Uptake and Gene Expression of Naked Plasmid DNA in Cultured Brain Microvessel Endothelial Cells

Nakamura, Masaru; Davila-Zavala, Pablo; Tokuda, Hideaki; Takakura, Yoshinobu; Hashida, Mitsuru

doi:10.1006/bbrc.1998.8334

Cited by 36 publications

(15 citation statements)

References 22 publications

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“…Gel particles having a close to neutral surface charge have been demonstrated to have longer circulation times [216,217]. However, the most important feature of nanogels, their stimuli-responsive behavior, is usually attributable to the charged groups incorporated into network.…”

Section: Obstacles To Clinical Translation and Strategies Being Dementioning

confidence: 99%

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

Soni

Desale

Bronich³

2016

Journal of Controlled Release

492

348

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Section: Obstacles To Clinical Translation and Strategies Being Dementioning

confidence: 99%

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

Soni

Desale

Bronich³

2016

Journal of Controlled Release

492

348

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show abstract

“…The class of scavenger receptors involved in uptake of DNA is not well studied, although studies performed on LSEC [170] and brain microvessel endothelial cells [217], show uptake of pDNA via a specific mechanism resembling scavenger receptors. However, scavenger receptor class A is unlikely to be responsible for the uptake of pDNA, as shown in scavenger receptor class A knockout mice [171].…”

Section: Scavenger Endothelial Cellsmentioning

confidence: 99%

What happens to the DNA vaccine in fish? A review of current knowledge

Tonheim

Bøgwald

Dalmo

2008

Fish & Shellfish Immunology

139

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“…The ex vivo method of naked DNA delivery has been used successfully for the introduction of DNA into endothelial and smooth muscle cells[106107], its reliance on the culture of harvested cells renders it unsuitable for many cell types. In vivo delivery of naked DNA was first described in 1990[108].…”

Section: Gene Transfer Technologiesmentioning

confidence: 99%

DNA as therapeutics; an update

Saraswat

Soni²,

Bhandari

et al. 2009

Indian J Pharm Sci

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Human gene therapy is the introduction of new genetic material into the cells of an individual with the intention of producing a therapeutic benefit for the patient. Deoxyribonucleic acid and ribonucleic acid are used in gene therapy. Over time and with proper oversight, human gene therapy might become an effective weapon in modern medicine's arsenal to help fight diseases such as cancer, acquired immunodeficiency syndrome, diabetes, high blood pressure, coronary heart disease, peripheral vascular disease, neurodegenerative diseases, cystic fibrosis, hemophilia and other genetic disorders. Gene therapy trials in humans are of two types, somatic and germ line gene therapy. There are many ethical, social, and commercial issues raised by the prospects of treating patients whose consent is impossible to obtain. This review summarizes deoxyribonucleic acid-based therapeutics and gene transfer technologies for the diseases that are known to be genetic in origin. Deoxyribonucleic acid-based therapeutics includes plasmids, oligonucleotides for antisense and antigene applications, deoxyribonucleic acid aptamers and deoxyribonucleic acidzymes. This review also includes current status of gene therapy and recent developments in gene therapy research.

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Uptake and Gene Expression of Naked Plasmid DNA in Cultured Brain Microvessel Endothelial Cells

Cited by 36 publications

References 22 publications

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

What happens to the DNA vaccine in fish? A review of current knowledge

DNA as therapeutics; an update

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