Uptake and Dissolution of Particulate Iodipamide Ethyl Ester in the Spleen A Morphologic Study

Lauteala, Lauri; Kormano, Martti; Violante, Michael R.

doi:10.1097/00004424-198710000-00010

Cited by 5 publications

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“…The PMNs exhibited local degeneration similar to that seen in the phagocytes of the liver and spleen (2,4). Aggregated leukocytes can release proteolytic entzymes, but actually no cell aggregates were seen; the PMNs were jammed in the smallest capillaries so that a single cell filled the lumen of the capillary.…”

Section: Lungsmentioning

confidence: 79%

Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat

Lauteala

Kormano

Violante

1988

APMIS

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Lauteala, L., Kormano, M. & Violante, M. R. Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat. A morphological study. APMIS 96: 660-666, 1988.Particulate iodipamide ethyl ester, a new hepatolienographic x-ray contrast agent, was intravenously injected into rats. Lung and kidney biopsies taken at various intervals after the injection were examined by light and electron microscopy. IDE particles could be found in the lung capillaries phagocytized by polymorphonuclear neutrophils (PMNs). There were also free particles in the alveolar capillaries in the samples taken 5 min to 4 hours after the injection. No aggregates or emboli were seen. Two days or more after the injection no intra-and extracellular particles were present. The PMNs underwent transient local hydropic degeneration; the lung cells were morphologically intact. In the kidneys, the particles first appeared in both cortical and medullary capillaries. No emboli were observed. The kidney cells did not ingest IDE, but polymorphonuclear neutrophils (PMNs) with ingested IDE were often seen loosely attached to the glomerular capillary walls. In addition, free particles were evident in the capillaries in the samples taken up to 1 hour after injection. All particles in subsequent kidney samples were located in PMNs in the glomeruli. After three or more days the renal tissue was totally devoid of particulate IDE. No morphological evidence of kidney cell injury was observed.

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Section: Lungsmentioning

confidence: 79%