Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer

Kang, Min Sung; Kim, Jong-Tae; Kim, Joo Heon; Kim, Soo‐Young; Kim, Young Ho; Yeom, Young Il; Lee, Younghee; Lee, Hee Gu

doi:10.1007/s00432-008-0510-3

Cited by 34 publications

(34 citation statements)

References 35 publications

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“…Overall, these studies and our work point to CKS2 as a robust marker associated with meningioma recurrence and malignant transformation. Cks2 is required for the first metaphase/anaphase transition of mammalian meiosis, and was also found to be upregulated in colon cancer metastases [33,34], prostate and gastric cancer [35,36], and hepatocellular carcinomas [37]. Recent data showed that gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 [38].…”

Section: Discussionmentioning

confidence: 99%

DNA Microarray Analysis Identifies CKS2 and LEPR as Potential Markers of Meningioma Recurrence

Menghi¹,

Orzan²,

Eoli³

et al. 2011

The Oncologist

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Meningiomas are the most frequent intracranial tumors. Surgery can be curative, but recurrences are possible. We performed gene expression analyses and loss of heterozygosity (LOH) studies looking for new markers predicting the recurrence risk. We analyzed expression profiles of 23 meningiomas (10 grade I, 10 grade II, and 3 grade III) and validated the data using quantitative polymerase chain reaction (qPCR). We performed LOH analysis on 40 meningiomas, investigating chromosomal regions on 1p, 9p, 10q, 14q, and 22q. We found 233 and 268 probe sets to be significantly down-and upregulated, respectively, in grade II or III meningiomas. Genes downregulated in high-grade meningiomas were overrepresented on chromosomes 1, 6, 9, 10, and 14. Based on functional enrichment analysis, we selected LIM domain and actin binding 1 (LIMA1), tissue inhibitor of metalloproteinases 3 (TIMP3), cyclin-dependent kinases regulatory subunit 2 (CKS2), leptin receptor (LEPR), and baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) for validation using qPCR and confirmed their differential expression in the two groups of tumors. We calculated ⌬Ct values of CKS2 and LEPR and found that their differential expression (C-L index) was significantly higher in grade I than in grade II or III meningiomas (p < .0001). Interestingly, the C-L index of nine grade I meningiomas from patients who relapsed in <5 years was significantly lower than in grade I meningiomas from patients who did not relapse. These findings indicate that the C-L index may be relevant to define the progression risk in meningioma patients, helping guide their clinical management. A prospective analysis on a larger number of cases is warranted.

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Section: Discussionmentioning

confidence: 99%

DNA Microarray Analysis Identifies CKS2 and LEPR as Potential Markers of Meningioma Recurrence

Menghi¹,

Orzan²,

Eoli³

et al. 2011

The Oncologist

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“…Of the 40 cases with high CKS2 expression, 32 (80%) had lymph node metastasis, indicating that CKS2 promotes lymph node metastasis. Kang et al (28) also observed the correlation between high CKS2 expression and lymph node metastasis in gastric cancer tissues. (31) identified the gene expression in 29 cervical cancer patients with and 19 patients without lymph node metastases using a genomic microarray technique.…”

Section: Cks2 Promotes Cancer Invasion and Metastasis Cks2 Promotes Cmentioning

confidence: 92%

“…In other malignant tumors, such as glioma (19,20), multiple myeloma (21), follicular thyroid carcinoma (22), prostate cancer (23), malignant melanoma (24), cervical cancer (25), laryngeal squamous cell carcinoma (26) and meningioma (27), CKS2 was also highly expressed. (28) performed immunohistochemical staining analyses and identified that CKS2 was more strongly expressed in the less differentiated area compared to the well differentiated area, even in the same tumor tissue of each patient, occasionally. The study divided 60 cases of gastric cancer tissues into two groups; low and high CKS2 expression levels.…”

