Upregulation of the long non‐coding RNA FALEC promotes proliferation and migration of prostate cancer cell lines and predicts prognosis of PCa patients

Zhao, Ruizhe; Sun, Feng; Bei, Xiao-Yu; Wang, Xingjie; Zhu, Yiping; Jiang, Chuanwen; Zhao, Fu-Jun; Han, Bangmin; Xia, Shujie

doi:10.1002/pros.23367

Cited by 48 publications

(22 citation statements)

References 24 publications

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“…As various noncoding RNAs are transcribed from genomes, most studies focus on microRNAs and lncRNAs from transcribing genomes . Abnormal regulation of lncRNA has been found in some types of cancer, for instance, oral, gastric, and prostate cancers . Among these differentially expressed lncRNAs, a novel lncRNA, LINC00094, was discovered, which was obviously highly expressed in lung cancer tissues compared to normal tissues and could be a prognostic biomarker of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Differential protein‐coding gene and long noncoding RNA expression in smoking‐related lung squamous cell carcinoma

Sun

Miao

et al. 2017

Thoracic Cancer

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BackgroundCigarette smoking is one of the greatest preventable risk factors for developing cancer, and most cases of lung squamous cell carcinoma (lung SCC) are associated with smoking. The pathogenesis mechanism of tumor progress is unclear. This study aimed to identify biomarkers in smoking‐related lung cancer, including protein‐coding gene, long noncoding RNA, and transcription factors.MethodsWe selected and obtained messenger RNA microarray datasets and clinical data from the Gene Expression Omnibus database to identify gene expression altered by cigarette smoking. Integrated bioinformatic analysis was used to clarify biological functions of the identified genes, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, the construction of a protein–protein interaction network, transcription factor, and statistical analyses. Subsequent quantitative real‐time PCR was utilized to verify these bioinformatic analyses.ResultsFive hundred and ninety‐eight differentially expressed genes and 21 long noncoding RNA were identified in smoking‐related lung SCC. GO and KEGG pathway analysis showed that identified genes were enriched in the cancer‐related functions and pathways. The protein–protein interaction network revealed seven hub genes identified in lung SCC. Several transcription factors and their binding sites were predicted. The results of real‐time quantitative PCR revealed that AURKA and BIRC5 were significantly upregulated and LINC00094 was downregulated in the tumor tissues of smoking patients. Further statistical analysis indicated that dysregulation of AURKA, BIRC5, and LINC00094 indicated poor prognosis in lung SCC.ConclusionProtein‐coding genes AURKA, BIRC5, and LINC00094 could be biomarkers or therapeutic targets for smoking‐related lung SCC.

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Section: Discussionmentioning

confidence: 99%

Differential protein‐coding gene and long noncoding RNA expression in smoking‐related lung squamous cell carcinoma

Sun

Miao

et al. 2017

Thoracic Cancer

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“…Similar to the classical interactive mode between HIF-1α and miRNAs, HIF-1α can also directly interact with the HREs in the lncRNA BC005927 promoter region, inducing lncRNA BC005927 to play its oncogenic role in gastric cancer by upregulating EPH receptor B4 (EPHB4) [81]. In addition, HIF-1α-mediated direct interactions regulate the expression of numerous lncRNAs, including lncRNA BX111 [82], lncRNA UCA1 [83,84], lncRNA FALEC [85], lncRNA MALAT1 [86], lncRNA ANRIL [87], and lncRNA NUTF2P3-001 [88], all of which play key roles in the development of tumors. Knowing of the existence of a direct interaction of HIF-1α and the HRE region existing in the lncRNA HOTAIR promoter in non-small-cell lung cancer [89], Bhan et al argued that synchronously with this interaction, MLL1 and CBP/p300 are recruited to the lncRNA HOTAIR promoter region, cooperating with HIF-1α to evoke the HOTAIR gene and promote tumorigenesis [90].…”

Section: Direct Regulation Of Hrl Transcription By Hif-1αmentioning

confidence: 99%

“…Although belonging to the lncRNA family, circRNAs are always discussed separately due to their unique structure gastric cancer upregulation transcriptional activation promotes invasion and metastasis [81] lncRNA BX111 pancreatic cancer upregulation transcriptional activation promotes EMT, proliferation, migration and invasion [82] lncRNA UCA1 osteosarcoma upregulation transcriptional activation promotes growth [83] lncRNA UCA1 bladder cancer upregulation transcriptional activation promotes proliferation, migration and invasion, inhibits apoptosis [84] lncRNA FALEC prostate cancer upregulation transcriptional activation promotes proliferation, migration and invasion [85] lncRNA MALAT1 HeLa and HEK-293T cells upregulation transcriptional activation N.A. [86] lncRNA ANRIL osteosarcoma upregulation transcriptional activation promotes invasion, inhibits apoptosis [87] lncRNA NUTF2P3-001 pancreatic cancer upregulation transcriptional activation promotes viability, proliferation and invasion [88] lncRNA HOTAIR lung cancer upregulation transcriptional activation promotes proliferation, migration and invasion [89] lncRNA HOTAIR pan-cancer upregulation transcriptional activation N.A.…”

Section: Regulation Of Circrnas By Hif-1αmentioning

confidence: 99%

The interplay between HIF-1α and noncoding RNAs in cancer

Peng

Han

et al. 2020

J Exp Clin Cancer Res

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Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α), the most important transcriptional regulator in the response to hypoxia, has been demonstrated to significantly modulate hypoxic gene expression and signaling transduction networks. In past few decades, growing numbers of studies have revealed the importance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. These hypoxia-responsive ncRNAs (HRNs) play pivotal roles in regulating hypoxic gene expression at the transcriptional, posttranscriptional, translational and posttranslational levels. In addition, as a significant gene expression regulator, ncRNAs exhibit promising roles in regulating HIF-1α expression at multiple levels. In this review, we briefly elucidate the reciprocal regulation between HIF-1α and ncRNAs, as well as their effect on cancer cell behaviors. We also try to summarize the complex feedback loop existing between these two components. Moreover, we evaluated the biomarker potential of HRNs for the diagnosis and prognosis of cancer, as well as the potential clinical utility of shared regulatory mechanisms between HIF-1α and ncRNAs in cancer treatment, providing novel insights into tumorigenicity, which may lead to innovative clinical applications.

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“…Zhao et al., reported that FALEC expression is significantly increased in PCa tissue samples compared to adjacent normal tissue [ 19 ]. This study reported that knockdown of FALEC inhibited cell proliferation, migration and invasion in vitro .…”

Section: Lncrnas Associated With Prostate Cancermentioning

confidence: 99%

Carcinogenesis in prostate cancer: The role of long non-coding RNAs

Aird

Baird

Lim

et al. 2018

Non-coding RNA Research

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LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway.

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Upregulation of the long non‐coding RNA FALEC promotes proliferation and migration of prostate cancer cell lines and predicts prognosis of PCa patients

Abstract: These findings suggested that FALEC may be a potential diagnostic and therapeutic target in patients with prostate cancer.

Cited by 48 publications

References 24 publications

Differential protein‐coding gene and long noncoding RNA expression in smoking‐related lung squamous cell carcinoma

Differential protein‐coding gene and long noncoding RNA expression in smoking‐related lung squamous cell carcinoma

The interplay between HIF-1α and noncoding RNAs in cancer

Carcinogenesis in prostate cancer: The role of long non-coding RNAs

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