Uptake and bioaccumulation of three widely prescribed pharmaceutically active compounds in tomato fruits and mediated effects on fruit quality attributes

Christou, Anastasis; Kyriacou, Marios C.; Georgiadou, Egli C.; Papamarkou, Rafail; Hapeshi, Evroula; Karaolia, Popi; Michael, Costas; Fotopoulos, Vasileios; Fatta‐Kassinos, Despo

doi:10.1016/j.scitotenv.2018.08.053

Cited by 43 publications

(32 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study by Winker et al (2010) documented lower concentrations of carbamazepine in ryegrass tissues when applied in a mixture with ibuprofen than when applied as a single compound solution. Christou et al (2019) showed that while the SUL concentration in tomato fruits was reduced when applied together with trimethoprim or diclofenac, trimethoprim followed the opposite trend. On the other hand, Kodešová et al (2019a) did not find statistical differences between the uptake of ATE, SUL, and CAR applied in single compound solutions or their mixture.…”

Section: Introductionmentioning

confidence: 99%

“…The water environment and soils can be also polluted by veterinary pharmaceuticals from animal urine or farm waste (e.g., Charuaud et al, 2019). Pharmaceuticals present in soils can be taken up by plants (e.g., Ahmed et al, 2015;Al-Farsi et al, 2017;Christou et al, 2019;Goldstein et al, 2014;Kodešová et al, 2019a, b;Li et al, 2018Li et al, , 2019aMalchi et al, 2014;Montemurro et al, 2017;Mordechay et al, 2018;Shenker et al, 2011;Winker et al, 2010;Wu et al, 2013). Some of the studies (e.g., Kodešová et al, 2019b;Malchi et al, 2014;Paltiel et al, 2016) indicated a potential human health treat, if contaminated plant tissues (mainly roots and leaves) are consumed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Uptake, translocation and transformation of three pharmaceuticals in green pea plants

Klement

Kodešová

Golovko

et al. 2020

Journal of Hydrology and Hydromechanics

View full text Add to dashboard Cite

Treated water from wastewater treatment plants that is increasingly used for irrigation may contain pharmaceuticals and, thus, contaminate soils. Therefore, this study focused on the impact of soil conditions on the root uptake of selected pharmaceuticals and their transformation in a chosen soil–plant system. Green pea plants were planted in 3 soils. Plants were initially irrigated with tap water. Next, they were irrigated for 20 days with a solution of either atenolol (ATE), sulfamethoxazole (SUL), carbamazepine (CAR), or all of these three compounds. The concentrations of pharmaceuticals and their metabolites [atenolol acid (AAC), N1-acetyl sulfamethoxazole (N1AS), N4-acetyl sulfamethoxazole (N4AS), carbamazepine 10,11-epoxide (EPC), 10,11-dihydrocarbamazepine (DHC), trans-10,11-dihydro-10,11-dihydroxy carbamazepine (RTC), and oxcarbazepine (OXC)] in soils and plant tissues were evaluated after harvest. The study confirmed high (CAR), moderate (ATE, AAC, SUL), and minor (N4AC) root uptake of the studied compounds by the green pea plants, nonrestricted transfer of the CAR species into the different plant tissues, and a very high efficiency in metabolizing CAR in the stems and leaves. The results showed neither a synergic nor competitive influence of the application of all compounds in the solution on their uptake by plants. The statistical analysis proved the negative relationships between the CAR sorption coefficients and the concentrations of CAR, EPC, and OXC in the roots (R = –0.916, –0.932, and –0.925, respectively) and stems (R = –0.837, –0.844, and –0.847, respectively).

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uptake, translocation and transformation of three pharmaceuticals in green pea plants

Klement

Kodešová

Golovko

et al. 2020

Journal of Hydrology and Hydromechanics

View full text Add to dashboard Cite

show abstract

“…The size of droplets determines the distance that the droplets will be transported through the air. As predicted by Stokes' Law, the smaller the droplet size, the further the droplets will be transported (Christou et al 2019a;Gupta and Madramootoo 2017;Kibuye et al 2019;Pepper and Gerba 2018). Sprinkler irrigation systems can be classified into two major types: (1) rotating head or revolving sprinkler system and (2) perforated pipe system, also referred to as "spray irrigation."…”

