Upright magnetic resonance imaging of the lumbar spine: Back pain and radiculopathy

Nguyen, Ha Son; Doan, Ninh; Shabani, Saman; Baisden, Jamie; Wolfla, Christopher E.; Paskoff, Glenn; Shender, Barry S.; Stemper, Brian D.

doi:10.4103/0974-8237.176619

Cited by 20 publications

(14 citation statements)

References 39 publications

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“…To quantify posterior IVD dimension the measurement tool in the Radiant viewer software was utilized. A vertical line was used to measure the perpendicular distance between the most posterior edge of the corresponding vertebral bodies to the most posterior point of the posterior disc in millimeters [ 37 – 39 ]. The pre- and post-treatment posterior IVD dimensions could thus be objectively compared.…”

Section: Methodsmentioning

confidence: 99%

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

et al. 2017

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BackgroundDegenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs). The use of bone marrow-derived MSCs for the treatment of DDD is promising and in the present study we report on the safety and efficacy findings from a registry based proof of concept study using a percutaneous intradiscal injection of cultured MSCs for the management of DDD with associated radicular symptoms.MethodsThirty-three patients with lower back pain and disc degeneration with a posterior disc bulge diagnosed on magnetic resonance imaging (MRI) met the inclusion criteria and were treated with culture-expanded, autologous, bone marrow-derived MSCs. Prospective registry data was obtained at multiple time intervals up to 6 years post-treatment. Collected outcomes included numeric pain score (NPS), a modified single assessment numeric evaluation (SANE) rating, functional rating index (FRI), measurement of the intervertebral disc posterior dimension, and adverse events.ResultsThree patients reported pain related to procedure that resolved. There were no serious adverse events (i.e. death, infection, or tumor) associated with the procedure. NPS change scores relative to baseline were significant at 3, 36, 48, 60, and 72 months post-treatment. The average modified SANE ratings showed a mean improvement of 60% at 3 years post-treatment. FRI post-treatment change score averages exceeded the minimal clinically important difference at all time points except 12 months. Twenty of the patients treated underwent post-treatment MRI and 85% had a reduction in disc bulge size, with an average reduction size of 23% post-treatment.ConclusionsPatients treated with autologous cultured MSCs for lower back pain with radicular symptoms in the setting of DDD reported minor adverse events and significant improvements in pain, function, and overall subjective improvement through 6 years of follow-up.NCT03011398. A Clinical Registry of Orthobiologics Procedures. https://clinicaltrials.gov/ct2/show/NCT03011398?term=orthobiologics&rank=1

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Section: Methodsmentioning

confidence: 99%

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

et al. 2017

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“…In general, low back pain is one of the most common problems. [ 13 14 15 16 17 ] One of its causes is lumbar disc which may migrate superiorly, inferiorly, or laterally. Posterior migration of sequestered disc fragment is very uncommon,[ 7 ] but we first time report the perforation of LF by such a disc fragment.…”

Section: Discussionmentioning

confidence: 99%

First report of perforation of ligamentum flavum by sequestrated lumbar intervertebral disc

Özdemi̇r

Kanat

Batçık

et al. 2017

J Craniovert Jun Spine

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Disc fragments are well known to migrate to superior, inferior, or lateral sites in the anterior epidural space, posterior epidural migrated lumbar disc fragments is an extremely rare disorder, 61 cases have been reported to date. However, there were no cases with perforated ligamentum flavum (LF). We report a different case with perforation of ligamentum ligamentum by disc fragment. To the best of our knowledge, this is the first report of perforation LF by a posterior epidural migrated sequester disc.

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“…Patients with lumbar radiculopathy in the disorder of an absolute indication should pass through surgery [12]. Some MR imaging studies to diagnose lumbar radiculopathy such as Nguyen et al (2016) used upright imaging to accentuate disc pathology to obtain better diagnosis [13]. Harrell (2017) wrote that MR imaging was appropriate whether in acute, subacute, or chronic lumbar radiculopathy [14].…”

Section: Figure 1 Regions Of Vertebral Column In a Mr Imagementioning

confidence: 99%

Enhancement on Enlarge Image for Identification Lumbar Radiculopathy at Magnetic Resonance Imaging

Yunus¹,

Harlan²,

Santony³

et al. 2020

TEM Journal

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Spinal nerve root pinched by herniated intervertebral disc will yield to painful complaints. Such condition in medical term is called as radiculopathy. The lesion usually occurs in the lower part of vertebral column, i.e. lumbar radiculopathy. To verify the diagnosis, the patient should undergo magnetic resonance imaging (MRI) examination. Further image processing is needed to aid the interpretation of these MRI images. The data in this study consisted of 40 MRI images, obtained by using General Electric Brivo MR 355 in T2-weighted sagittal relaxation phase, which are to be processed later by enlarged and enhancement processing. The image processing produced larger and clearer images, making it easier to observe lumbar radiculopathy. This method serves as a new breakthrough for the health providers in the management of lumbar radiculopathy patients.

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Upright magnetic resonance imaging of the lumbar spine: Back pain and radiculopathy

Cited by 20 publications

References 39 publications

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

First report of perforation of ligamentum flavum by sequestrated lumbar intervertebral disc

Enhancement on Enlarge Image for Identification Lumbar Radiculopathy at Magnetic Resonance Imaging

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