Uptake of ochratoxin A by slices of pig kidney cortex

Friis, Christian; Brinn, R.; Hald, Birthe

doi:10.1016/0300-483x(88)90205-3

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…Friis et al [19] also found, by using pig renal cortical slices, that OTA enters proximal tubular cells by the common organic anion transport system for PAH and phenolsulphophthalein (PSP).…”

Section: Ota Transport Systems In Classical Studiesmentioning

confidence: 99%

Molecular Mechanism of Ochratoxin A Transport in the Kidney

Anzai

Jutabha

Endou

2010

Toxins

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The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of multispecific organic anion transporters have been identified: organic anion transporters (OATs), organic anion-transporting polypeptides (OATPs), oligopeptide transporters (PEPTs), and ATP-binding cassette (ABC) transporters, such as MRP2 and BCRP. These renal transporters mediate the transmembrane transport of OTA and play a pivotal role in the development of OTA-induced nephrotoxicity.

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Section: Ota Transport Systems In Classical Studiesmentioning

confidence: 99%

Molecular Mechanism of Ochratoxin A Transport in the Kidney

Anzai

Jutabha

Endou

2010

Toxins

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“…When barrows ingested feed containing 2,000 ppm of ochratoxin from 7 to 11 wk of age, they gained poorly and their kidney weight and function was altered (Harvey et al, 1989a). That the kidney is a main target for ochratoxin is demonstrated by selective uptake of ochratoxin by the proximal tubules of pig kidney cortex (Friis et al, 1988). Overall, the occurrence of ochratoxin in feedstuffs in the United States is low and poses little threat to our food supply.…”

Section: Ochratoxinmentioning

confidence: 99%

Mycotoxins and reproduction in domestic livestock1

Diekman

Green

1992

Journal of Animal Science

314

161

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Molds are parasitic plants that are ubiquitous in livestock feedstuffs. Even though molds themselves reduce the quality of grains, their synthesis of chemical substances termed mycotoxins causes the greatest monetary loss to the animal industry. Five major mycotoxins that impair growth and reproductive efficiency in North America are aflatoxins, zearalenone, deoxynivalenol, ochratoxin, and ergot. Aflatoxins are produced by Aspergillus flavus and Aspergillus parasiticus. Consumption of grains containing aflatoxins by swine affects reproduction indirectly by reducing feed intake and growth. In swine, aflatoxins impair liver and kidney function, delay blood clotting, increase susceptibility to bruising, and interfere with cellular humoral immune systems. Ruminants are comparatively resistant to aflatoxicosis, but presence of aflatoxins in milk of dairy cows is closely monitored for human safety. Depending on environmental conditions, Fusarium roseum can produce either zearalenone or deoxynivalenol. Days 7 to 10 postmating seem to be a critical period of gestation for zearalenone to exert its detrimental actions on early embryonic development. Presence of deoxynivalenol in swine feedstuffs decreases feed intake, causes feed refusal, and induces occasional vomiting. Several species of Penicillium and Aspergillus produce ochratoxin, a mycotoxin that causes necrosis of kidney tissue. Ergot alkaloids produced by Claviceps purpurea on wheat can cause reproductive problems and are associated with lactational failure in swine. Various methods have been developed to remove mycotoxins from infected feedstuffs. Chemical analyses in laboratories as well as diagnostic kits suitable for use at the elevator or farm can be used successfully to identify which mycotoxins are present in suspect feedstuffs.

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“…Examples of this phenomenon are inhibition of PAH uptake by pig renal cortical slices (ref. 98) at an ochratoxin A concentration of lo-' M and inhibition of PAH uptake by renal brush borders and basolateral membrane vesicle of canine kidney cortices with IC,, values of 2.0 and 3.2 x lo+ M ochratoxin A, respectively (ref. 99).…”

Section: )mentioning

confidence: 99%