Uptake of the Carborane Derivative of Cholesteryl Ester by Glioma Cancer Cells Is Mediated Through LDL Receptors

Pan, Guangliang; Oie, Shigeharu; Lü, Donghao

doi:10.1023/b:pham.0000033014.04820.a7

Cited by 14 publications

(6 citation statements)

References 16 publications

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“…MA), is being used clinically in photodynamic therapy for age-related macular degeneration (Ichikawa 2004). Verteporfin is transported in the plasma primarily by lipoproteins (especially low-density lipoproteins), are known to deliver hydrophobic materials to tumor cells (de Smidt et al 1993;Koller-Lucae et al 1999;Pan et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Abdelkawi

Hassan²

2012

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Abstract. The aim of the present study was to evaluate the change in corneal protein and oxidative stress state after using photodynamic therapy (PDT) for treatment of experimental corneal neovascularization (NV) with benzoporphyrin derivative (BPD). One group was considered as control (N = 10 eyes), corneal NV was induced in 25 New Zealand male rabbits (N = 50 eyes) after placing silk sutures in the corneal limbus. Five rabbits with corneal NV were left without any treatment, and 20 rabbits were administered by intravenous injection with Verteporfin at a dose of 1.5 mg/kg. Diode laser (660 nm) was applied for 5 minutes with a power of 50 mW/cm 2 . For a period of 4 weeks, five rabbits were selected and sacrificed weekly (N = 10 eyes each). The corneas were isolated for determination of protein content, SDS-PAGE, total antioxidant capacity (TAC), total oxidative capacity (TOC), malondialdhyde (MDA) and oxidative stress index (OSI). The results indicated that corneal NV induced changes in the content and composition on the corneal protein and gradual improvement of the cornea after the 3 rd and 4 th week of PDT was detected. Furthermore, the oxidative/antioxidative balance shifted towards the antioxidative status that helped to prevent further damage.

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Section: Discussionmentioning

confidence: 99%

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Abdelkawi

Hassan²

2012

gpb

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“…Our previous observations demonstrated that the carborane derivatives had a potent selective inhibition effect on the proliferation of the cancer cell lines and no effect on normal cell lines [37]. It was also observed that carborane derivatives can lead to specific binding modalities with macromolecules, such as myoglobin [38], hemoglobin [39], nicotinamide phosphoribosyltranferase [40], low-density lipoprotein [41], relevant carborane ligands had been considered as effective pharmacophores as non-BNCT anticancer agents [42][43][44]. Based on these considerations, it is possible to readily utilize the novel carborane derivatives to target and distinguish different kinds of cells for the specific cancer diagnostics and treatment.…”

Section: Specific Recognition Of Cancer Cellsmentioning

confidence: 99%

Droplet electrochemical study of the pH dependent redox behavior of novel ferrocenyl-carborane derivatives and its application in specific cancer cell recognition

Shah

et al. 2015

Analytica Chimica Acta

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“…31,32) However, the purpose of liposomal formulation in this study was not for reducing side effects, but for making injectable form of hydrophobic drugs. 33) Furthermore, it is possible that rhinacanthins transferred to serum lipoprotein effectively accumulated in tumor tissues, since lipoproteins, especially low density lipoproteins, are known to deliver hydrophobic materials to tumor cells. [33][34][35][36] In the present study, the results demonstrated for the first time that rhinacanthins-N, -Q and -C entrapped in liposomes showed antiproliferative activities against HeLaS3 cells: The activities were slightly higher than that of free drugs after 24-and 48-exposure.…”

Section: Fig 3 Antiproliferative Activities Of Liposomal Rhinacanthmentioning

confidence: 99%

Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus KURZ.

