Upregulation of MTOR, RPS6KB1, and EIF4EBP1 in the whole blood samples of Iranian patients with multiple sclerosis compared to healthy controls

Akbarian, Fahimeh; Tabatabaiefar, Mohammad Amin; Shaygannejad, Vahid; Shahpouri, Mohammad Mahdi; Badihian, Negin; Sajjadi, Roshanak S; Dabiri, Arezou; Jalilian, Nasrin; Noori–Daloii, Mohammad Reza

doi:10.1007/s11011-020-00590-7

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…We observed that hsa-miR-125b-5p interacted with EIF4EBP1 to modulate the progress of BC. Akbarian et al also pointed out that EIF4EBP1 was upregulated in multiple sclerosis patients compared to healthy controls [33]. Tumor progression can usually be reflected by DUSP1, which stimulates the progression of tumor after drug resistance.…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel CircRNA-miRNA-mRNA Regulatory Network and Its Prognostic Prediction in Breast Cancer

Huang

Zhong³

2021

Evidence-Based Complementary and Alternative Medicine

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Aim. This study aimed to investigate the expression profiles of circRNAs and candidate circRNA-miRNA-mRNA network in BC. Methods. Differentially expressed circRNAs, miRNAs, and mRNAs (DEcircRNAs, DEmiRNAs, and DEmRNAs) between BC and normal breast tissue samples were screened by analyzing raw data of the RNA sequencing profile. The expression levels of hub genes in 48 pairs of cancerous and tumor-free breast tissues surgically resected from BC patients were determined by RT-qPCR analysis. Results. A total of 145 DEcircRNAs, 140 DEmiRNAs, and 2451 DEmRNAs between BC and normal breast tissue samples were screened out. There were 5 pairs of upcircRNA-downmiRNA-upmRNA network and 20 pairs of downcircRNA-upmiRNA-downmRNA network. EIF4EBP1, DUSP1, EGR2, EZH1, and CBX7 were found to be correlated with overall survival of the patients with BC. The expression level of EIF4EBP1 was increased and the expression levels of DUSP1, EGR2, EZH1, and CBX7 were decreased in cancerous breast tissues compared to tumor-free breast tissues p < 0.0001 . The RT-qPCR results from 48 BC patients were consistent with the bioinformatics results. Conclusion. This study provides a novel perspective to study circRNA-miRNA-mRNA network in BC and assists in the identification of new potential biomarkers to be used for diagnostic and prognostic purposes.

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Section: Discussionmentioning

confidence: 99%

Identification of Novel CircRNA-miRNA-mRNA Regulatory Network and Its Prognostic Prediction in Breast Cancer

Huang

Zhong³

2021

Evidence-Based Complementary and Alternative Medicine

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“…Although it is apparent that mTOR-related proteins are not effective prevention strategies for MS, they may be used as an objective basis for individuals with strong MS family history to assess the potential risk of disease [3,8,10].…”

Section: Discussionmentioning

confidence: 99%

“…SNHG5 has been shown to modulate a variety of immune-related microRNAs, such as miR-205-5p, miR-154-5p, and miR-26a-5p [9], while DANCR can induce the expression of IL-6 and TNF-α in monocytes, which involved in the autoimmune response of MS. In contrast, Fahimeh Akbarian et al [10] reported a higher expression of mTOR-related signals (mTOR, RPS6KB1, and EIF4EBP1) in relapsing-remitting MS.…”

Section: Introductionmentioning

confidence: 86%

Genetically determined levels of mTOR-dependent circulating proteins and risk of multiple sclerosis

Zhang

Fan

Wang

et al. 2023

Preprint

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Background Observational studies have reported an association between circulating levels of mammalian target of rapamycin (mTOR)-dependent circulating proteins and multiple sclerosis (MS). However, the casual association has not been fully elucidated. Mendelian randomization (MR) is used to overcome limitations inherent to observational studies and assess the causal association. Methods To explore the causal association between mTOR-dependent proteins (AKT, RP-S6K, eIF4E-BP, eIF4A, eIF4E, eIF4G, and PKC-α) and MS, summary statistics were obtained from GWAS meta-analysis of the International Multiple Sclerosis Genetics Consortium (47429 patients and 68374 controls) and the INTERVAL study (genetic associations with 2994 plasma proteins from 3301 healthy individuals). MR analysis and sensitivity analyses were conducted. Results Among seven selected mTOR-dependent proteins, the circulating level of PKC-α (OR = 0.90, 95%CI 0.82–0.98, P = 0.017) and RP-S6K (OR = 1.12, 95%CI 1.00-1.25, P = 0.045) were associated with MS risk, while no significant causation was found between other proteins (AKT, eIF4E-BP, eIF4A, eIF4E, eIF4G) and MS. Conclusion Molecules in the mTOR signaling pathway may bidirectionally regulate the occurrence and development of MS. PKC-α is a protective factor, while RP-S6K is a risk factor. They might be used as future therapeutic targets for screening high-risk individuals.

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“…Also, many lncRNAs are related to different types of cancers including breast cancer, glioblastoma, colorectal cancer, liver cancer, and leukemia ( 24 ). The PI3K/Akt/mTOR pathway has multiple cellular activities including cell survival, growth, proliferation, cell migration, and invasion ( 25 ). Experimental studies indicate that the pathway is necessary for the survival of the cancer stem cell population and participates in epithelial-to-mesenchymal transition (EMT) in PC cells.…”

Section: Discussionmentioning

confidence: 99%

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study

2021

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Background and purpose: Prostate cancer (PC) is the second most prevalent cancer in men. Prostate-specific antigen (PSA) is the main biomarker for screening PC. An increase in PSA could lead to false-positive results. Thus, more appropriate markers should be investigated. In the present study, JPX and LINC00641 expression levels were measured in tumoral prostate tissue compared with the non-tumor tissue. Experimental approach: 43 pairs of prostate tumoral and non-tumor tissue were prepared. The expression levels of JPX and LINC00641 were investigated by RT-qPCR. Findings/Results: Significant upregulation of LINC00641 (2.47 ± 0.5 vs 1.41 ± 0.2) and downregulation of JPX (1.42 ± 0.6 vs 2.83 ± 1.0) were observed in PC tissues compared with the normal tissues (their adjacent non-tumoral tissues). Conclusion and implications: Dysregulation of JPX and LINC00641 in PC patients could be used in the future as a prognostic biomarker in PC.

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Upregulation of MTOR, RPS6KB1, and EIF4EBP1 in the whole blood samples of Iranian patients with multiple sclerosis compared to healthy controls

Cited by 8 publications

References 32 publications

Identification of Novel CircRNA-miRNA-mRNA Regulatory Network and Its Prognostic Prediction in Breast Cancer

Identification of Novel CircRNA-miRNA-mRNA Regulatory Network and Its Prognostic Prediction in Breast Cancer

Genetically determined levels of mTOR-dependent circulating proteins and risk of multiple sclerosis

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study

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