Upregulation of thyroid transcription factor-1 and human leukocyte antigen class I in Hashimoto's disease providing a clinical evidence for possible triggering autoimmune reaction

Huang, Huibin; Li, Xisheng; Li, Gang; Shi, Yue; Lin, Xiahong; Liangyi, LI; Xu, Dongming

doi:10.1530/eje-10-0960

Cited by 14 publications

(12 citation statements)

References 29 publications

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“…Hyperexpression of HLA class I, a well‐documented effect of IFN stimulation, is evident in autoimmune disorders such as T1D and AITD . To assess such a potential effect of IFNs on adrenocortical cells, we evaluated HLA class I surface expression on H295R cells by flow cytometry after 24 h of stimulation.…”

Section: Resultsmentioning

confidence: 99%

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The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease

Hellesen

Edvardsen

Breivik

et al. 2014

Clinical and Experimental Immunology

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Section: Resultsmentioning

confidence: 99%

“…Increased expression of autoantigens may serve as a contributing factor to the induction of autoimmune responses . Therefore, we determined the effect of IFNs [and poly (I : C)] on the expression of 21‐hydroxylase (21OH) mRNA in H295R cells by quantitative PCR.…”

Section: Resultsmentioning

confidence: 99%

The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease

Hellesen

Edvardsen

Breivik

et al. 2014

Clinical and Experimental Immunology

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“…[25][26][27][28] High levels of TTF-1 expression, as seen in some forms of lung cancer, may result in increased production of SP-A and other SPs and have been shown to cause pulmonary infl ammation and fi brosis in mice. [29][30][31][32] Increased TTF-1 expression has been demonstrated in patients with chronic autoimmune thyroiditis, 33 raising the question of whether increased TTF-1 related to HT may contribute to the increased SP production observed in some patients with IPF.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Oldham

Kumar

Lee

et al. 2015

CHEST

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BACKGROUND:A signifi cant minority of patients with idiopathic pulmonary fi brosis (IPF) display features of autoimmunity without meeting the criteria for overt connective tissue disease. A link between IPF and other immune-mediated processes, such as hypothyroidism (HT), has not been reported. In this investigation, we aimed to determine whether HT is associated with IPF and if outcomes diff er between patients with IPF with and without HT.

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“…HLA class I molecules play a pivotal role in the antigen presentation and T cell activation. Failure to appropriately regulate HLA class I expressions is related to a variety of autoimmune disorders, including HD . HLA class I molecules preferentially present peptide antigens derived from viruses, which have been proposed to be key environmental triggers for autoimmune thyroid diseases.…”

Section: Discussionmentioning

confidence: 99%

The HLA‐B gene and Hashimoto disease in Han Chinese children: a case‐control and family‐based study

et al. 2012

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Hashimoto disease (HD) is an autoimmune thyroid disease resulting from complex interactions between genetic and environmental factors. The human leukocyte antigen (HLA) gene has been established to be involved in the susceptibility to HD. We aim to investigate the associations between HLA-B alleles and Han Chinese children with HD by both case-control and family-based studies. A total of 108 unrelated children with HD, 380 unrelated healthy controls, 58 trios of affected patients and their parents, and 75 trios of unaffected siblings and their parents were recruited. HLA-B genotyping was performed by polymerase chain reaction and detected with a sequence-specific oligonucleotide probes system. We found that B*46:01 allele (OR = 2.31, 95% CI 1.60-3.34, P(c) = 9.99 × 10(-5)) and carrier (OR = 3.28, 95% CI 2.10-5.11, P(c) = 1.35 × 10(-6)) were associated with HD risk. Transmission/disequilibrium test further confirmed an overtransmission of the B*46:01 (OR 2.55, 95% CI 1.36-6.10, P = 6.5 × 10(-3)). The findings were similar in females when stratified by gender. In conclusion, our results clearly identify that HLA-B*46:01 confers susceptibility to HD in Han Chinese children. Further studies with larger children cohort are required to confirm the role of B*46:01 in the development of HD.

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Upregulation of thyroid transcription factor-1 and human leukocyte antigen class I in Hashimoto's disease providing a clinical evidence for possible triggering autoimmune reaction

Abstract: Upregulation of TTF-1 and HLA class I in Hashimoto's disease provide a clinical evidence for possible triggering of autoimmune reaction.

Cited by 14 publications

References 29 publications

The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease

The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

The HLA‐B gene and Hashimoto disease in Han Chinese children: a case‐control and family‐based study

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