Siripong

Yahuafai

Shimizu

et al. 2006

Biological & Pharmaceutical Bulletin

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Rhinacanthus nasutus KURZ. (family Acanthaceae), has been used in Thai traditional medicine for the treatment of various diseases such as eczema, pulmonary tuberculosis, herpes, hepatitis, diabetes, hypertension and various skin diseases, and its active components were widely investigated. 1-7)R. nasutus KURZ. has also been used for cancer treatment. [8][9][10] The main bioactive compounds were revealed to be naphthoquinone; rhinacanthins (A-D, G-Q), rhinacanthone and lignan groups. [1][2][3][4][5][6][7][8]10,11) Antitumor activity of R. nasutus KURZ. extracts,8) and that of rhinacanthone in the in vivo study were reported. 11) We previously reported that rhinacanthins-M, -N and -Q and related naphthoquinone esters as well as synthetic compounds, 1,2-naphthoquinones and 1,4-naphthoquinones, selectively suppressed the growth of KB, HeLa and HepG2 human cancer cells, and normal Vero cells. 12,13) We also performed mechanistic study and observed that synthetic rhinacanthins-N and -Q inhibited DNA topoisomerase II.13) A naphthoquinone compound b-lapachone, that was also derived from natural products and has a similar structure to rhinacanthone, was reported to be a potent inhibitor of DNA topoisomerase I and II, [14][15][16] and to induce apoptosis of various cancer cells. [17][18][19][20][21] Recently, we observed that rhinacanthins-C, -N and -Q suppressed human cervical carcinoma HeLaS3 cells through induction of apoptosis. 22)Therefore, in the present study, we attempted to determine actual antitumor activity of rhinacanthins in tumor-bearing mice.Since rhinacanthins-C, -N and -Q are hydrophobic compounds, they are not able to inject into bloodstream without solubilization. For in vivo use of the drugs, we attempted to solubilize them in liposomes. By the way, liposomes have been widely used in the field of drugs delivery systems (DDS): Liposomalization reduces side effects and toxicities of drugs encapsulated, and improves their bioavailability. Therefore, liposomes tended to be used for cancer treatment, since most of anticancer drugs accompany severe side effects. [23][24][25] Furthermore, liposomes with long circulating characteristics are known to accumulate in interstitial spaces of tumor tissues of which blood vessels are highly permeable. 26,27) For the purpose of DDS, liposomes having rather rigid lipid bilayer are favorable, and they are usually composed of phospholipids with saturated fatty acyl chains and cholesterol. On the other hand, liposomes have been used for the injection of hydrophobic drugs, since hydrophobic materials can be encapsulated into the lipid bilayer of the liposomes. For example, Visudyne, a liposomal formulation of benzoporphyrin derivative monoacid ring A (BPD-MA), is being used clinically in photodynamic therapy for age-related macular degeneration. In Visudyne, liposomes are used as a "solvent" of BPD-MA for the purpose of injection of the drug into bloodstream.28) In such case, liposomes having rather fluid lipid bilayer are used, and the injected drug in the bloodstream is t...

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Uptake of the Carborane Derivative of Cholesteryl Ester by Glioma Cancer Cells Is Mediated Through LDL Receptors

Abstract: These results strongly suggested that the cellular uptake of BCH (in liposomal formulation) by SF-763 and SF-767 glioma cell lines is mediated through LDL receptors.

Cited by 14 publications

References 16 publications

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Droplet electrochemical study of the pH dependent redox behavior of novel ferrocenyl-carborane derivatives and its application in specific cancer cell recognition

Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus KURZ.

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Uptake of the Carborane Derivative of Cholesteryl Ester by Glioma Cancer Cells Is Mediated Through LDL Receptors

Abstract: These results strongly suggested that the cellular uptake of BCH (in liposomal formulation) by SF-763 and SF-767 glioma cell lines is mediated through LDL receptors.

Cited by 14 publications

References 16 publications

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Droplet electrochemical study of the pH dependent redox behavior of novel ferrocenyl-carborane derivatives and its application in specific cancer cell recognition

Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus KURZ.

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Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization