Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5

Chen, Guan; Zhang, Lingling; Wang, Sixuan; Long, Luye; Zhou, Huaibin; Qian, Shihan; Ma, Mengni; Bai, Fumao; Meng, Qing H.; Lyu, Jianxin

doi:10.1080/15384047.2019.1599659

Cited by 34 publications

(30 citation statements)

References 54 publications

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“…[20][21][22] Aberrant miRNA expression has been frequently identified in PCa and demonstrated to be closely associated with prostate carcinogenesis, including PCa progression. [23][24][25] In addition, miRNAs are regarded as perfect candidates for identifying tumor diagnosis and prognosis biomarkers. 26,27 Therefore, an in-depth exploration of PCa-related miRNAs may offer novel insights into the molecular pathways underlying PCa progression and facilitate the identification of novel targets for anticancer therapy.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-939 Directly Targets HDGF to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway

Song¹,

Zhang²,

Zi³

et al. 2020

OTT

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MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis. Methods: miR-939 expression was determined in PCa tissues and cell lines using reverse transcription-quantitative polymerase chain reaction. Cell Counting Kit-8, colony formation, and flow cytometric assays were used to determine the role of miR-939 in PCa cell proliferation and apoptosis in vitro, whereas a tumor xenograft model was generated to evaluate the effect of miR-939 on tumor growth in vivo. Transwell assays were performed to investigate whether miR-939 affects the migration and invasiveness of PCa cells. Results: miR-939 was found to be downregulated in PCa tissues and cell lines, and this downregulation was significantly correlated with tumor stage and lymphatic metastasis. Patients with PCa exhibiting low miR-939 expression had shorter overall survival than those exhibiting high miR-939 expression. Exogenous miR-939 expression suppressed PCa cell proliferation, colony formation, migration, and invasion in vitro; enhanced apoptosis in vitro; and decreased tumor growth in vivo. Investigation of the underlying molecular mechanisms revealed hepatoma-derived growth factor (HDGF) as a direct target gene of miR-939 in PCa. HDGF was found to be significantly upregulated in PCa tissues, and its expression was inversely correlated with miR-939 expression. HDGF silencing and miR-939 upregulation showed similar effects in PCa. Restored HDGF expression counteracted the tumor-suppressive activity of miR-939 overexpression in PCa cells. Furthermore, ectopic miR-939 expression inhibited the WNT/β-catenin pathway activation in PCa both in vitro and in vivo by downregulating HDGF. Conclusion: miR-939 functions as a tumor suppressor during PCa tumorigenesis by directly targeting HDGF and deactivating the WNT/β-catenin pathway, suggesting the miR-939/ HDGF/WNT/β-catenin pathway as an effective target for PCa therapy.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-939 Directly Targets HDGF to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway

Song¹,

Zhang²,

Zi³

et al. 2020

OTT

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“…MiR-125b is involved in regulating NF-κB, p53, PI3K/AKT/mTORC1, ERBB2, WNT, and other signaling pathways, thereby controlling cell proliferation, differentiation, metabolism, apoptosis, drug resistance, and tumor immunity. MiR-21 is another oncogenic miR overexpressed in PCa that inhibits various tumor suppressor genes such as PTEN enhancing mTORC1 activation [ 334 , 335 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 ].…”

Section: Milk-induced Overactivation Of Mtorc1 and Diseases Of CIVmentioning

confidence: 99%

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

Melnik

2021

Biomolecules

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The consumption of cow’s milk is a part of the basic nutritional habits of Western industrialized countries. Recent epidemiological studies associate the intake of cow’s milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. This review presents current epidemiological and translational evidence linking milk consumption to the regulation of mTORC1, the master-switch for eukaryotic cell growth. Epidemiological studies confirm a correlation between cow’s milk consumption and birthweight, body mass index, onset of menarche, linear growth during childhood, acne vulgaris, type 2 diabetes mellitus, prostate cancer, breast cancer, hepatocellular carcinoma, diffuse large B-cell lymphoma, neurodegenerative diseases, and all-cause mortality. Thus, long-term persistent consumption of cow’s milk increases the risk of mTORC1-driven diseases of civilization. Milk is a highly conserved, lactation genome-controlled signaling system that functions as a maternal-neonatal relay for optimized species-specific activation of mTORC1, the nexus for regulation of eukaryotic cell growth, and control of autophagy. A deeper understanding of milk´s impact on mTORC1 signaling is of critical importance for the prevention of common diseases of civilization.

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“…Previous studies indicated that these miRNAs could modulate cancer microenvironment or tumor transformation. miR-21 overexpression promoted tumorigenesis in prostate [ 28 ] and cervical [ 29 ] cancers. Also, miR-21 upregulation increased chemoresistance in lung adenocarcinoma [ 30 ], invasiveness and angiogenesis in renal carcinoma [ 31 ] and lymphoma [ 32 ].…”

Section: Main Bodymentioning

confidence: 99%

Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation

et al. 2021

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Background microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell communication, and anti-cancer immunity. Main Body Anesthetics can affect cell biology through miRNA-mediated regulation of messenger RNA (mRNA). Indeed, sevoflurane was reported to upregulate miR-203 and suppresses breast cancer cell proliferation. Propofol reduces matrix metalloproteinase expression through its impact on miRNAs, leading to anti-cancer microenvironmental changes. Propofol also modifies miRNA expression profile in circulating extracellular vesicles with their subsequent anti-cancer effects via modulating cell-to-cell communication. Conclusion Inhalational and intravenous anesthetics can alter cancer cell biology through various cellular signaling pathways induced by miRNAs’ modification. However, this area of research is insufficient and further study is needed to figure out optimal anesthesia regimens for cancer patients.

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Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5

Cited by 34 publications

References 54 publications

<p>MicroRNA-939 Directly Targets <em>HDGF</em> to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway</p>

<p>MicroRNA-939 Directly Targets <em>HDGF</em> to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway</p>

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation

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