Section: Cks2 Is Highly Expressed In Malignant Tumorsmentioning

confidence: 99%

“…CKS2 is a transcription target downregulated by p53 (7). Kang et al (28) used SUN638 and AGS gastric cancer cells that were transfected with GFP; GFP-CKS2 plasmids. The western blot results showed that the protein expression level of p53 in GFP-CKS2-overexpressing SUN638 and AGS cells was lower compared to the GFP control cells, suggesting that the increased CKS2 protein affected the protein level of p53.…”

Section: Molecular Mechanismsmentioning

confidence: 99%

“…Tissues from 10 gastric cancer patients were prepared and RT-qPCR analysis was performed (28). Cell cycle regulators, cyclin A, cyclin B1 and CDK1, were evidently upregulated in tumor tissues compared to normal tissues.…”

Section: Cks2 Upregulates Cyclin a Cyclin B1 And Cdk1mentioning

confidence: 99%

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CKS2 in human cancers: Clinical roles and current perspectives (Review)

You

Lin

Zhang

2015

Molecular and Clinical Oncology

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Abstract. Cyclin-dependent kinase subunit 2 (CKS2) is indicated in the processes of cell cycle and cell proliferation. Through these processes, CKS2 is identified as a cancer gene, but its role has not been well reviewed. The aim of the present study was to summarize the clinicopathological significance and the molecular mechanisms of CKS2 in human cancers. Its expression was upregulated in the majority of the types of cancer studied. CKS2 was shown to have a function in cancers of the digestive tract, genital tract, thyroid, nerve and certain other types of cancer. CKS2 can promote progression of certain cancers via positive control of proliferation, invasion and migration. Downregulation of CKS2 induces cancer cell apoptosis. CKS2 can change a multitude of cellular mechanisms in cancer pathogenesis by regulating the gene translation of numerous validated targets, such as p53, CDK1, cyclin A, cyclin B1, caspase-3 and Bax. In addition, the molecular mechanism that causes aberrant expression of CKS2 was epigenetic modification of miR-26a and the Y-box-binding protein 1 (YB-1) gene. In conclusion, CKS2 is commonly elevated in cancer, most likely due to its ability to promote cancer cell growth, invasion and migration through regulating certain significant genes. Understanding the mechanisms by which CKS2 is involved with cancer pathogenesis will be useful in the development of tumor therapy for patients with cancer.

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Genetics of breast cancer bone metastasis: a sequential multistep pattern

Fazilaty

Mehdipour

2014

Clin Exp Metastasis

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Bone metastasis accounts for the vast majority of breast cancer (BC) metastases, and is related to a high rate of morbidity and mortality. A number of seminal studies have uncovered gene expression signatures involved in BC development and bone metastasis; each of them points at a distinct step of the 'invasion-metastasis cascade'. In this review, we provide most recently discovered functions of sets of genes that are selected from widely accepted gene signatures that are implicate in BC progression and bone metastasis. We propose a possible sequential pattern of gene expression that may lead a benign primary breast tumor to get aggressiveness and progress toward bone metastasis. A panel of genes which primarily deal with features like DNA replication, survival, proliferation, then, angiogenesis, migration, and invasion has been identified. TGF-β, FGF, NFκB, WNT, PI3K, and JAK-STAT signaling pathways, as the key pathways involved in breast cancer development and metastasis, are evidently regulated by several genes in all three signatures. Epithelial to mesenchymal transition that is also an important mechanism in cancer stem cell generation and metastasis is evidently regulated by these genes. This review provides a comprehensive insight regarding breast cancer bone metastasis that may lead to a better understanding of the disease and take step toward better treatments.

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Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer

Cited by 34 publications

References 35 publications

DNA Microarray Analysis Identifies CKS2 and LEPR as Potential Markers of Meningioma Recurrence

DNA Microarray Analysis Identifies CKS2 and LEPR as Potential Markers of Meningioma Recurrence

CKS2 in human cancers: Clinical roles and current perspectives (Review)

Genetics of breast cancer bone metastasis: a sequential multistep pattern

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