Upregulation of Runt related transcription factor 1 (RUNX1) contributes to tendon–bone healing after anterior cruciate ligament reconstruction using bone mesenchymal stem cells

Kang, Kai; Qian, Geng; Cui, Lukuan; Wu, Lijie; Zhang, Lei; Li, Tong; Zhang, Qian; Gao, Shijun

doi:10.1186/s13018-022-03152-y

Cited by 8 publications

(7 citation statements)

References 38 publications

(43 reference statements)

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“…Preclinical studies have demonstrated that MSCs can promote tendon-bone healing and reduce the expansion of bone tunnels ( Jang et al, 2015 ; Chen et al, 2021 ). Due to the differences in the differentiation directions of MSCs from different sources, the efficacy of different MSCs in promoting tendon-bone healing varies greatly ( Kang et al, 2022 ). In order to overcome this problem, researchers tried to use gene modification technology to control the differentiation direction of MSCs, and achieved success in basic research ( Chen et al, 2016 ; Kang et al, 2022 ).…”

Section: Discussion and Outlookmentioning

confidence: 99%

“…Due to the differences in the differentiation directions of MSCs from different sources, the efficacy of different MSCs in promoting tendon-bone healing varies greatly ( Kang et al, 2022 ). In order to overcome this problem, researchers tried to use gene modification technology to control the differentiation direction of MSCs, and achieved success in basic research ( Chen et al, 2016 ; Kang et al, 2022 ). It solves the problem that MSCs from different sources can be applied to promote tendon-bone healing.…”

Section: Discussion and Outlookmentioning

confidence: 99%

“…In this process, the synergistic effect of BMP2 and bFGF was greater than that of single genes. Recently, Kang et al (2022) studied the effect of RUNt-related transcription factor 1 (RUNX1) overexpressed BMSCs on stenon-bone healing after ACL reconstruction. The results suggest that the increased expression of RUNX1 can improve the ability of BMSCs to promote tendon-bone healing after ACL reconstruction.…”

Section: Preclinical Study Of Strategies To Promote Tendon-bone Heali...mentioning

confidence: 99%

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Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

Tian

Zhang

Kang

2023

Front. Bioeng. Biotechnol.

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At present, anterior cruciate ligament (ACL) reconstruction still has a high failure rate. Tendon graft and bone tunnel surface angiogenesis and bony ingrowth are the main physiological processes of tendon-bone healing, and also the main reasons for the postoperative efficacy of ACL reconstruction. Poor tendon-bone healing has been also identified as one of the main causes of unsatisfactory treatment outcomes. The physiological process of tendon-bone healing is complicated because the tendon-bone junction requires the organic fusion of the tendon graft with the bone tissue. The failure of the operation is often caused by tendon dislocation or scar healing. Therefore, it is important to study the possible risk factors for tendon-bone healing and strategies to promote it. This review comprehensively analyzed the risk factors contributing to tendon-bone healing failure after ACL reconstruction. Additionally, we discuss the current strategies used to promote tendon-bone healing following ACL reconstruction.

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Section: Discussion and Outlookmentioning

confidence: 99%

Section: Discussion and Outlookmentioning

confidence: 99%

Section: Preclinical Study Of Strategies To Promote Tendon-bone Heali...mentioning

confidence: 99%

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Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

Tian

Zhang

Kang

2023

Front. Bioeng. Biotechnol.

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“…This study also found that BMSCs overexpressing PDGF-B could enhance tendon-bone healing after RCT repair. In addition, a recent study by (Kang et al, 2022) found that RUNt-related transcription factor 1 (RUNX1) gene modified MSCs also produced better efficacy in tendon-bone healing. The above studies indicate that genetic engineering technology can make up for the lack of differentiated ability of BMSCs from different sources.…”

Section: Gong Et Al (2022)mentioning

confidence: 99%

Strategies for promoting tendon-bone healing: Current status and prospects

Yang

Teng²,

Geng³

et al. 2023

Front. Bioeng. Biotechnol.

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Tendon-bone insertion (TBI) injuries are common, primarily involving the rotator cuff (RC) and anterior cruciate ligament (ACL). At present, repair surgery and reconstructive surgery are the main treatments, and the main factor determining the curative effect of surgery is postoperative tendon-bone healing, which requires the stable combination of the transplanted tendon and the bone tunnel to ensure the stability of the joint. Fibrocartilage and bone formation are the main physiological processes in the bone marrow tract. Therefore, therapeutic measures conducive to these processes are likely to be applied clinically to promote tendon-bone healing. In recent years, biomaterials and compounds, stem cells, cell factors, platelet-rich plasma, exosomes, physical therapy, and other technologies have been widely used in the study of promoting tendon-bone healing. This review provides a comprehensive summary of strategies used to promote tendon-bone healing and analyses relevant preclinical and clinical studies. The potential application value of these strategies in promoting tendon-bone healing was also discussed.

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“…It improves the synthesis and deposition of bone matrix proteins and finally promotes bone remodeling. 18 This remodeling process continues for months or even years, gradually restoring the bone's strength and structure.…”

Section: 2mentioning

confidence: 99%

Attributes of Nanomaterials and Nanotopographies for Improved Bone Tissue Engineering and Regeneration

Karmakar,

Dey,

Alam

et al. 2023

ACS Appl. Bio Mater.

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Bone tissue engineering (BTE) is a multidisciplinary area that can solve the limitation of conventional grafting methods by developing viable and biocompatible bone replacements. The three essential components of BTE, i.e., Scaffold material and Cells and Growth factors altogether, facilitate support and guide for bone formation, differentiation of the bone tissues, and enhancement in the cellular activities and bone regeneration. However, there is a scarcity of the appropriate materials that can match the mechanical property as well as functional similarity to native tissue, considering the bone as hard tissue. In such scenarios, nanotechnology can be leveraged upon to achieve the desired aspects of BTE, and that is the key point of this review article. This review article examines the significant areas of nanotechnology research that have an impact on regeneration of bone: (a) scaffold with nanomaterials helps to enhance physicochemical interactions, biocompatibility, mechanical stability, and attachment; (b) nanoparticle-based approaches for delivering bioactive chemicals, growth factors, and genetic material. The article begins with the introduction of components and healing mechanisms of bone and the factors associated with them. The focus of this article is on the various nanotopographies that are now being used in scaffold formation, by describing how they are made, and how these nanotopographies affect the immune system and potential underlying mechanisms. The advantages of 4D bioprinting in BTE by using nanoink have also been mentioned. Additionally, we have investigated the importance of an in silico approach for finding the interaction between drugs and their related receptors, which can help to formulate suitable systems for delivery. This review emphasizes the role of nanoscale approach and how it helps to increase the efficacy of parameters of scaffold as well as drug delivery system for tissue engineering and bone regeneration.

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Upregulation of Runt related transcription factor 1 (RUNX1) contributes to tendon–bone healing after anterior cruciate ligament reconstruction using bone mesenchymal stem cells

Cited by 8 publications

References 38 publications

Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

Strategies for promoting tendon-bone healing: Current status and prospects

Attributes of Nanomaterials and Nanotopographies for Improved Bone Tissue Engineering and Regeneration

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