Abstract:The nervous system can regulate the exacerbation of pro-inflammatory immune response predominantly in an immunosuppressive setting. Studies also suggest that glutamate, serotonin, dopamine, and substance P trigger immune responses such as cytokine secretion, integrin expression, and chemotaxis. We evaluated the role of neurotransmitters in modulating and/or activating T cells in mouse tumor models of kidney (RencaHA) and breast cancers (4T1HA) expressing viral hemagglutinin as a defined immunodominant antigen.… Show more
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