Uptake of and adherence to oral pre-exposure prophylaxis among adolescent girls and young women at high risk of HIV-infection in Kampala, Uganda: A qualitative study of experiences, facilitators and barriers

Abstract

Background There is limited information on factors that influence oral pre-exposure prophylaxis (PrEP) uptake and adherence among adolescent girls and young women (AGYW). We conducted a qualitative methods study to explore experiences, facilitators and barriers of PrEP uptake and adherence to PrEP among AGYW at risk of Human Immunodeficiency Virus (HIV) infection in Kampala, Uganda. Methods This study was nested in a prospective cohort study that offered daily oral PrEP to AGYW. Between April 2019 and October 2020 we conducted in-depth interviews with 26 AGYW aged 14–24 years who had been offered or had been using PrEP for at least 6 months, including PrEP adherers (8), non-adherers (8) and those who had declined PrEP (10). After 12 months, follow-up interviews were conducted with 12 AGYW who had adhered to PrEP and those who had dropped it. Thematic analysis was conducted and data were further examined and categorized into the 5 constructs of the Socio-Ecological Model (SEM). Results PrEP uptake and adherence were facilitated by factors including: perceptions that one’s own or partner’s sexual behaviour was high risk, a negative attitude towards condoms, social support and wanting to maintain a negative HIV status after receiving a negative HIV test result. Good adherence to PrEP was enabled by effective counselling, support tools such as alarms and phone reminders and incentives like free treatment for STIs and other illnesses during study visits. Barriers to uptake included: anxiety about the pill burden, perceptions of being too young for PrEP and fear of being labelled `prostitute’ or `HIV positive’. Poor adherence was attributed to doubt over the efficacy of PrEP as a result of beliefs that because HIV was incurable, no medicine could prevent it. Alcohol use, side effects experienced, and mobility all had a negative impact on adherence. The majority of PrEP users reported feeling safe as a result of using PrEP which had both good and negative implications on their sexual behaviour, specifically the number of sexual partners and condom use. Conclusion Addressing community misconceptions to maximize uptake of PrEP among AGYW is important. Targeted education messages, and counselling to address misconceptions in ways that capture the attention of AGYW in communities are required.

Equipping providers to offer novel MPTs: Developing counseling messages for the Dual Prevention Pill in clinical studies and beyond

“…End-user research with potential DPP users, providers and male partners found that side effects are one of the largest concerns of both prospective DPP clients and providers ( 56 ), which could have implications for user acceptability and provider willingness to offer the DPP. For both COC and oral PrEP, the provision of information on side effects and how to manage them improves outcomes and continued use ( 46 , 57 , 58 ). Counseling users to understand potential changes to bleeding patterns is key to user satisfaction and continuation with other FP methods ( 59 , 60 ), and by extension, is expected to be critical to effective use of the DPP.…”

Mobility and HIV care engagement: a research agenda

“…The magnitude of mobility's effects ranges widely—in part because definitions of mobility are so varied—from a 47% reduction in viral suppression to a six‐fold reduction in 1‐year retention. Mobile people are also less likely to be retained in pre‐exposure prophylaxis (PrEP) programmes [ 41 , 42 ]. Several qualitative studies from diverse settings, including West, East and Southern Africa, demonstrate how mobility can trigger a chain of events leading to treatment interruption [ 13 , 43 , 44 , 45 , 46 , 47 ].…”

Barriers to the uptake of oral pre-exposure prophylaxis among young key populations in Nigeria

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