“…After the first report of PGs in an invertebrate organism, the gorgonian coral Plexaura homomalla (Weinheimer & Spraggins, 1969), evidence obtained using techniques such as mammalian smooth muscle bioassays, radioimmunoassays and labelled arachidonic acid (AA) incorporation experiments has led to the suggestion that prostanoids are present in, for example, the freshwater mussel Ligunia subrostrata (Saintsing et al, 1983), the freshwater snail Heliosoma durgi (Kunigelis & Saleuddin, 1986), the mussel Mytilus californianus (Morse et al, 1977) and several coelenterates (Morse et al, 1978). Specific PGA2 binding sites were detected in homogenates of gills, mantle, siphon, adductors, and upper and lower visceral masses from the marine bivalve Modiolus demissus (Freas & Grollman, 1981). However, the structures of the eicosanoids involved were elucidated completely in only a few cases, and usually evidence of eicosanoid participation was based on treatment of specimens with a single compound and observation of the response.…”