Uptake and retention of cadmium-109 in the pituitary, the adrenals and the thyroid of the laboratory rat

Kollmer, W. E.

doi:10.1016/0020-708x(80)90016-2

Cited by 10 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been recognized to alter prolactin secretion, by modifying the lactotroph cell activity in the pituitary Data were presented as mean ± SEM 1) a P < 0.05, aa P < 0.01 and aaa P < 0.001 vs. NC 2) bb P < 0.01 and bbb P < 0.001 vs. CD 3) c P < 0.05 and ccc P < 0.001 vs. TH 4) dd P < 0.01 and ddd P < 0.001 vs. THC gland, resulting in biochemical, genomic, and morphological changes [56]. Moreover, Cd is readily absorbed and accumulated in the pituitary gland of rats [60]. This could be attributed to the alteration in the normal function of HPA.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats

Ruslee

Zaid

Bakrin

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: To investigate the protective effects of Tualang honey against the toxicity effects induced by cadmium (Cd) on the ovary. Methods: A total of 32 female Sprague Dawley rats were taken and randomly divided into four groups (n = 8). Throughout the experimental period of 6 weeks, negative control-NC (vehicle deionized water), positive control-CD (Cd at 5 mg/kg), Tualang honey followed by Cd exposure-TH (Tualang honey at 200 mg/kg and Cd at 5 mg/kg) and Tualang honey control-THC (Tualang honey at 200 mg/kg) groups, were administered orally on a daily basis. Results: Rats exposed to Cd were significantly higher in ovarian weight, number of antral and atretic follicles as compared to the NC group. The disruptive effects of Cd on ovarian follicles were associated with a disruption in gonadotropin hormones and decreases in follicular stimulating hormone (FSH) and luteinizing hormone (LH). Moreover, a significant formation of oxidative stress in ovarian Cd-exposed rats has been proven by increasing the level of lipid peroxidation products (malondialdehyde) and decreasing the levels of enzymatic antioxidant (catalase). Interestingly, a daily supplementation of high antioxidant agents such as Tualang honey in these animals, caused significant improvements in the histological changes. Additionally, less atretic follicles were observed, restoring the normal level of LH and FSH (P < 0.001), and normalizing the ovarian malondialdehyde (P < 0.05) and catalase levels in comparison with CD group (P < 0.05). Conclusions: Tualang honey has protective effects against Cd-induced ovarian toxicity by reducing morphological abnormalities, restoring the normal levels of gonadotropin hormones and stabilizing equilibrium levels of lipid peroxidation and antioxidant enzyme in ovaries of rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats

Ruslee

Zaid

Bakrin

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

show abstract

“…Cadmium accumulates in mitochondria of thyroid follicular epithelial cells, this may distract the oxidative phosphorylation of mitochondria with subsequent loss of energy supply which inhibits thyroid hormone synthesis and release (26). The adrenal glands are found to have the capacity to accumulate cadmium more than other endocrine gland (27). Many previous support the idea that the adrenal gland is highly susceptible to cadmium compare to other endocrine glands (28).…”

Section: Discussionmentioning

confidence: 99%

Effects of cadmium chloride on some endocrine glands (thyroid and adrenal) in male rats (Rattus norvegicus)

Derawi¹

2019

IJVS

View full text Add to dashboard Cite

This study was designed to evaluate the cytotoxic effects of cadmium chloride (CdCl 2 ) on thyroid and adrenal gland of male rats (Rattus norvegicus). Thirty six male rats were used and randomly into three groups each of 12 rats, the first group(G1) kept as at control. The 2nd and 3rd groups (G2 and G3) were administrated orally cdcl 2 at doses of 15 and 20 mg/kg.B.W. respectively for 6 weeks. After the treatment period, the rats were sacrificed, then thyroid and adrenal glands were removed and processed for light microscope. Light microscopic examination of thyroid gland with (15mg/kg.B.W.) showed increase in the size of follicles, some of these follicles appeared empty from any colloidal substance and heavily infiltrated by inflammatory cells, with depletion of parafollicular cells. Vaculated follicles may be clear in other sections, and showed congested blood vessels, vascularized stroma, hyperplasia of thyrocyte in rats treated with 20 mg/kg.B.w. Results also noted changes in different regions of adrenal gland related to rats exposure tocdcl 2 with 15 mg/kg.B.W., these includes cellular debris, necrosis of cortical cells, amorphous material in the zona fasciculate and focal necrosis in zona granulosa with disruption of normal structure and replaced by necrotic cells and inflammatory cells, also obvious adipocytes infiltration which appeared clear in medulla. Most changes occurred within the adrenal cortex and appeared more severity than that in the medulla region. Hypereosinophilia, pyknotic nuclei, congested blood vessels, hemorrhage, degeneration and inflammation also seen in both regions (cortex and medulla) of adrenal gland from rat exposed to cdcl 2 at 20 mg/kg.B.W.

show abstract

“…6–8 Cadmium mimics the function of steroid hormones and its potential role in the development of hormone-dependent cancers is widely discussed. 9 Studies carried out on rats also prove that Cd 2+ is absorbed and retained in the pituitary gland, 10,11 leading to a decrease in content of luteinizing hormone and alteration of gland functionality. 7,8,12 In the mouse Mus platythrix , cadmium induces hypertrophy and hyperplasia of pituitary gonadotrophs.…”

Section: Introductionmentioning

confidence: 99%

Cadmium induces changes on ACTH and PRL cells in Podarcis sicula Lizard pituitary gland

2010

View full text Add to dashboard Cite

We analyzed the effect of cadmium on corticotropic (ACTH) and prolactin (PRL) cells in the pituitary gland of the Podarcis sicula (P. sicula) lizard under chronic exposure to this metal. Adult lizards were given CdCl2 in drinking water at the dose of 10 µg/10 g body mass for 120 days. Light microscopy was performed after histological and immunohistochemical staining, and the effects were followed at regular time intervals up to 120 days post-treatment. We detected substantial variations in the general morphology of the pituitary: unlike the control lizards in which the gland appeared compact, the treated lizards showed a glandular tissue with dilated spaces that were more extensive at 90 and 120 days. PRL and ACTH cells showed an increase in occurrence and immunostaining intensity in treated lizards in comparison with the same cells of control animals. This cellular increase peaked for PRL at 30 days in the rostral, medial and also caudal pars distalis of the gland. ACTH cells appeared to increase markedly after 60 days of treatment in both the pars distalis and the pars intermedia. Again, at 60 days small, isolated ACTH cells were also found in the caudal pars distalis in which these cells were generally absent. However, at 120 days both these cellular types showed an occurrence, distribution and morphology similar to those observed in the control lizards. In lizards, protracted oral exposure to cadmium evidently involves an alteration of the normal morphology of the gland and an inhibitory effect of ACTH and PRL cells, since they increase in occurrence and immunostaining. Yet in time the inhibitory effect of cadmium on ACTH and PRL cells falls back and their occurrence appears similar to that of the control lizard.

show abstract

Uptake and retention of cadmium-109 in the pituitary, the adrenals and the thyroid of the laboratory rat

Cited by 10 publications

References 8 publications

Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats

Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats

Effects of cadmium chloride on some endocrine glands (thyroid and adrenal) in male rats (Rattus norvegicus)

Cadmium induces changes on ACTH and PRL cells in Podarcis sicula Lizard pituitary gland

Contact Info

Product

Resources

About