Uptake and delivery of antigens by mesenchymal stromal cells

Sánchez‐Abarca, Luis Ignacio; Álvarez-Laderas, Isabel; Díez-Campelo, Maria; Caballero‐Velázquez, Teresa; Herrero, Carmen; Muntión, Sandra; Calderón, Cristina; García-Guerrero, Estefanía; Sánchez‐Guijo, Fermín; Cañizo, Consuelo del; Miguel, Jesús F. San; Pérez-Simón, Josè Antonio

doi:10.1016/j.jcyt.2013.01.216

Cited by 15 publications

(18 citation statements)

References 31 publications

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“…Relative to fibroblasts and other stromal cell types discussed herein, MSCs are rare 58 . Their primary functions are to regulate the immune response and to promote tissue regeneration 44,59–62 . They are also the source of osteoblasts and chondrocytes in bones and joints, respectively.…”

Section: Components Of the Stromamentioning

confidence: 99%

Targeting the tumour stroma to improve cancer therapy

2018

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Cancers are not merely composed of cancer cells alone and, instead, are complex ‘ecosystems’ comprising many different cell types and noncellular factors. The tumour stroma is a critical component of the tumour microenvironment, where it has crucial roles in tumour initiation, progression, and metastasis. Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote resistance of cancer cells to such therapies, eventually resulting in fatal disease. Therefore, novel treatment strategies should combine anticancer and antistroma agents. Herein, we provide an overview of the advances in understanding the complex cancer cell–tumour stroma interactions, and discuss how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes.

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Section: Components Of the Stromamentioning

confidence: 99%

Targeting the tumour stroma to improve cancer therapy

2018

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“…MSCs also influence T-cell behavior, supporting T-cell survival in a quiescent state, when they are subjected to stress conditions, which could lead to apoptosis [25]. In addition, antigen-presenting cell (APC) property and proinflammatory activity are also shared by MSCs [133, 134]. Furthermore, there are evidences that MSCs support tumoral progression through mechanisms that include signaling networks with other cells of tumor microenvironment [135, 136], tumoral angiogenesis [137–139], cellular alteration by hybrid/chimeric cell generation [140, 141], cancer growth by promoting the proliferation and migration of MSCs themselves [142], and metastasis induction [143–145].…”

Section: Mesenchymal Stromal Cells “Activation”mentioning

confidence: 99%

Mechanisms of T-Cell Immunosuppression by Mesenchymal Stromal Cells: What Do We Know So Far?

Haddad

Saldanha-Araújo

2014

BioMed Research International

147

123

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Mesenchymal stromal cells (MSCs) are multipotent cells, which can give rise to several cell types including osteoblasts, adipocytes, and chondroblasts. These cells can be found in a variety of adult and fetal tissues, such as bone marrow, adipose tissue, cord blood, and placenta. In recent years, the biological properties of MSCs have attracted the attention of researchers worldwide due to their potential application for treating a series of clinical situations. Among these properties, special attention should be given to the immunoregulatory potential of those cells. MSCs are able to act on all cells of the immune system, which includes the capacity to inhibit the proliferation and function of T-cells. This feature renders them natural candidates to treat several diseases in which cellular immune response is exacerbated. In this review, we outline the main mechanisms by which MSCs immunosuppress T-cell response, focusing on cell-cell contact, secretion of soluble factors, and regulatory T-cell generation. The influence of surface markers in the immunosuppression process and features of MSCs isolated from different sources are also discussed. Finally, the influences of toll-like receptors and cytokines on the inflammatory microenvironment are highlighted regarding the activation of MSCs to exert their immunoregulatory function.

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“…Finally, MSCs were suggested to behave in some cases as antigen-presenting cells and/or to trigger immune responses [60,61]. Interestingly, Sánchez-Abarca et al [60] showed that P3 hBM-MSCs are capable of capturing and releasing antigens, although at much lower levels than DCs, with possible involvement of TLRs.…”

Section: Immunomodulatory Propertiesmentioning

confidence: 99%

“…Interestingly, Sánchez-Abarca et al [60] showed that P3 hBM-MSCs are capable of capturing and releasing antigens, although at much lower levels than DCs, with possible involvement of TLRs. Taking into consideration that preclinical studies are not always homogeneous and/or unequivocal regarding MSCs immunomodulatory and/or their immunogenicity properties and in order to be able to build knowledge on consistent and solid data, the MSC Committee of the International Society for Cellular Therapy published a "working proposal for a standardized approach based on a critical view of literature data" [62].…”

Section: Immunomodulatory Propertiesmentioning

confidence: 99%

Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives

Fiore

Mazzolini

Aquino

2015

Stem Cell Rev and Rep

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Mesenchymal stem/stromal cells (MSCs) are progenitors which share plastic-adherence capacity and cell surface markers but have different properties according to their cell and tissue sources and to culture conditions applied. Many recent publications suggest that MSCs can differentiate into hepatic-like cells, which can be a consequence of either a positive selection of rare in vivo pluripotent cells or of the original plasticity of some cells contributing to MSC cultures. A possible role of MSCs in hereditary transmission of obesity and/or diabetes as well as properties of MSCs regarding immunomodulation, cell fusion and exosome release capacities are discussed according to recent literature. Limitations in methods used to track MSCs in vivo especially in the context of liver cirrhosis are addressed as well as strategies explored to enhance their migratory, survival and proliferation properties, which are known to be relevant for their future clinical use. Current knowledge regarding mechanisms involved in liver cirrhosis amelioration mediated by naïve and genetically modified MSCs as well as the effects of applying preconditioning and combined strategies to improve their therapeutic effects are evaluated. Finally, first reports of GMP guidelines and biosafety issues in MSCs applications are discussed.

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Uptake and delivery of antigens by mesenchymal stromal cells

Cited by 15 publications

References 31 publications

Targeting the tumour stroma to improve cancer therapy

Targeting the tumour stroma to improve cancer therapy

Mechanisms of T-Cell Immunosuppression by Mesenchymal Stromal Cells: What Do We Know So Far?

Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives

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