Section: Irrigation Systemsmentioning

confidence: 99%

“…Only few studies followed an experimental setup where real STP effluent was applied for irrigation of crops in field, representing actual farming practices. Moreover, even fewer studies have reported concentrations of the studied CoECs in both the growing medium (i.e., soil) and the edible tissues of the crops, thus allowing for the estimation of the bioconcentration factor (Christou et al 2017b(Christou et al , 2019aFranklin et al 2015;Goldstein et al 2014;Pan et al 2014;Picó et al 2019;Riemenschneider et al 2016). For example, Goldstein et al (2014) reported that the concentration of CoECs in cucumber and tomato leaves of crops grown in three different soils in pots was of similar order, whereas their concentration in the tomato fruit was much lower compared to that in the cucumber fruit.…”

Section: Extrinsic Properties Of Organic Coecsmentioning

confidence: 99%

Natural Purification Through Soils: Risks and Opportunities of Sewage Effluent Reuse in Sub-surface Irrigation

Narain-Ford

Bartholomeus

Dekker

et al. 2020

Reviews of Environmental Contamination and Toxicology

View full text Add to dashboard Cite

At global level there are several guidelines, i.e., non-mandatory recommendations, available concerning water reuse (Table 1). In 2006 the World Health Organization (WHO) published guidelines on the safe use of wastewater, intended as a tool for decision-makers and regulators to provide a consistent level of health protection in different settings. The guidelines can be adapted for implementation under specific environmental, sociocultural, and economic conditions at a national level (WHO 2006). The United States Environmental Protection Agency issued the last version of the "Guidelines for Water Reuse" (USEPA 2012). These guidelines include a wide range of reuse applications (e.g., agricultural irrigation and aquifer recharge) and apply similar approaches as described by the WHO (2006) and the Australian Government Initiative (2006) for controlling health and environmental risks. The most recent global guidelines for STP effluent reuse in agricultural irrigation were published in 2015 by the International Organization for Standardization (ISO 2015). These ISO guidelines include water quality requirements for CoECs. Remarkably, the State of California overtakes these global guidelines with specific regulations for CoECs (California Water Boards 2019). Consequently, these California water reuse regulations are being used as a global benchmark for the development of water reuse regulations worldwide. Noteworthy, California recently signed the Senate Bill No. 996 (Legislative Counsel Bureau 2018), which encourages communities to reuse STP effluent on-site. 2.2 Europe At European level the need to address management of water resources to prevent scarcity and droughts was acknowledged in the EU's Blueprint to safeguard Europe's water resources (Table 1). In this Blueprint the need to use STP effluent as an alternative water resource for irrigation purposes is re-emphasized (European Commission 2012). Six EU Member States

show abstract

“…Due to its properties, SMX dissolves in cell membranes and is released into the cytosol in plants (Goldstein, Shenker, & Chefetz, 2014). More recently, Christou et al (2019) has proved that tomatoes can uptake and accumulate SMX in hydroponic conditions, increasing their carbohydrate content. However, different results were obtained by Wu, Conkle, Ernst, and Gan (2014), who did not detect SMX in plant tissues, or in fields irrigated with treated wastewater.…”

Section: Sulfonamidesmentioning

confidence: 99%

Environmental impact and biological removal processes of pharmaceutically active compounds: The particular case of sulfonamides, anticonvulsants and steroid estrogens

Leal

Mesquita

Amaral

et al. 2019

Critical Reviews in Environmental Science and Technology

View full text Add to dashboard Cite

Pharmaceutically active compounds (PhACs) have recently received wide attention in the scientific community due to their extensive consumption for human health and consequent discharge to the environment. Release of PhACs into the environment, even in trace amounts, can cause serious environmental damage. This has become a major concern and their removal from water sources is a priority. Although a few PhACs are efficiently removed in wastewater treatment plants (WWTPs), others remain recalcitrant, and their release is causing damage. In this review, the current state of the art on the biological removal processes of sulfonamide sulfamethoxazole (SMX), the anticonvulsant carbamazepine (CBZ), and steroid estrogens 17b-estradiol (E2) and 17a-ethinylestradiol (EE2) are discussed, along with their environmental impact. Other systems beyond activated sludge, such as membrane bioreactors, enzymatic membrane reactors, fungi treatments and hybrid systems are also becoming of major interest and are being evaluated for the removal of these compounds. Future perspectives are addressed.

show abstract

Uptake and bioaccumulation of three widely prescribed pharmaceutically active compounds in tomato fruits and mediated effects on fruit quality attributes

Cited by 43 publications

References 67 publications

Uptake, translocation and transformation of three pharmaceuticals in green pea plants

Uptake, translocation and transformation of three pharmaceuticals in green pea plants

Natural Purification Through Soils: Risks and Opportunities of Sewage Effluent Reuse in Sub-surface Irrigation

Environmental impact and biological removal processes of pharmaceutically active compounds: The particular case of sulfonamides, anticonvulsants and steroid estrogens

Contact Info

Product

Resources

About