Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer

Maeda, Tomoji; Irokawa, Masanori; Arakawa, Hiroshi; Kuraoka, Erika; Nozawa, Takashi; Tateoka, Ryoko; Itoh, Yoshiharu; Nakanishi, Takeo; Tamai, Ikumi

doi:10.1016/j.jsbmb.2010.06.014

Cited by 31 publications

(33 citation statements)

References 29 publications

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“…In fact, our primary target, SLCO1B3 is aberrantly expressed in a panel of cSCC from both UV induced and RDEB induced cSCC cell lines and tissue (Fig. 1), again in agreement with previous studies identifying SLCO1B3 expression in cancer (Maeda et al, 2010;Pressler et al, 2011;Svoboda et al, 2011). However, by pursuing the molecule responsible for RDEB we show that type VII collagen regulates the expression of SLCO1B3 in both RDEB cSCC and Fig.…”

Section: Discussionsupporting

confidence: 90%

“…OATP1B3 is normally expressed in the liver and is involved in the transport of bile salts, glutathione and other organic anions (Smith et al, 2005a;Hagenbuch and Gui, 2008). In agreement with our data, OATP1B3/SLCO1B3 is frequently upregulated in solid tumours including breast and colon Maeda et al, 2010;Pressler et al, 2011) and it has been suggested that OATP1B3 has therapeutic potential owing to its ability to transport a broad range of drugs, including methotrexate, paclitaxel, docetaxel, bromsulphalein (BSP) and pitavastatin (Smith et al, 2005b;Hagenbuch and Gui, 2008). OATP1B3 expression has been reported to associate with clinical outcome in a number of studies (Hamada et al, 2008;Lockhart et al, 2008) yet little data exist on the mechanism of expression or functional consequence.…”

Section: Introductionsupporting

confidence: 92%

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Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

Dayal

Cole

Pourreyron

et al. 2013

Journal of Cell Science

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Type VII collagen is the main component of anchoring fibrils, structures that are integral to basement membrane homeostasis in skin. Mutations in the gene encoding type VII collagen COL7A1 cause recessive dystrophic epidermolysis bullosa (RDEB) an inherited skin blistering condition complicated by frequent aggressive cutaneous squamous cell carcinoma (cSCC). OATP1B3, which is encoded by the gene SLCO1B3, is a member of the OATP (organic anion transporting polypeptide) superfamily responsible for transporting a wide range of endogenous and xenobiotic compounds. OATP1B3 expression is limited to the liver in healthy tissues, but is frequently detected in multiple cancer types and is reported to be associated with differing clinical outcome. The mechanism and functional significance of tumour-specific expression of OATP1B3 has yet to be determined. Here, we identify SLCO1B3 expression in tumour keratinocytes isolated from RDEB and UV-induced cSCC and demonstrate that SLCO1B3 expression and promoter activity are modulated by type VII collagen. We show that reduction of SLCO1B3 expression upon expression of full-length type VII collagen in RDEB cSCC coincides with acquisition of front-to-rear polarity and increased organisation of 3D spheroid cultures. In addition, we show that type VII collagen positively regulates the abundance of markers implicated in cellular polarity, namely ELMO2, PAR3, E-cadherin, B-catenin, ITGA6 and Ln332.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 92%

Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

Dayal

Cole

Pourreyron

et al. 2013

Journal of Cell Science

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“…The authors speculated that OATP1B3 overexpression may be associated with hormone-dependent growth mechanisms considering that OATP1B3 transports E3S. In line with these findings, subsequent studies have also suggested that OATP1B3 contributes to the growth of estrogen-dependent breast cancer (13,15). OATP1B3 is also reported to be expressed in prostate and colorectal cancers (16,17,99).…”

Section: Oatp1b3 (Gene Symbol Slco1b3)mentioning

confidence: 83%

“…Among the 11 human OATP members, seven (OATP1A2, OATP1B1, OATP1B3, OATP1C1, OATP2B1, OATP3A1, and OATP4A1) are shown to transport E3S (7,13). These OATPs may facilitate the uptake of E3S not only in major organs such as the liver, kidney, intestine, and brain but also in hormone-dependent cancers (13)(14)(15). Similar to E3S, dehydroepiandrosterone sulfate (DHEA-S) is transported by multiple OATPs (OATP1A2, OATP1B1, OATP1B3, and OATP2B1) and may gain entry to cells via these transporters (7).…”

Section: Role Of Oatps In the Disposition Of Substra Tes Implicated Imentioning

confidence: 99%

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

Thakkar

Lockhart

Lee

2015

AAPS J

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Abstract. The superfamily of organic anion-transporting polypeptides (OATPs, gene symbol SLCO) includes important transporters handling a variety of endogenous and xenobiotic substrates. Currently, 11 human OATPs are known and their substrates include endogenous hormones and their conjugates, anticancer drugs, and imaging agents. The contribution of OATPs to the in vivo disposition of these substrates has been extensively investigated. An accumulating body of evidence also indicates that the expression of some OATPs may be up-or downregulated in several types of cancers, suggesting potential pathogenic roles during the development and progression of cancer. Given that the role of OATPs in handling cancer therapeutics has been already covered by several excellent reviews, this review will focus on the recent progresses on the topic, in particular the role of OATPs in the disposition of anticancer drugs, the impact of OATP genetic variations on the function of OATPs, and the OATPs differentially expressed in cancer and their potential roles in cancer development, progression, and treatment.

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“…We have previously shown that transport of estrone 3-sulfate via OATPs sustains the growth of hormone-dependent human breast cancer cells [7,8], because estrone-3-sulfate can be hydrolyzed by steroid sulfatase (STS) to estrone and eventually estradiol. We recently showed that OATP1B3 contributes to estrone 3-sulfate uptake in estrogen receptor-positive human breast cancer MCF-7 cells [9]. In addition to estrone 3-sulfate, these OATPs translocate dehydroepiandrosterone sulfate (DHEAS) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions

Arakawa

Nakanishi

Yanagihara

et al. 2012

Biochemical Pharmacology

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The biological mechanisms underlying castration resistance of prostate cancer are not fully understood. In the present study, we examined the role of organic anion transporting polypeptides (OATPs) as importers of dehydroepiandrosterone sulfate (DHEAS) into cells to support growth under androgen-depleted conditions. Cell growth and mRNA expression of OATP genes were studied in human prostate cancer LNCaP and 22Rv1 cells under androgen-depleted conditions. The stimulatory effect of DHEAS on cell growth was investigated in LNCaP cells in which OATP1A2 had been silenced. Growth of both cell lines was stimulated by DHEAS and the effect was attenuated by STX64, an inhibitor of steroid sulfatase which can covert DHEAS to DHEA. OATP1A2 mRNA expression was increased most prominently among various genes tested in LNCaP cells grown in androgen-depleted medium. Similar results were obtained with 22Rv1 cells. Furthermore, the characteristics of

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Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer

Cited by 31 publications

References 29 publications

Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions

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