Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients

Ham, Ok Kyung; Lee, Chang Youn; Song, Bomi; Lee, Seyeon; Kim, Ran; Park, Jun‐Hee; Lee, Jiyun; Seo, Ho Seong; Lee, Chae Yoon; Chung, Yong‐An; Maeng, Lee-So; Lee, Min Young; Kim, Jongmin; Hwang, Jihwan; Woo, Dong Kyun; Chang, Won Hyuk

doi:10.14348/molcells.2014.0023

Cited by 34 publications

(23 citation statements)

References 51 publications

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“…The SF‐derived mesenchymal stem cells (SFMSCs) collected from degenerative arthropathy patients may serve as an alternative therapeutic approach for RA and OA patients. However, upregulation of miR‐23b may further increase the autologous therapeutic potentiality in SFMSCs from RA patients . Previous study has suggested that Cyr61, fibroblast‐like synoviocytes (FLS) secreted ECM protein, promotes the proliferation of FLS and differentiation of T helper 17 cell .…”

Section: Mirna‐regulated Other Events In Ramentioning

confidence: 99%

“…However, upregulation of miR-23b may further increase the autologous therapeutic potentiality in SFMSCs from RA patients. 71 Previous study has suggested that Cyr61, fibroblast-like synoviocytes (FLS) secreted ECM protein, promotes the proliferation of FLS and differentiation of T helper 17 cell. 72 Study observed that miR-22…”

Section: B Mirnas Regulation Of Synovial Tissue and Cellsmentioning

confidence: 99%

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miRNA‐Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis

Sharma

Lee

et al. 2016

Medicinal Research Reviews

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Rheumatoid arthritis (RA) is an inflammatory disease that primarily affects joints. This autoimmune disease pathogenesis is related to cytokine signaling. In this review, we have described the existence of various microRNAs (miRNAs) involved in regulation of major protein cascades of cytokine signaling associated with RA. Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF‐α, IL‐1, IL‐6, IL‐10, IL‐17, IL‐18, IL‐21, and granulocyte macrophage colony‐stimulating factor (GMCSF). Along with this, we have also discussed the miRNA regulation in T cells and synovial tissue. From the analyzed data, we suggest that miR‐146a and miR‐155 might be the potential therapeutic target for treating RA. The insight illustrated in this review will offer a better understanding of the role of miRNA in cytokine signaling pathways and inflammation during RA and could project them as diagnostic or therapeutic agents in near future.

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Section: Mirna‐regulated Other Events In Ramentioning

confidence: 99%

Section: B Mirnas Regulation Of Synovial Tissue and Cellsmentioning

confidence: 99%

miRNA‐Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis

Sharma

Lee

et al. 2016

Medicinal Research Reviews

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“…Certain miRNAs regulate the level of MMPs indirectly through targeting other molecules. For example, miR-23b is important for chondrogenesis by targeting PRKACB and downregulating MMP-9 [111]. Furthermore, p16INK4a accumulates in OA and enhances the mRNA expression of MMP1 and MMP13 [112].…”

Section: Mirnas In Inflammation and Matrix Degradation In Osteoarthritismentioning

confidence: 99%

The Role of MicroRNAs and Their Targets in Osteoarthritis

2016

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MicroRNA regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Recent studies have focused on specific microRNAs that are differentially expressed in case of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationship of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify selected microRNAs that are differentially expressed in osteoarthritic tissue, but have unidentified targets and functions in the disease pathogenesis. Lastly, we highlight the potential use of microRNAs for therapeutic purposes, and also point to certain remedies that regulate microRNA expression.

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“…miRNA-23b overexpression induced chondrogenic differentiation by downregulating protein kinase A (PKA) signaling by targeting Prkacb that encodes a catalytic subunit of PKA, in synovial fluid-derived mesenchymal stem cells [51]; miR-23b may contribute to OA progression by inducing chondrocyte differentiation.…”

Section: Role Of Microrna In Articular Cartilage Homeostasis and Ostementioning

confidence: 99%

microRNAs in Cartilage Development, Homeostasis, and Disease

Mirzamohammadi

Papaioannou

Kobayashi

2014

Curr Osteoporos Rep

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microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network. Experimental evidence suggests that miRNAs play significant roles in various aspects of cartilage development, homeostasis, and pathology. The possibility that miRNAs can be novel therapeutic targets for cartilage diseases led to vigorous investigations to understand the role of individual miRNAs in skeletal tissues. Here, we summarize our current understanding of miRNAs in chondrocytes and cartilage. In the first part, we discuss roles of miRNAs in growth plate development and chondrocyte differentiation. In the second part, we put a particular focus on articular cartilage and discuss the significance of variety of findings in the context of osteoarthritis, the most common degenerative joint disease.

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Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients

Cited by 34 publications

References 51 publications

miRNA‐Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis

miRNA‐Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis

The Role of MicroRNAs and Their Targets in Osteoarthritis

microRNAs in Cartilage Development, Homeostasis, and Disease

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