Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer

Shen, Shuna; Wang, Ling‐Feng; Jia, Yongsheng; Hao, Yuqing; Zhang, Lin

doi:10.1186/1746-1596-8-69

Cited by 84 publications

(73 citation statements)

References 37 publications

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“…Compared with normal tissues, the expression levels of miR-224 in cervical cancer tissues are much higher. Cervical cancer patients with lymph node metastasis-positive or vascular invasion or advanced International Federation of Gynecology and Obstetrics (FIGO) stage always have higher levels of miR-224 than those with lymph node metastasis-negative (P=0.008) or without vascular invasion patients (P=0.01) or early FIGO stage (P=0.02) [61]. According to a study, the expression levels of miR-224 are significantly higher in the Barcelona Clinic Liver Cancer (BCLC) stage C patients than those with stage B patients (P=0.005) in HCC.…”

Section: Mir-224 Reflects Tumor Stagingmentioning

confidence: 99%

MicroRNA-224: as a potential target for miR-based therapy of cancer

et al. 2015

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MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.

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Section: Mir-224 Reflects Tumor Stagingmentioning

confidence: 99%

MicroRNA-224: as a potential target for miR-based therapy of cancer

et al. 2015

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“…MiRNAs are a group of endogenous evolutionarily conserved small non-coding RNAs, which have been proven to be essential in the development of PDAC, including cell proliferation, cell death, differentiation, angiogenesis, migration, metabolism, and invasion [6,10,11]. Recently, miR-224 was demonstrated to be upregulated in cervical cancer [12,13]. MiR-224 was previously described to be involved in the generation of tumors in hepatocellular carcinoma [14], and contributes to tumor migration, invasion, and cancer cell proliferation [14,15].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway

Zhu

Zhou

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: MicroRNAs (miRNAs) have been shown to participate in the development of pancreatic ductal adenocarcinoma (PDAC) by modulating multiple cellular processes. Increased miR-224 expression enhances proliferation and metastasis in human cancers. This study aimed to investigate the role of miR-224 and its underlying mechanism of action in PDAC. Methods: BrdU, MTT, and cell migration assays were performed to determine cell proliferation, viability, and migration, respectively. The binding sites of miR-224 were identified using a luciferase reporter system, whereas protein expression of target genes was determined by immunoblotting and immunofluorescence analyses. A BALB/c nude mouse xenograft model was used to evaluate the role of miR-224 in vivo. Results: We demonstrated that miR-224 expression was enhanced in PDAC cells and tissues, and was related to migration and proliferation. Noticeably, miR-224 overexpression promoted the proliferation, migration, and metastasis of Panc1 cells, while miR-224 inhibition had the reverse effect on PDAC cells. Moreover, we found that thioredoxin-interacting protein (TXNIP) is a target of miR-224. The results also indicated that miR-224 inversely regulated TXNIP by binding directly to its 3′-untranslated region, which resulted in the activation of hypoxia-inducible factor 1α (HIF1α). Further, either TXNIP re-expression or HIF1α depletion abolished the effects of miR-224 on the proliferation and migration of PDAC cells in vitro and in vivo. Regarding the relationship of TXNIP and HIF1α, we found that TXNIP mediated the nuclear export of HIF1α and its degradation by forming a complex with HIF1α. Conclusion: The miR-224-TXNIP-HIF1α axis may be useful in developing novel therapies for PDAC.

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“…Functional studies performed in cancer ce ll lines or animal models of various cancers suggest that, miRNAs can function as tumor suppressors, oncogenes, and regulate cancer pathways (Farazi et al, 2011). Aberrant expression of specific miRNAs has been reported in many tumor types 1 such as CRC, breast cancer, cervical cancer, non-small cell lung cancer, ovarian cancer and bladder cancer as well as being associated with patients' survival data, metastasis, and other clinicopathological factors (Toyama et al, 2012;Wan et al, 2012;Shen et al, 2013;Wang et al, 2013;Xiao et al, 2013;Liu et al, 2014;Xu et al, 2014). A previous study showed that miR-32 expression was upregulated in CRC tissues, and high expression was significantly correlated with the tumor stage, distal metastases and poor prognoses (Wu et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

Wu²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The incidence of colorectal cancer (CRC) is increasing in many Asian countries and microRNAs have already been proven to be associated with tumorigenesis. Currently, microRNA-376a (miR-376a) expression and association with clinical factors in CRC remains unclear. In this study, real-time quantitative reverse transcriptasepolymerase chain reaction (qRT-PCR) was carried out on 53 matched pairs of CRC and adjacent normal mucosa to investigate the expression levels of miR-376a. According to the high or low expression of miR-376a, patients were divided into two groups. The relationship between miR-376a expression and clinicopathological factors of 53 patients was evaluated. Survival analysis of 53 CRC patients was performed with clinical followup information and survival curves were assessed by the Kaplan-Meier method. Immunohistochemistry (IHC) staining was performed on sections of paraffin-embedded tissue to investigate the vascular endothelial growth factor (VEGF) expression. MiR-376a showed low expression in cancer tissues compared to the adjacent normal tissues and altered high miR-376a expression tended to be positively correlated with advanced lymph node metastasis and shorter patient survival. VEGF IHC positivity was significantly more common in patients with high expression levels of miR-376a.Those results demonstrated that miR-376a may be a meaningful prognostic biomarker and potential therapeutic target in colorectal cancer.

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Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer

Cited by 84 publications

References 37 publications

MicroRNA-224: as a potential target for miR-based therapy of cancer

MicroRNA-224: as a potential target for miR-based therapy of cancer

MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

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