Uptake and bioaccumulation of titanium- and silver-nanoparticles in aquatic ecosystems

Nam, Doo Hyun; Lee, Byoungcheun; Eom, Ig-Chun; Kim, Pilje; Yeo, Min‐Kyeong

doi:10.1007/s13273-014-0002-2

Cited by 51 publications

(26 citation statements)

References 54 publications

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“…Although many reviews have been published that focus on, for example,1 )environmental realism of test conditions, [33] 2) modeling approaches, [34] 3) effects of organic matter on toxicity, [35] and 4) ecotoxicological effects of various ENPs, [36][37][38][39] there still seems to be al ack of reviews assessing nanoparticle effects in terms of test setups and effects observed. Handy et al [40] and Petersen et al [41] reviewed and presented aw ide range of practical considerations to be considered when conducting ecotoxicological tests with ENPs.H owever,t he practical considerations and the confounding factors of ENPs in test setups have to,o ur knowledge,n ot been reviewed in regard to assessing the effects of the nanoparticles.Isolating the nanoparticle effect caused by the novel intrinsic properties of the ENPs because of their size is not possible from the currently published reviews.Throughout this Review the implications of the properties of ENPs and their related behavior in test media before,d uring,a nd after ecotoxicity testing will be evaluated with aspecific focus on the base set of aquatic organisms (fish, crustaceans,a nd algae) used for classification, labeling,a nd concentrationresponse assessment to determine the nanoparticle effect.…”

Section: Introductionmentioning

confidence: 99%

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

et al. 2016

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The number of products on the market containing engineered nanoparticles (ENPs) has increased significantly, and concerns have been raised regarding their ecotoxicological effects. Environmental safety assessments as well as relevant and reliable ecotoxicological data are required for the safe and sustainable use of ENPs. Although the number of publications on the ecotoxicological effects and uptake of ENPs is rapidly expanding, the applicability of the reported data for hazard assessment is questionable. A major knowledge gap is whether nanoparticle effects occur when test organisms are exposed to ENPs in aquatic test systems. Filling this gap is not straightforward, because of the broad range of ENPs and the different behavior of ENPs compared to “ordinary” (dissolved) chemicals in the ecotoxicity test systems. The risk of generating false negatives, and false positives, in the currently used tests is high, and in most cases difficult to assess. This Review outlines some of the pitfalls in the aquatic toxicity testing of ENPs which may lead to misinterpretation of test results. Response types are also proposed to reveal potential nanoparticle effects in the aquatic test organisms.

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Section: Introductionmentioning

confidence: 99%

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

et al. 2016

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“…From 1916 to 2011, an estimated total of 165 050 000 metric tonnes of TiO 2 pigment were produced worldwide (bulk form and nanoform combined), with a current annual estimated production of more than 6 million tonnes/yr . Reviews of nano‐TiO 2 toxicology are available across various evolutionary groups of species , often summarizing half maximal effective concentration (EC50), half maximal inhibitory concentration (IC50), and median lethal concentration (LC50) values. Nano‐TiO 2 is also photoactive and produces reactive oxygen species (ROS) on illumination .…”

Section: Introductionmentioning

confidence: 99%

Review of titanium dioxide nanoparticle phototoxicity: Developing a phototoxicity ratio to correct the endpoint values of toxicity tests

Jovanović¹

2015

Enviro Toxic and Chemistry

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Titanium dioxide nanoparticles are photoactive and produce reactive oxygen species under natural sunlight. Reactive oxygen species can be detrimental to many organisms, causing oxidative damage, cell injury, and death. Most studies investigating TiO2 nanoparticle toxicity did not consider photoactivation and performed tests either in dark conditions or under artificial lighting that did not simulate natural irradiation. The present study summarizes the literature and derives a phototoxicity ratio between the results of nano‐titanium dioxide (nano‐TiO2) experiments conducted in the absence of sunlight and those conducted under solar or simulated solar radiation (SSR) for aquatic species. Therefore, the phototoxicity ratio can be used to correct endpoints of the toxicity tests with nano‐TiO2 that were performed in absence of sunlight. Such corrections also may be important for regulators and risk assessors when reviewing previously published data. A significant difference was observed between the phototoxicity ratios of 2 distinct groups: aquatic species belonging to order Cladocera, and all other aquatic species. Order Cladocera appeared very sensitive and prone to nano‐TiO2 phototoxicity. On average nano‐TiO2 was 20 times more toxic to non‐Cladocera and 1867 times more toxic to Cladocera (median values 3.3 and 24.7, respectively) after illumination. Both median value and 75% quartile of the phototoxicity ratio are chosen as the most practical values for the correction of endpoints of nano‐TiO2 toxicity tests that were performed in dark conditions, or in the absence of sunlight. Environ Toxicol Chem 2015;34:1070–1077. © 2015 The Author. Published by SETAC.

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“…Exposures of fish to AgNPs can lead to accumulation of total Ag in tissues, such as the liver and intestines, and the Ag can accumulate in organelles, including the nucleus and mitochondria . In the present study, fish from the AgNP treatments accumulated approximately 10‐fold less total Ag in tissues than fish from the Ag + treatments.…”

Section: Discussionmentioning

confidence: 43%

Biomarkers of exposure to nanosilver and silver accumulation in yellow perch (Perca flavescens)

Martin

Colson

Langlois

et al. 2016

Enviro Toxic and Chemistry

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There is a risk of exposure of aquatic organisms to silver nanoparticles (AgNPs) from discharges of municipal and industrial wastewater. In the present study, yellow perch (Perca flavescens) were exposed to environmentally relevant concentrations (1 mg/L and 100 mg/L) of AgNPs and silver ions (Ag ) in static-renewal experiments conducted over 96 h and 10 d. The greatest accumulation of total Ag occurred in the liver of P. flavescens, and there was >10-fold more accumulation in the treatments with Ag relative to the AgNP treatments. Residues of total Ag increased with concentration and duration of exposure in liver, gill, and muscle. Both exposures caused a 2-fold induction of gene expression for metallothionein (mt) in liver tissue after 96 h of exposure and reductions in levels of oxidized glutathione (GSSG) in liver after 10 d of exposure. Both AgNPs and Ag decreased the expression of heat-shock proteins (hsp70). Exposure to the high concentration of AgNPs for 10 d significantly increased lipid peroxidation in gill tissue, as indicated by the thiobarbituric acid reactive substances (TBARS) assay. There was a negative correlation between mean levels of GSSG and TBARS for both gill and liver tissue when data for all treatments were combined. It is significant that these biological responses were observed in P. flavescens exposed to AgNPs, even though accumulation of total Ag was at least 10-fold lower relative to the treatments with Ag . Environ Toxicol Chem 2017;36:1211-1220. © 2016 SETAC.

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Uptake and bioaccumulation of titanium- and silver-nanoparticles in aquatic ecosystems

Cited by 51 publications

References 54 publications

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects

Review of titanium dioxide nanoparticle phototoxicity: Developing a phototoxicity ratio to correct the endpoint values of toxicity tests

Biomarkers of exposure to nanosilver and silver accumulation in yellow perch (Perca flavescens)

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