Accumulating evidence using data from individual centers, 1 as well as national registries, 2,3 substantiating the advantages of lung transplant for patients who experience irreversible lung damage due to COVID-19 infection, finds an essential supplement in the retrospective review by Tasoudis et al. 4 The study discerned that patients receiving lung transplants for COVID-19-related acute respiratory distress syndrome (ARDS) and pulmonary fibrosis in the US demonstrated comparable overall survival rates with those who exhibited other pretransplant pathologies.Previously, our team at Northwestern University, the Successful Clinical Response in Pneumonia Therapy (SCRIPT) study investigators, identified that SARS-CoV-2 elicits T-cell chemoattractants when infecting alveolar macrophages. 5 Recruitment of T cells initiates a positive feedback loop with the infected macrophages, provoking spatially limited alveolitis, which results in persistent alveolar inflammation. Tissue clearing of COVID-19-affected human lungs coupled with matrix imaging revealed that such inflammation can escalate to permanent structural loss marked by the emergence of KRT17-positive aberrant basaloid cells, a potential indicator of irreversible lung damage, underscoring the importance of lung transplant for certain patients who fail to recuperate. 6 The probability of sufficient lung function recovery appears to decrease over time while receiving extracorporeal support whereas the risk of death increases, 7 leading many centers, ours included, to contemplate the possibility of transplant after a minimum of 6 weeks of extracorporeal respiratory support. This consideration is particularly pertinent in cases of persistent severe ARDS and the development of medically refractory complications, antimicrobial resistant pneumonia, and