Uptake, retention and internalization of quantum dots in Daphnia is influenced by particle surface functionalization

Feswick, April; Griffitt, Robert J.; Siebein, Kerry; Barber, David S.

doi:10.1016/j.aquatox.2013.01.002

Cited by 65 publications

(44 citation statements)

References 45 publications

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“…TEM studies have demonstrated the presence of ENPs in the gut of D. magna 104, 105, 106. Confocal microscopy images of whole organisms suggested translocation of, for example, polystyrene ENPs107 and quantum dots 108. Dark‐field optical microscopy has also been used to show the ingestion of Ag rods in D. magna 109.…”

Section: Uptake Internalization and Translocation Of Engineered Namentioning

confidence: 99%

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

et al. 2016

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The number of products on the market containing engineered nanoparticles (ENPs) has increased significantly, and concerns have been raised regarding their ecotoxicological effects. Environmental safety assessments as well as relevant and reliable ecotoxicological data are required for the safe and sustainable use of ENPs. Although the number of publications on the ecotoxicological effects and uptake of ENPs is rapidly expanding, the applicability of the reported data for hazard assessment is questionable. A major knowledge gap is whether nanoparticle effects occur when test organisms are exposed to ENPs in aquatic test systems. Filling this gap is not straightforward, because of the broad range of ENPs and the different behavior of ENPs compared to “ordinary” (dissolved) chemicals in the ecotoxicity test systems. The risk of generating false negatives, and false positives, in the currently used tests is high, and in most cases difficult to assess. This Review outlines some of the pitfalls in the aquatic toxicity testing of ENPs which may lead to misinterpretation of test results. Response types are also proposed to reveal potential nanoparticle effects in the aquatic test organisms.

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Section: Uptake Internalization and Translocation Of Engineered Namentioning

confidence: 99%

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

et al. 2016

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“…Daphnids naturally ingest particulates from the water column or sediment and have been previously shown to readily uptake and accumulate NPs in the gut within 6-12 h after exposure. 60 We monitored the uptake of QDs and gH625-QDs until 24 h (30′, 60′, 90′, 6 and 24 h; Figure 5). We noticed that D. magna actively takes up and excretes QDs; in particular, both the ingestion and the excretion of QDs and gH625-QDs were very fast, probably because of their active filter-feeding mechanisms ( Figure 5).…”

Section: Uptake On D Magnamentioning

confidence: 99%

<em>Daphnia magna</em> and<em> Xenopus laevis</em> as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

Galdiero¹,

Falanga²,

Siciliano³

et al. 2017

IJN

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The use of quantum dots (QDs) for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely used for drug delivery studies. We evaluated and compared the effects of QDs and gH625-QDs on the survival, uptake, induction of several responsive pathways and genotoxicity in D. magna , and we found that QDs coating plays a key role. Moreover, studies on X. laevis embryos allowed to better understand their cell/tissue localization and delivery efficacy. X. laevis embryos raised in Frog Embryo Teratogenesis Assay- Xenopus containing QDs or gH625-QDs showed that both nanoparticles localized in the gills, lung and intestine, but they showed different distributions, indicating that the uptake of gH625-QDs was enhanced; the functionalized QDs had a significantly lower toxic effect on embryos’ survival and phenotypes. We observed that D. magna and X. laevis are useful in vivo models for toxicity and drug delivery studies.

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“…Though a number of reports are available [12,18,19] on the adverse effect of TiO 2 or C 60 nanoparticles and CNT on the Daphnia sp., studies investigating impacts of sulphide nanoparticles on Daphnia sp. are very few [27,28]. Any systematic study on the adverse effect of ZnS nanoparticles on the Daphnia sp.…”

Section: Introductionmentioning

confidence: 99%

Harmful Impact of ZnS Nanoparticles on Daphnia sp. in the Western Part (Districts of Bankura and Purulia) of West Bengal, India

Bhattacharjee

Chatterjee

2013

ISRN Nanomaterials

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ZnS nanoparticles of different sizes are synthesized employing a simple wet chemical method. These nanoparticles are used to study their impact on the Daphnia sp. through traditional toxicity tests. The percentage of mortality is found to increase initially with increasing nanoparticle concentration or exposure time and is finally found to saturate for higher concentrations or exposure times. Mortality is found to be higher for smaller particles. Hopping frequency and heart rate are also found to increase with increasing nanoparticle exposure time for a fixed nanoparticle concentration. These observations can be attributed to the enhanced surface photooxidation property of the ZnS nanoparticles. Thus the present study will help people to understand the hitherto unknown harmful impact of ZnS nanoparticles on aquatic organisms in the western part of West Bengal (Bankura and Purulia districts), India.

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Uptake, retention and internalization of quantum dots in Daphnia is influenced by particle surface functionalization

Cited by 65 publications

References 45 publications

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

<em>Daphnia magna</em> and<em> Xenopus laevis</em> as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

Harmful Impact of ZnS Nanoparticles on Daphnia sp. in the Western Part (Districts of Bankura and Purulia) of West Bengal, India

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