in 2 clinical centers. Methods: After excluding the 2 missed patients, the clinical and pathological data of 59 patients with UrC, who were diagnosed or treated at 2 clinical centers between 1986 and 2019, was retrospectively analyzed. SPSS 22.0 (IBM) and GraphPad Prism 8.0.1 were used for statistics and data visualization. Survival data were analyzed by the Kaplan-Meier method and Log-rank tests. Cox proportional hazards regression were performed for find risk factors on predicting the prognosis. Results: Of all 59 patients, 47 were male and 12 were female. The median age at diagnosis was 51.6 years (range: 22–84 years). Gross hematuria was the most common symptom (79.66%). The majority of urachal neoplasms were adenocarcinomas (94.92%). Forty-two patients (72.41%) underwent extended partial cystectomy with en bloc resection of the entire urachus. The mean follow-up was 52 months (3–277 months). Median overall survival was 52.8 months (4–93 months). The 3-year cancer-specific survival (CSS) rate and 5-year CSS rate were 69.1% and 61.2%. There was no significant difference among localized T stage, tumor histologic grade and surgical procedures in determining prognosis by survival analyze. While patients with high-risk TNM stage (local abdominal metastasis, lymph node metastasis, or distant metastasis) (p = 0.003) and positive surgical margin (p < 0.001) had significantly worse prognosis. Conclusions: The results indicate that high-risk TNM stage and positive surgical margin are risk predictors of prognosis. Localized T stage, histologic grade, and surgical procedure cause no significant effect on patient prognosis. The extended partial cystectomy is the recommended surgical approach for patients with UrC. Active multimodal treatments may improve the survival of patients with recurrent and metastatic disease.

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Section: Discussionmentioning

confidence: 99%

Clinical, Pathological, and Prognostic Analysis of Urachal Carcinoma

Shao

Liu

et al. 2021

Urol Int

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“…UC commonly lacks early clinical symptoms and this results in relatively late diagnosis of the disease whereas the carcinoma is already progressed to an advanced stage such as systemic metastasis at the time of beginning therapeutic intervention ( 7 ). The treatment methods of UC are different for localized or metastatic disease, but the current main therapy for localized UC is surgery including partial resection or radical resection ( 8 ). Many previous studies have reported that UC cases treated with surgical resection had a median survival of 48 months, and no definite difference in survival rates were observed according to different surgical modalities including partial and radical cystectomy ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

The Prognosis and Oncological Predictor of Urachal Carcinoma of the Bladder: A Large Scale Multicenter Cohort Study Analyzed 203 Patients With Long Term Follow-Up

Kim

et al. 2021

Front. Oncol.

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AimThis study evaluated the prognosis and survival predictors for bladder urachal carcinoma (UC), based on large scale multicenter cohort with long term follow-up database.MethodsA total 203 patients with bladder UC treated at 19 hospitals were enrolled. Clinical parameters on carcinoma presentation, diagnosis, and therapeutic methods were reviewed for the primary cancer and for all subsequent recurrences. The stage of UC was stratified by Mayo and Sheldon pathological staging system. Oncological outcomes and the possible clinicopathological parameters associated with survival outcomes were investigated.ResultsThe mean age of the patients was 54.2 years. Among the total of 203 patients, stages I, II, III, and IV (Mayo stage) were 48 (23.8%), 108 (53.5%), 23 (11.4%), and 23 (11.4%), respectively. Gross hematuria and bladder irritation symptoms were the two most common initial symptoms. The mean follow-up period was 65 months, and 5-year overall survival rates (OS), cancer-specific survival rates (CSS), and recurrence-free survival rates (RFS) were 88.3, 83.1, and 63.9%, respectively. For the patients with Mayo stage ≥III, OS, CSS, and RFS were significantly decreased to 38.0, 35.2, and 28.4%, respectively. The higher pathological stage (Mayo stage ≥III, Sheldon stage ≥IIIc), positive surgical margin (PSM), and positive lymphovascular invasion (PLM) were independent predictors of shorter OS, CSS, and RFS.ConclusionThe pathological stage, PSM, and PLM were significantly associated with the survival of UC patients, emphasizing an importance of the complete surgical resection of tumor lesion.

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“…Signet ring cell carcinoma can be of urachal origin and directly extend into the bladder. These tumours generally present as highgrade, high-stage tumours and have a uniformly poor prognosis [8] . The primary treatment is radical cystectomy; however, in the majority of cases there are regional or distant metastases at the time of presentation [needs more extensive surgical intervention], and the mean survival time is less than 20 months [10] .…”

Section: Introductionmentioning

confidence: 99%

Robotic assisted laparoscopic partial cystectomy and En bloc resection of urachus and umbilicus for rare case of mucin producing Urachal adenocarcinoma: A Case Report

Kuwaijo

Curran

O’Malley

2020

International Journal of Medical Arts

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Background: Urachal carcinoma accounts for <1% of all bladder cancers, 90% are adenocarcinomas, accounting for 10% of the bladders' adenocarcinomas. For its rarity, there is no consensus about the nomenclature, staging, diagnosis and treatment. Case report:We described a 42 years old male, who complained of post-voiding mucinous discharge for a long period [10 years]. after extensive clinical evaluation and radiologic investigation and cystoscopy, the diagnosis of an early stage urachal adenocarcinoma had been confirmed. It had been completely excised with no metastasis. The surgical resection of the tumour done en-bloc through laparoscopy, roboticassisted surgery. No chemotherapy nor radiotherapy had been indicated, the patient has been submitted to close follow-up, with our hoping look for recurrence of the disease. Excised specimen had been further submitted to histopathological and immunostaining examination. Histopathological grading had been done according to most recent staging systems [it confirmed the early staging mucinous adenocarcinoma of urachal origin]. Conclusion:Here we described our experience with a rare case report of mucinous cystadenoma of urachal origin, robot-assisted laparoscopic surgery and early stage of cancer permits partial cystectomy, good outcome with no need for chemical or radiotherapy.

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Urachal adenocarcinoma

Cited by 6 publications

References 3 publications

Clinical, Pathological, and Prognostic Analysis of Urachal Carcinoma

Clinical, Pathological, and Prognostic Analysis of Urachal Carcinoma

The Prognosis and Oncological Predictor of Urachal Carcinoma of the Bladder: A Large Scale Multicenter Cohort Study Analyzed 203 Patients With Long Term Follow-Up

Robotic assisted laparoscopic partial cystectomy and En bloc resection of urachus and umbilicus for rare case of mucin producing Urachal adenocarcinoma: A Case Report

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