Upregulation of Neutrophil Surface Adhesion Molecules in Infants of Pre-eclamptic Women

Saini, Hemant; Puppala, Bhagya L.; Angst, Denise B.; Gilman‐Sachs, Alice; Costello, Michael

doi:10.1038/sj.jp.7211056

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…Different expressions of adhesion molecules on neutrophils, namely, integrins, selectins, and Ig superfamily, were shown to be upregulated in infants from PE pregnancies [46, 58] suggesting an interaction between neutrophils and endothelial cells. Nevertheless, Mellembakken et al [46] also reported, in the same samples, that plasma levels of soluble L-selectin were significantly decreased in PE infants.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

Catarino

Santos-Silva

Belo

et al. 2012

Journal of Pregnancy

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Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation. Our aim was to evaluate and compare the levels of oxidative stress and inflammatory markers in maternal and umbilical cord blood (UCB), in normal and PE pregnancies. We measured acute-phase proteins (CRP and α1-antitrypsin), proinflammatory cytokines (IL-6 and TNF-α), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), and uric acid levels. We studied 42 healthy pregnant women, 46 PE women, and their neonates. The concentrations of IL-6, TNF-α, α1-antitrypsin, CRP, sVCAM, uric acid, and TBARS were significantly higher, and sL-selectin was significantly lower in PE pregnant women as compared with normotensive pregnant women. In newborns uric acid, α1-antitrypsin, and CRP values were significantly higher in PE; leukocyte count, sL-selectin, lactoferrin, and the ratio elastase/α1-antitrypsin were significantly lower. Our data suggest that PE pregnancy is associated with an enhanced maternal inflammatory condition, which is reflected in fetal circulation. This enhanced inflammatory state seems to be related to endothelial dysfunction and increased cytokine synthesis, rather than with neutrophil activation.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

Catarino

Santos-Silva

Belo

et al. 2012

Journal of Pregnancy

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“…Elevated levels of adhesion molecules were found in neonates born to mothers with preeclampsia, indicating the presence of activated neutrophils (56). The expression of surface adhesion molecules on cord blood neutrophils was significantly higher in infants born to women with preeclampsia than in infants born to the control subjects.…”

Section: Leukocyte Activation and Its Role In Preeclampsiamentioning

confidence: 98%

The Role of Placental Oxidative Stress and Lipid Peroxidation in Preeclampsia

Gupta

Agarwal²,

Sharma³

2005

Obstetrical & Gynecological Survey

152

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“…Cord blood samples (lacking in this study) would provide information on possible intrauterine inflammation. Increased CD11b expression has been found in cord blood from preterm infants born after preeclampsia, suggesting antenatal neutrophil activation [30] . When compared with infants born to mothers with uncomplicated preeclampsia, infants born to mothers with preeclampsia complicated by HELLP syndrome show increased oxidative stress and increased concentrations of proinflammatory cytokines [31] .…”

Section: Discussionmentioning

confidence: 99%

Increased Postnatal Inflammation in Mechanically Ventilated Preterm Infants Born to Mothers with Early-Onset Preeclampsia

Turunen¹,

Andersson²,

Laivuori³

et al. 2011

Neonatology

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Background: Preeclampsia and preterm labor often underlie preterm birth, and are associated with maternal inflammation. In preterm infants, respiratory distress syndrome (RDS) and mechanical ventilation are associated with systemic inflammation. Objective: We aimed to study whether early-onset preeclampsia or preterm labor modulate the systemic inflammation affecting preterm infants with RDS. Methods: We recruited mechanically ventilated infants with gestational ages <32 weeks; 11 infants were born after early-onset preeclampsia and 25 after preterm labor. Blood was drawn during postnatal days 1–7, and the mean values of days 1–2, 3–4 and 5–6 were used. Phagocyte CD11b expression was analyzed with flow cytometry, and plasma C-reactive protein (CRP) concentrations with immunoturbidimetry. Results: As compared with infants born after preterm labor, infants born after early-onset preeclampsia had higher CD11b expression on days 1–6 on both neutrophils and monocytes. In addition, infants born after early-onset preeclampsia had higher CRP concentrations on days 2–6 (all p < 0.05). Conclusions: As compared with infants born after preterm labor to mothers without preeclampsia, infants born after early-onset preeclampsia presented with a stronger postnatal systemic inflammatory reaction. Antenatal exposure to preeclampsia may induce fetal leukocyte priming and regulation of inflammation, and thereby modify postnatal inflammatory reactions and morbidity.

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Upregulation of Neutrophil Surface Adhesion Molecules in Infants of Pre-eclamptic Women

Abstract: This study revealed neutrophil activation in infants born to pre-eclamptic women. The relationship between neutrophil activation and severity of pre-eclampsia warrants further study.

Cited by 9 publications

References 37 publications

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

The Role of Placental Oxidative Stress and Lipid Peroxidation in Preeclampsia

Increased Postnatal Inflammation in Mechanically Ventilated Preterm Infants Born to Mothers with Early-Onset Preeclampsia

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