Uptake and metabolism of clarithromycin and sulfadiazine in lettuce

Tian, Run Xia; Zhang, Rong; Uddin, Misbah; Qiao, Xianliang; Chen, Jingwen; Gu, Ge‐Ge

doi:10.1016/j.envpol.2019.02.009

Cited by 68 publications

(41 citation statements)

References 51 publications

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“…Differently, valsartan acid, which was also identified with of level 1 of confidence due to the availability of an analytical standard was found in TWW (111.17 ± ng/L) and in soil (1.7 ± ng/L) in accordance with its high environmental persistency but not in lettuce leave excluding valsartan acid plant uptake. None of the known metabolites of clarithromycin was detected in this study, even though clarithromycin was found to be extensively and quickly metabolized in lettuce (Tian et al, 2019) with a proportion of metabolites, which was estimated to account for more than 70% of the initial clarithromycin concentration. This finding might result from very low formation rates of clarithromycin metabolites, thus escaping from analytical determination.…”

Section: Fate Of Contaminants In Soil: Chiral Analysis Of Metoprolol and Climbazolecontrasting

confidence: 55%

“…1 mg/L) to elucidate metabolic pathways and under hydroponic conditions to discriminate between soil-generated TPs and plant-generated metabolites and because plants absorb higher levels of organic contaminants in hydroponic conditions than in soil experiments. For instance, such experiments were conducted to elucidate TPs of clarithromycin (Tian et al, 2019), carbamazepine (Martinez-Piernas et al, 2019) and ofloxacin (Tadic et al, 2020) in lettuce crop.…”

Section: Fate Of Contaminants In Soil: Chiral Analysis Of Metoprolol and Climbazolementioning

confidence: 99%

See 1 more Smart Citation

Impact of long-term irrigation with municipal reclaimed wastewater on the uptake and degradation of organic contaminants in lettuce and leek

Manasfi

Brienza

Ait-Mouheb

et al. 2021

Science of The Total Environment

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Fate Of Contaminants In Soil: Chiral Analysis Of Metoprolol and Climbazolecontrasting

confidence: 55%

Section: Fate Of Contaminants In Soil: Chiral Analysis Of Metoprolol and Climbazolementioning

confidence: 99%

Impact of long-term irrigation with municipal reclaimed wastewater on the uptake and degradation of organic contaminants in lettuce and leek

Manasfi

Brienza

Ait-Mouheb

et al. 2021

Science of The Total Environment

View full text Add to dashboard Cite

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“…When investigating the uptake and metabolism of clarithromycin and sulfadiazine in lettuce, Tian et al (2019) highlighted the importance of studying antibiotic metabolites alongside parent compounds in accurately defining risk associated with crops exposed to antibiotics. Eight metabolites of clarithromycin and two metabolites of sulfadiazine were identified both in the leaves and roots of hydroponically grown lettuce.…”

Section: Antibiotics In Agroecosystemsmentioning

confidence: 99%

Detection, occurrence, and fate of emerging contaminants in agricultural environments (2020)

Snow

Cassada

Biswas

et al. 2020

Water Environment Research

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A review of 79 papers published in 2019 is presented. The topics ranged from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, antibiotics, anthelmintics, and engineered nanomaterials in agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Antibiotics in Agroecosystems, Pharmaceutical Fate and Occurrence, Anthelmintics and Engineered Nanomaterials.

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“…In phase II, xenobiotics or their activated phase I metabolites undergo conjugation with endogenous plant compounds [14]. Conjugation of xenobiotics in plants may happen with various substituents, such as acetyl, methyl, and sulfate groups, glucuronic acid, cladinose, glucose, glutathione, glucopyranosyloxy and malonyl groups, pterin, methyl salicylate, leucyl, glutamic acid, and glutamine molecules, amongst others [15][16][17][18][19]. As a result, phase II might yield "endless" conjugation possibilities in plants as a detoxification mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, only a few studies on the metabolization of sulfonamides (i.e. sulfamethoxazole, sulfadiazine, and sulfamethazine) [15][16][17]30], clarithromycin [16], and ofloxacin [31] in plants have been reported. For example, clarithromycin follows four major metabolic pathways in lettuce, including cladinose hydrolysis, demethylation, methylation, and oxidation [16].…”

Section: Introductionmentioning

confidence: 99%

Systematic identification of trimethoprim metabolites in lettuce

et al. 2022

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Antibiotics are some of the most widely used drugs. Their release in the environment is of great concern since their consumption is a major factor for antibiotic resistance, one of the most important threats to human health. Their occurrence and fate in agricultural systems have been extensively investigated in recent years. Yet whilst their biotic and abiotic degradation pathways have been thoroughly researched, their biotransformation pathways in plants are less understood, such as in case of trimethoprim. Although trimethoprim has been reported in the environment, its fate in higher plants still remains unknown. A bench-scale experiment was performed and 30 trimethoprim metabolites were identified in lettuce (Lactuca sativa L.), of which 5 belong to phase I and 25 to phase II. Data mining yielded a list of 1018 ions as possible metabolite candidates, which was filtered to a final list of 87 candidates. Molecular structures were assigned for 19 compounds, including 14 TMP metabolites reported for the first time. Alongside well-known biotransformation pathways in plants, additional novel pathways were suggested, namely, conjugation with sesquiterpene lactones, and abscisic acid as a part of phase II of plant metabolism. The results obtained offer insight into the variety of phase II conjugates and may serve as a guideline for studying the metabolization of other chemicals that share a similar molecular structure or functional groups with trimethoprim. Finally, the toxicity and potential contribution of the identified metabolites to the selective pressure on antibiotic resistance genes and bacterial communities via residual antimicrobial activity were evaluated.

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Uptake and metabolism of clarithromycin and sulfadiazine in lettuce

Cited by 68 publications

References 51 publications

Impact of long-term irrigation with municipal reclaimed wastewater on the uptake and degradation of organic contaminants in lettuce and leek

Impact of long-term irrigation with municipal reclaimed wastewater on the uptake and degradation of organic contaminants in lettuce and leek

Detection, occurrence, and fate of emerging contaminants in agricultural environments (2020)

Systematic identification of trimethoprim metabolites in lettuce

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