Uptake of bone-seekers is solely associated with mineralisation! A study with 99mTc-MDP, 153Sm-EDTMP and 18F-fluoride on osteoblasts

Toegel, Stefan; Hoffmann, Oskar; Wadsak, Wolfgang; Ettlinger, Dagmar E.; Mien, Leonhard‐Key; Wiesner, Karoline; Nguemo, Joseph; Viernstein, Helmut; Kletter, Kurt; Dudczak, Robert; Mitterhauser, Markus

doi:10.1007/s00259-005-0026-x

Cited by 75 publications

(44 citation statements)

References 7 publications

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“…Localization of bone density around TKA is rather inaccurate and broad. The bone tracer is directed towards bone-forming minerals, which are produced by active osteoblasts [18].…”

Section: Discussionmentioning

confidence: 99%

Clinical value of SPECT/CT in the painful total knee arthroplasty (TKA): a prospective study in a consecutive series of 100 TKA

Hirschmann

Amsler

Rasch

2015

Eur J Nucl Med Mol Imaging

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“…Localization of bone density around TKA is rather inaccurate and broad. The bone tracer is directed towards bone-forming minerals, which are produced by active osteoblasts [18].…”

Section: Discussionmentioning

confidence: 99%

Clinical value of SPECT/CT in the painful total knee arthroplasty (TKA): a prospective study in a consecutive series of 100 TKA

Hirschmann

Amsler

Rasch

2015

Eur J Nucl Med Mol Imaging

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“…In contrast, most guidelines recognize that patients with bone metastases should forgo local therapy to avoid unnecessary side effects and be treated with systemic therapy instead (5). Early metastases to bone may be missed with bone scanning because this technique relies on osteoblastic activity (mineralization) rather than detection of actual tumor cells (6). A true and sensitive measure of the presence of disease in bone should lead to earlier detection of metastatic spread and a more robust measure of changes in tumor burden that could guide patient management.…”

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confidence: 99%

First-in-Man Evaluation of 2 High-Affinity PSMA-Avid Small Molecules for Imaging Prostate Cancer

Barrett¹,

et al. 2013

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This phase 1 study was performed to determine the pharmacokinetics and ability to visualize prostate cancer in bone, soft-tissue, and the prostate gland using 123 I-MIP-1072 and 123 I-MIP-1095, novel radiolabeled small molecules targeting prostate-specific membrane antigen. Methods: Seven patients with a documented history of prostate cancer by histopathology or radiologic evidence of metastatic disease were intravenously administered 370 MBq (10 mCi) of 123 I-MIP-1072 and 123 I-MIP-1095 2 wk apart in a crossover trial design. 123 I-MIP-1072 was also studied in 6 healthy volunteers. Whole-body planar and SPECT/CT imaging was performed and pharmacokinetics studied over 2-3 d. Target-to-background ratios were calculated. Absorbed radiation doses were estimated using OLINDA/EXM. Results: 123 I-MIP-1072 and 123 I-MIP-1095 visualized lesions in soft tissue, bone, and the prostate gland within 0.5-1 h after injection, with retention beyond 48 h. Target-to-background ratios from planar images averaged 2:1 at 1 h, 3:1 at 4-24 h, and greater than 10:1 at 4 and 24 h for SPECT/CT. Both agents cleared the blood in a biphasic manner; clearance of 123 I-MIP-1072 was approximately 5 times faster. 123 I-MIP-1072 was excreted in the urine, with 54% and 74% present by 24 and 72 h, respectively. In contrast, only 7% and 20% of 123 I-MIP-1095 had been renally excreted by 24 and 72 h, respectively. Estimated absorbed radiation doses were 0.054 versus 0.110 mGy/MBq for the kidneys and 0.024 versus 0.058 mGy/MBq for the liver, for 123 I-MIP-1072 and 123 I-MIP-1095, respectively. Conclusion: 123 I-MIP-1072 and 123 I-MIP-1095 detect lesions in soft tissue, bone, and the prostate gland at as early as 1-4 h. These novel radiolabeled small molecules have excellent pharmacokinetic and pharmacodynamic profiles and warrant further development as diagnostic and potentially when labeled with 131 I therapeutic radiopharmaceuticals.

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“…18 F-fluoride ion, a positron-emitting isotope, has been shown to deposit preferentially at the surface of bone, where the greatest activity of remodeling and turnover are seen [32,33]. 18 F-fluoride ion exchanges with hydroxyl groups on hydroxyapatite to form fluoroapatite, which subsequently incorporates into the formation of bone matrix [33,34]. The uptake of 18 Ffluoride tracer correlates with skeletal blood flow and has been shown to exhibit superior pharmacokinetic properties compared to 99m Tc-labeled biphosphonates [35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model

Hsu

Feeley

Krenek

et al. 2007

Eur J Nucl Med Mol Imaging

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Purpose-Currently available diagnostic techniques can be unreliable in the diagnosis of delayed fracture healing in certain clinical situations, which can lead to increased complication rates and costs to the health care system. This study sought to determine the utility of positron emission tomography (PET) scanning with 18 F-fluoride ion, which localizes in regions of high osteoblastic activity, and 18 F-fluorodeoxyglucose (FDG), an indicator of cellular glucose metabolism, in assessing bone healing in a rat femur fracture model. Methods-Fractureswere created in the femurs of immuno-competent rats. Animals in group I had a fracture produced via a manual three-point bending technique. Group II animals underwent a femoral osteotomy with placement of a 2-mm silastic spacer at the fracture site. Fracture healing was assessed with plain radiographs, 18 F-fluoride, and 18 F-FDG PET scans at 1, 2, 3, and 4-week time points after surgery. Femoral specimens were harvested for histologic analysis and manual testing of torsional and bending strength 4 weeks after surgery.Results-All fractures in group I revealed abundant callus formation and bone healing, while none of the nonunion femurs were healed via assessment with manual palpation, radiographic, and histologic evaluation at the 4-week time point. 18 F-fluoride PET images of group I femurs at successive 1-week intervals revealed progressively increased signal uptake at the union site during fracture repair. In contrast, minimal tracer uptake was seen at the fracture sites in group II at all time points after surgery. Data analysis revealed statistically significant differences in mean signal intensity between groups I and II at each weekly interval. No significant differences between the two groups were seen using 18 F-FDG PET imaging at any time point.Conclusion-This study suggests that 18 F-fluoride PET imaging, which is an indicator of osteoblastic activity in vivo, can identify fracture nonunions at an early time point and may have a role in the assessment of longitudinal fracture healing. PET scans using 18 F-FDG were not helpful in differentiating metabolic activity between successful and delayed bone healing.

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Uptake of bone-seekers is solely associated with mineralisation! A study with 99mTc-MDP, 153Sm-EDTMP and 18F-fluoride on osteoblasts

Cited by 75 publications

References 7 publications

Clinical value of SPECT/CT in the painful total knee arthroplasty (TKA): a prospective study in a consecutive series of 100 TKA

Clinical value of SPECT/CT in the painful total knee arthroplasty (TKA): a prospective study in a consecutive series of 100 TKA

First-in-Man Evaluation of 2 High-Affinity PSMA-Avid Small Molecules for Imaging Prostate Cancer

The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model

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