Uptake and retention of catechins by Caco‐2 human intestinal cells is modulated by tea formulation following simulated digestion

Green, Rodney J.; Murphy, Angus S.; Ferruzzi, Mário G.

doi:10.1096/fasebj.21.5.a730-b

Cited by 3 publications

(3 citation statements)

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“…Recently, Green et al described that GT combined with citrus juice enhances the in vitro digestive recovery of TCAT and increases uptake efficiency in Caco-2 cells . This phenomenon could not be explained by the ascorbic acid level, indicating that other factors from juice may be responsible.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, Green et al 28 described that GT combined with citrus juice enhances the in vitro digestive recovery of TCAT and increases uptake efficiency in Caco-2 cells. 39 This phenomenon could not be explained by the ascorbic acid level, indicating that other factors from juice may be responsible. From the same group Peters et al 40 described that a formulation of GT with sucrose (without milk) modestly but significantly improved overall catechin digestive recovery, which supports our findings.…”

Section: Effect Of Milk Amount and Type And Sugar On Catechinmentioning

confidence: 96%

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Effect of Milk and Brewing Method on Black Tea Catechin Bioaccessibility

Burg-Koorevaar

Miret

Duchateau

2011

J. Agric. Food Chem.

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The aim of this study was to investigate whether milk reduces the bioaccessibility of tea catechins, which would compromise tea beneficial effects ascribed to polyphenols. Adding milk to black tea has been shown to lead to polyphenol-protein complexes. So far, data on the intestinal stability of polyphenol-protein complexes are scarce. English black tea (0.93 ± 0.06 mol/L total catechins) and Indian black tea (1.83 ± 0.08 mol/L catechins) were prepared with skimmed or full-fat milk and subjected to simulated gastric, small intestinal, and brush border digestion. Adding milk (5.6-40%) to tea results in a decrease of total catechin (TCAT) recovery. However, the bioaccessibilities of TCAT of tea with milk versus tea controls were comparable (p > 0.05). The type of milk did not influence TCAT recovery during all digestive stages (p > 0.05). Polyphenol-protein complexes are degraded during digestion. It is very unlikely that consumption of tea with or without milk will result in differences in catechin plasma concentration.

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Section: Resultsmentioning

confidence: 99%

Section: Effect Of Milk Amount and Type And Sugar On Catechinmentioning

confidence: 96%

Effect of Milk and Brewing Method on Black Tea Catechin Bioaccessibility

Burg-Koorevaar

Miret

Duchateau

2011

J. Agric. Food Chem.

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“…A variety of factors inhibit the bioavailability of EGCG including internal factors such as EGCG sensitivity to digestive tract conditions, poor intestinal transport, and rapid metabolism and clearance; and external factors such as effects of intake, food matrix, nutritional status, etc. [28,29]. Synergistic or restrictive effects also occur among various factors.…”

Section: Egcgmentioning

confidence: 99%

Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors

Liu

et al. 2019

Molecules

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Due to changes in the dietary structure of individuals, the incidence of digestive tract tumors has increased significantly in recent years, causing a serious threat to the life and health of patients. This has in turn led to an increase in cancer prevention research. Many studies have shown that epigallocatechin-3-gallate (EGCG), an active ingredient in green tea, is in direct contact with the digestive tract upon ingestion, which allows it to elicit a significant antagonizing effect on digestive tract tumors. The main results of EGCG treatment include the prevention of tumor development in the digestive tract and the induction of cell cycle arrest and apoptosis. EGCG can be orally administered, is safe, and combats other resistances. The synergistic use of cancer drugs can promote the efficacy and reduce the anti-allergic properties of drugs, and is thus, favored in medical research. EGCG, however, currently possesses several shortcomings such as poor stability and low bioavailability, and its clinical application prospects need further development. In this paper, we have systematically summarized the research progress on the ability of EGCG to antagonize the activity and mechanism of action of digestive tract tumors, to achieve prevention, alleviation, delay, and even treat human gastrointestinal tract tumors via exogenous dietary EGCG supplementation or the development of new drugs containing EGCG.

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Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea

Peters

Green

Janle

et al. 2010

Food Research International

158

117

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In order to investigate the impact of common food ingredients on catechin absorption, green tea (GT) extract (50 mg) was formulated plain, with sucrose (GT+S), with ascorbic acid (GT+AA) and with sucrose and ascorbic acid (GT+S+AA). Bioavailability and bioaccessibility were assessed in Sprague Dawley rats and an in vitro digestion/Caco-2 cell model respectively. Absorption of epigallocatechin (EGC) and epigallocatechin gallate (EGCG) was significantly (P<0.05) enhanced in GT+S+AA formulations (AUC0-6h= 3237.0 and 181.8 pmol*h/L plasma respectively) relative to GT control (AUC0-6h = 1304.1 and 61.0 pmol*h/L plasma respectively). In vitro digestive recovery was higher for EGC and epicatechin (EC) (∼51-53%) relative to EGCG and epicatechin gallate (ECG) (< 20%) and was modestly enhanced in GT+S and GT+S+AA formulations. Accumulation of EGC, EGCG and ECG by Caco-2 cells was significantly (P<0.05) higher from GT+S+AA compared to other formulations while retention of catechins was enhanced in presence of ascorbic acid. These data suggest that formulation with sucrose and ascorbic acid may improve catechin bioavailability by enhancing bioaccessibility and intestinal uptake from tea.

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Uptake and retention of catechins by Caco‐2 human intestinal cells is modulated by tea formulation following simulated digestion

Cited by 3 publications

References 0 publications

Effect of Milk and Brewing Method on Black Tea Catechin Bioaccessibility

Effect of Milk and Brewing Method on Black Tea Catechin Bioaccessibility

Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors

Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea

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